T-S Fuzzy-Based Optimal Control for Minimally Invasive Robotic Surgery with Input Saturation

Wang, Faguang; Wang, Hongmei; Zhang, Yong; Guo, Xianping

doi:10.1155/2018/5738274

Cited by 3 publications

(2 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The differentiation of stem cells is influenced by both internal and external factors. [46][47][48] Methods to promote the stem cell osteogenesis to efficiently build tissue-engineered bone have become a topic of intense research. [49,50] Our study demonstrates the potential of apoVs in bone tissue engineering.…”

Section: Hbmmsc-derived Apovs Promote Msc Osteogenesismentioning

confidence: 99%

Apoptotic Vesicles Regulate Bone Metabolism via the miR1324/SNX14/SMAD1/5 Signaling Axis

Zhu

Yang

Cheng

et al. 2023

Small

View full text Add to dashboard Cite

Mesenchymal stem cells (MSCs) are easily isolated from tissues and have the ability to self-proliferate and to differentiate along different cell lineages, such that they are commonly used in tissue regeneration. [10][11][12][13][14] Several clinical studies have shown that MSCs are safe and effective when used in tissue repair and wound healing. [15][16][17][18][19][20][21] However, despite the therapeutic efficacy of MSCs, there are significant costs and challenges associated with their therapeutic use, because they require strict monitoring of manufacturing, processing, and storage to ensure optimal viability and potency following transplantation. [22,23] Some studies have shown that stem cells transplanted into the body initially undergo significant apoptosis [24][25][26][27][28][29] and that the direct transplantation of apoptotic stem cells can have lasting effects. [30] Apoptosis plays an important role in maintaining physiological homeostasis. [31][32][33] Apoptotic vesicles (apoVs) are extracellular vesicles rich in proteins, RNA, and lipids that are released during apoptosis. [34] Their role is to mediate the transfer of substances and signal exchange between cells and thus maintain homeostasis. In a previous study, we examined the characteristics and specific markers of MSC-derived apoVs and found that proteins on the surface of apoVs regulated platelet aggregation. [35] In another study, we demonstrated the therapeutic effect of MSC-derived apoVs, including in type 2 diabetes, through their interactions with hepatic macrophages. [36] We also found that apoVs activate the Fas pathway in multiple myeloma cells and thus induce apoptosis in these tumor cells. [37] Pluripotent stem cell (PSC)-derived apoVs (PSC-apoVs) can inherit pluripotent molecules from PSCs to stimulate adult stem cells and promote wound healing in mouse skin. [38] Exogenous apoVs (apoEVs) have been reported to promote wound healing and hair growth by activating the Wnt/β-catenin pathway. [39] The administration of apoVs can prevent Th17 differentiation and memory T cell formation to ameliorate inflammation and joint erosion in a mouse model of arthritis. [40] While mouse MSC-derived apoVs has been used to treat osteoporosis, [41] whether apoVs derived from human bone marrow mesenchymal stem cells (hBMMSCs) can impact bone metabolism is unknown. Thus, we investigated the regulatory role of apoVs in bone metabolism and therapeutic effects on bone defects and bone loss. Our results provide an important theoretical basis for novel clinical applications of hBMMSCs-derived apoVs. Mesenchymal stem cells (MSCs) are widely used in the treatment of diseases. After their in vivo application, MSCs undergo apoptosis and release apoptotic vesicles (apoVs). This study investigates the role of apoVs derived from human bone marrow mesenchymal stem cells (hBMMSCs) in bone metabolism and the molecular mechanism of the observed effects. The results show that apoVs can promote osteogenesis and inhibit osteoclast formation in vitro and in vivo. ApoVs may t...

show abstract

Section: Hbmmsc-derived Apovs Promote Msc Osteogenesismentioning

confidence: 99%

Apoptotic Vesicles Regulate Bone Metabolism via the miR1324/SNX14/SMAD1/5 Signaling Axis

Zhu

Yang

Cheng

et al. 2023

Small

View full text Add to dashboard Cite

show abstract

“…The use of these substitutes can avoid the adverse effects associated with the use of autografts and allografts, such as immune rejection, limited number of donors, and secondary injury of donor. [3] More importantly, the addition of bioactive molecules, such as drugs [4] and BMPs, [5] can enhance the bone repair function of bone replacement materials. This may be associated with the promotion of osteogenic differentiation of BMSCs.…”

Section: Introductionmentioning

confidence: 99%

Strontium‐Doped Hydroxyapatite Promotes Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells in Osteoporotic Rats through the CaSR‐JAK2/STAT3 Signaling Pathway

Ren

Xin

Yang

et al. 2022

Advanced NanoBiomed Research

View full text Add to dashboard Cite

Self‐repair of critical bone defects from periodontitis, tumor resection, and trauma is difficult. Osteoporosis is an abnormal bone metabolism disease characterized by increased bone resorption, decreased bone formation, and decreased activity of bone marrow mesenchymal stem cells (BMSCs), which further inhibits the repair of bone defects. Improving the osteogenic ability of BMSCs after osteoporosis is an important step in treating osteoporotic bone defects. Hydroxyapatite (HA) with good biocompatibility is widely used in bone material research. HA and strontium‐doped hydroxyapatite (Sr‐HA) microspheres are synthesized following a hydrothermal method, and the characteristics and the ability of these microspheres are explored to promote osteogenesis. Further, the role of the calcium‐sensing receptor (CaSR) and Janus kinase 2 gene/signal transducers and activators of transcription 3 (JAK2/STAT3) signaling pathway in this process are investigated. The results show that Sr‐HA, rather than HA alone, significantly promote the osteogenic differentiation of BMSCs in vitro and bone formation in vivo. Further, the effect of promoting osteogenic differentiation is realized by activating the CaSR‐JAK2/STAT3 signaling pathway. Therefore, the study demonstrates that Sr‐HA is the better choice for restoring critical bone defects.

show abstract

Descriptor Representation-Based Guaranteed Cost Control Design Methodology for Polynomial Fuzzy Systems

Shen

Chen

et al. 2022

Processes

View full text Add to dashboard Cite

This paper presents a descriptor representation-based guaranteed cost design methodology for polynomial fuzzy systems. This methodology applies the descriptor representation for presenting the closed-loop system of the polynomial fuzzy model with a parallel distributed compensation (PDC) based fuzzy controller. By the utility of descriptor representation, the guaranteed cost control (GCC) design analysis can utilize polynomial fuzzy slack matrices for obtaining less conservative results. The proposed GCC design is presented as the sum-of-squares (SOS) conditions. The application of polynomial fuzzy slack matrices leads to the double fuzzy summation issue in the control design. Accordingly, the copositive relaxation works out the problem well and is adopted in the control design analysis. The GCC design minimizes the upper limit of a predesignated cost function. According to the performance function, two simulation examples are provided to demonstrate the validity of the proposed GCC design. In these two examples, the proposed design obtains superior results.

show abstract

T-S Fuzzy-Based Optimal Control for Minimally Invasive Robotic Surgery with Input Saturation

Cited by 3 publications

References 25 publications

Apoptotic Vesicles Regulate Bone Metabolism via the miR1324/SNX14/SMAD1/5 Signaling Axis

Apoptotic Vesicles Regulate Bone Metabolism via the miR1324/SNX14/SMAD1/5 Signaling Axis

Strontium‐Doped Hydroxyapatite Promotes Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells in Osteoporotic Rats through the CaSR‐JAK2/STAT3 Signaling Pathway

Descriptor Representation-Based Guaranteed Cost Control Design Methodology for Polynomial Fuzzy Systems

Contact Info

Product

Resources

About