T-Lymphoma Associated With HTLV-I Outside the Caribbean and Japan

Tubiana, N.; Lecaer, F.; Horchowski, N.; Sébahoun, G; Lejeune, Catherine; Sainty, D; Bagarry, D.; Carcassonne, Y; Cunningham, David; Gilchrist, NigelL.; Jack, Andrew; Dalgleish, AngusG.; Soukop, M.; Lee, F.D.; Baas, J.; Thomas, L.; Oostveen, J. W. Van; Daenen, Simon; Slater, Rosalyn

doi:10.1016/s0140-6736(85)90391-5

Cited by 10 publications

(1 citation statement)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The overall risk is 2.5% in a carrier that lives to age 70 years [8]. In the Caribbean islands, 3% to 6% of the population is seropositive for HTLV-I, whereas less than 1% of people in low-risk areas of the United States and Europe are infected [9][10][11][12]. Seroprevalence increases with age and is more common in females.…”

Section: Introductionmentioning

confidence: 99%

Human T-cell lymphotropic-I-associated leukemia/lymphoma

Siegel

Gartenhaus

Kuzel

2001

Curr. Treat. Options in Oncol.

View full text Add to dashboard Cite

Human T-cell lymphotropic virus-I (HTLV-I)-related adult T-cell leukemia/lymphoma (ATL) is a model disease for proof of viral oncogenesis. HTLV-I infection is endemic in southern Japan and the Caribbean basin, and occurs sporadically in Africa, Central and South America, the Middle East, and the southeastern United States. ATL occurs in only 2% to 4% of HTLV-I-infected people [1-3]. When it does occur, it is usually aggressive and difficult to treat; most people survive for less than 1 year [1-3]. Combination chemotherapy with cytotoxic agents has yielded complete response rates of 20% to 45%, but responses usually last only a few months [3]. Recently, novel treatments, such as monoclonal antibodies directed at the interleukin-2 receptor and the combination of interferon alfa and zidovudine, have been shown to be active in the treatment of patients with ATL. A small percentage of patients achieve long-lasting remissions [2,3].

show abstract

Section: Introductionmentioning

confidence: 99%

Human T-cell lymphotropic-I-associated leukemia/lymphoma

Siegel

Gartenhaus

Kuzel

2001

Curr. Treat. Options in Oncol.

View full text Add to dashboard Cite

show abstract

Chronic Myelopathies Associated With Human T-Lymphotropic Virus Type I

Gout

Gessain²,

Bolgert³

et al. 1989

Arch Neurol

View full text Add to dashboard Cite

The cutaneous form of adult t-cell leukemia/lymphoma in a woman from the ivory coast. Clinical, immunovirologic studies and a review of the African adult T-cell leukemia/lymphoma cases

Gessain

Caumes

Feyeux

et al. 1992

Cancer

View full text Add to dashboard Cite

A 36‐year‐old woman from Ivory Coast, who has lived in France since 1976, had multiple cutaneous nodules and tumors in 1988. Histopathologic studies showed a massive infiltration of the dermis and hypodermis by a diffuse proliferation of mature activated T‐cells (CD4‐posi‐tive, CD25‐positive, HLA‐DR‐positive) with irregular nuclei. The patient did not present with a leukemic picture and only few lymphoid cells with abnormally shaped nuclei were present in the blood. Human T leukemia/lymphoma virus type I (HTLV‐I) antibodies were present in the serum and specific HTLV‐I pol sequences were detected in the DNA extracted from the tumor nodules and peripheral blood mononuclear cells (PBMC) using the polymerase chain reaction technique. Whereas only a polyclonal integration of HTLV‐I provirus was detectable in the PBMC, a clonal integration of three HTLV‐I proviruses was demonstrated in the tumor nodules DNA, establishing with certainty the diagnosis of HTLV‐I‐in‐duced adult T‐cell leukemia/lymphoma (ATL). This case illustrates the need for molecular studies to differentiate without ambiguity an ATL from any other type of cutaneous lymphoproliferation, even when it occurs in a HTLV‐I‐seropositive individual. The situation of HTLV‐I‐asso‐ciated ATL in Africa is reviewed. Cancer 1992; 69:1362‐1367.

show abstract

T-Lymphoma Associated With HTLV-I Outside the Caribbean and Japan

Cited by 10 publications

References 8 publications

Human T-cell lymphotropic-I-associated leukemia/lymphoma

Human T-cell lymphotropic-I-associated leukemia/lymphoma

Chronic Myelopathies Associated With Human T-Lymphotropic Virus Type I

The cutaneous form of adult t-cell leukemia/lymphoma in a woman from the ivory coast. Clinical, immunovirologic studies and a review of the African adult T-cell leukemia/lymphoma cases

Contact Info

Product

Resources

About