Iron Oxide Nanoparticles: An Alternative for Positive Contrast in Magnetic Resonance Imaging

Fernández‐Barahona, Irene; Muñoz-Hernando, María; Ruíz-Cabello, Jesús; Herranz, Fernando; Pellico, Juan

doi:10.3390/inorganics8040028

Cited by 60 publications

(50 citation statements)

References 118 publications

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“…MRI is a diagnostic technique widely employed due to its ability to distinguish between healthy and pathological tissues. Manganese ferrites are good T 2 contrast agents of MRI though, at exceedingly small nanoparticle size, MnFe 2 O 4 nanoparticles exhibit good positive blood pool contrast [ 81 , 82 ]. As a T 2 contrast agent, the parameter which determines the quality of contrast is known as relaxivity ( r 2 ).…”

Section: Resultsmentioning

confidence: 99%

Manganese Ferrite Nanoparticles (MnFe2O4): Size Dependence for Hyperthermia and Negative/Positive Contrast Enhancement in MRI

et al. 2020

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We synthesized manganese ferrite (MnFe2O4) nanoparticles of different sizes by varying pH during chemical co-precipitation procedure and modified their surfaces with polysaccharide chitosan (CS) to investigate characteristics of hyperthermia and magnetic resonance imaging (MRI). Structural features were analyzed by X-ray diffraction (XRD), high-resolution transmission electron microscopy (TEM), selected area diffraction (SAED) patterns, and Mössbauer spectroscopy to confirm the formation of superparamagnetic MnFe2O4 nanoparticles with a size range of 5–15 nm for pH of 9–12. The hydrodynamic sizes of nanoparticles were less than 250 nm with a polydispersity index of 0.3, whereas the zeta potentials were higher than 30 mV to ensure electrostatic repulsion for stable colloidal suspension. MRI properties at 7T demonstrated that transverse relaxation (T2) doubled as the size of CS-coated MnFe2O4 nanoparticles tripled in vitro. However, longitudinal relaxation (T1) was strongest for the smallest CS-coated MnFe2O4 nanoparticles, as revealed by in vivo positive contrast MRI angiography. Cytotoxicity assay on HeLa cells showed CS-coated MnFe2O4 nanoparticles is viable regardless of ambient pH, whereas hyperthermia studies revealed that both the maximum temperature and specific loss power obtained by alternating magnetic field exposure depended on nanoparticle size and concentration. Overall, these results reveal the exciting potential of CS-coated MnFe2O4 nanoparticles in MRI and hyperthermia studies for biomedical research.

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Section: Resultsmentioning

confidence: 99%

Manganese Ferrite Nanoparticles (MnFe2O4): Size Dependence for Hyperthermia and Negative/Positive Contrast Enhancement in MRI

et al. 2020

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“…Generally, large SPIONs provide T 2 contrast due to the magnetic inhomogeneity induced by their strong magnetic moment. However, SPIONs-based T 2 contrast agents generate dark signal in T 2 -weighted MRI that can mislead the clinical diagnosis (Zhao et al, 2013;Fernández-Barahona et al, 2020). In this respect, T 1 contrast agents are more desirable for high accurate resolution imaging (Wei et al, 2017;Li et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Surface Coating of Iron Oxide Nanoparticles on Magnetic Resonance Imaging Relaxivity

Ahmadpoor

Masood

Feliu

et al. 2021

Front. Nanotechnol.

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Iron oxide nanoparticles (IONPs) with acceptable biocompatibility and size-dependent magnetic properties can be used as efficient contrast agents in magnetic resonance imaging (MRI). Herein, we have investigated the impact of particle size and surface coating on the proton relaxivity of IONPs, as well as engineering of small IONPs' surface coating as a strategy for achieving gadolinium-free contrast agents. Accordingly, polymer coating using poly(isobutylene-alt-maleic anhydride) (PMA) with overcoating of the original ligands was applied for providing colloidal stability to originally oleic acid–capped IONPs in aqueous solution. In case of replacement of the original ligand shell, the polymer had been modified with dopamine. Furthermore, the colloidal stability of the polymer-coated IONPs was evaluated in NaCl and bovine serum albumin (BSA) solutions. The results indicate that the polymer-coated IONPs which involved replacement of the original ligands exhibited considerably better colloidal stability and higher proton relaxivity in comparison to polymer-coated IONPs with maintained ligand shell. The highest r2/r1 we obtained was around 300.

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“…Table 6 points out just a few examples of nanomaterial tracers that have been assessed in numerous preclinical studies, ranging from breast and cardiac to brain monitoring. Notably, biocompatible iron oxide-based nanoparticles that have been approved by the FDA for clinical use as MRI contrast agents (as presented in Table 7 ) are still paving the road toward achievement of the critical requirements for use in practical applications [ 270 ]. Their chemical stability, dispersion in biological media, uniformity in size and diverse coatings continue to make them the subject of numerous articles and studies in ongoing efforts to develop new candidates.…”

Section: Imaging Pre-clinical and Clinical Studies Of Core-shell Iron Oxide Agentsmentioning

confidence: 99%

Imaging Constructs: The Rise of Iron Oxide Nanoparticles

et al. 2021

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Over the last decade, an important challenge in nanomedicine imaging has been the work to design multifunctional agents that can be detected by single and/or multimodal techniques. Among the broad spectrum of nanoscale materials being investigated for imaging use, iron oxide nanoparticles have gained significant attention due to their intrinsic magnetic properties, low toxicity, large magnetic moments, superparamagnetic behaviour and large surface area—the latter being a particular advantage in its conjunction with specific moieties, dye molecules, and imaging probes. Tracers-based nanoparticles are promising candidates, since they combine synergistic advantages for non-invasive, highly sensitive, high-resolution, and quantitative imaging on different modalities. This study represents an overview of current advancements in magnetic materials with clinical potential that will hopefully provide an effective system for diagnosis in the near future. Further exploration is still needed to reveal their potential as promising candidates from simple functionalization of metal oxide nanomaterials up to medical imaging.

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Iron Oxide Nanoparticles: An Alternative for Positive Contrast in Magnetic Resonance Imaging

Cited by 60 publications

References 118 publications

Manganese Ferrite Nanoparticles (MnFe2O4): Size Dependence for Hyperthermia and Negative/Positive Contrast Enhancement in MRI

Manganese Ferrite Nanoparticles (MnFe2O4): Size Dependence for Hyperthermia and Negative/Positive Contrast Enhancement in MRI

The Effect of Surface Coating of Iron Oxide Nanoparticles on Magnetic Resonance Imaging Relaxivity

Imaging Constructs: The Rise of Iron Oxide Nanoparticles

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