T1 mapping for detection of left ventricular myocardial fibrosis in hypertrophic cardiomyopathy: A preliminary study

Lu, Minjie; Zhao, Shihua; Yin, Gang; Jiang, Shiliang; Zhao, Tianming; Chen, Xiuyu; Tian, Lu; Zhang, Yan; Wei, Yun-qing; Liu, Qiong; He, Zhaoyi; Xue, Hui; An, Jing; Shah, Saurabh

doi:10.1016/j.ejrad.2012.12.014

Cited by 33 publications

(22 citation statements)

References 30 publications

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“…Analyses of the T 1 relaxation maps were performed directly on the maps as described in a previous study . Briefly, after generating the T 1 maps, short‐axis images were automatically contoured to outline the endocardium and epicardium.…”

Section: Methodsmentioning

confidence: 99%

Effects of short‐term levothyroxine therapy on myocardial injuries in patients with severe overt hypothyroidism: Evidence from a cardiac MRI Study

Gao

Chen

Liu

et al. 2017

Magnetic Resonance Imaging

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Section: Methodsmentioning

confidence: 99%

Effects of short‐term levothyroxine therapy on myocardial injuries in patients with severe overt hypothyroidism: Evidence from a cardiac MRI Study

Gao

Chen

Liu

et al. 2017

Magnetic Resonance Imaging

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“…In HCM, LGE is a risk factor for heart failure and an additional risk factor for SCD [90]. T 1 mapping can have additive value [91]. Native T 1 is modestly elevated in HCM as compared to healthy controls and highest in the areas of maximal hypertrophy [90].…”

Section: T1 Mapping and Ecv In Selected Modest Signal Diseasesmentioning

confidence: 99%

T1 mapping in cardiac MRI

et al. 2017

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Quantitative myocardial and blood T1 have recently achieved clinical utility in numerous pathologies, as they provide non-invasive tissue characterization with the potential to replace invasive biopsy. Native T1 time (no contrast agent), changes with myocardial extracellular water (edema, focal or diffuse fibrosis), fat, iron, and amyloid protein content. After contrast, the extracellular volume fraction (ECV) estimates the size of the extracellular space and identifies interstitial disease. Spatially resolved quantification of these biomarkers (so-called T1 mapping and ECV mapping) are steadily becoming diagnostic and prognostically useful tests for several heart muscle diseases, influencing clinical decision-making with a pending second consensus statement due mid-2017. This review outlines the physics involved in estimating T1 times and summarizes the disease-specific clinical and research impacts of T1 and ECV to date. We conclude by highlighting some of the remaining challenges such as their community-wide delivery, quality control, and standardization for clinical practice.

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“…HCM is the most common monogenic cardiac disorder and is a common cause of sudden death in the young population [35]. Varying degrees of myocardial fibrosis are present in HCM [36] and the occurrence of myocardial fibrosis correlates with wall thickness, wall motion abnormalities [37] and ventricular tachycardia [38]. Focal fibrotic infiltrations can be detected via LGE imaging and LGE might also be useful as a biomarker for risk stratification and therapeutic monitoring [39 -42].…”

Section: Hypertrophic Cardiomyopathy (Hcm)mentioning

confidence: 99%

T1, T2 Mapping and Extracellular Volume Fraction (ECV): Application, Value and Further Perspectives in Myocardial Inflammation and Cardiomyopathies

Roller¹,

Harth²,

Schneider³

et al. 2015

Fortschr Röntgenstr

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!Cardiac magnetic resonance imaging (CMRI) is a versatile diagnostic tool. One of its main advantages is the possibility of tissue characterization. T1-weighted images for scar and T2-weighted images for edema visualization are key methods for tissue characterization. Otherwise these sequences are strongly limited for the detection of diffuse myocardial pathologies. Recently, rapid technical innovations have generated new techniques. T1, T2 mapping and evaluation of the extracellular volume fraction (ECV) allow quantification of diffuse myocardial pathologies and showed great potential in the visualization of fibrosis, edema, amyloid, iron overload and lipid. In the future these techniques might enable the detection of early cardiac involvement, even act as a prognosticator. Moreover, therapy monitoring and follow-up might be possible due to versatile parameter quantification with these new techniques. Key points:▶ CMR allows for tissue characterization via T1-and T2-weighted sequences.▶ In cases of diffuse, global myocardial pathologies, correct image interpretation with traditional CMR sequences might be difficult.▶ T1, T2 mapping and ECV can quantify diffuse, global myocardial pathologies.

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T1 mapping for detection of left ventricular myocardial fibrosis in hypertrophic cardiomyopathy: A preliminary study

Cited by 33 publications

References 30 publications

Effects of short‐term levothyroxine therapy on myocardial injuries in patients with severe overt hypothyroidism: Evidence from a cardiac MRI Study

Effects of short‐term levothyroxine therapy on myocardial injuries in patients with severe overt hypothyroidism: Evidence from a cardiac MRI Study

T1 mapping in cardiac MRI

T1, T2 Mapping and Extracellular Volume Fraction (ECV): Application, Value and Further Perspectives in Myocardial Inflammation and Cardiomyopathies

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