1996
DOI: 10.1177/10454411960070010501
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T-Lymphocyte Interactions With Endothelium and Extracellular Matrix

Abstract: T-lymphocyte movement out of the bloodstream and into tissue is critical to the success of these cells in their role in immunosurveillance. This process involves interactions of the T-cell with endothelium as well as with extracellular matrix. Central to these interactions are a number of T-cell adhesion molecules and their endothelial and extracellular matrix ligands. The identification and functional characterization of adhesion molecules have been the subject of intensive research in recent years. We highli… Show more

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Cited by 18 publications
(17 citation statements)
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“…In addition, this study undertook an immunohistochemical analysis of adhesion molecule expression by endothelial cells of the conjunctival vasculature, looking particularly for evidence of adhesion molecules found on HEVs at other sites in the body namely Vascular Adhesion Protein-1 (VAP-1) found in lymph node HEVs (Salmi, Kalimo and Jalkanen, 1993) and Mucosal Addressin Cell Adhesion Molecule-1 (MadCAM-1) found in Peyer's patches and gut lamina propria HEVs (Hunt et al, 1996).…”
Section: Introductionmentioning
confidence: 99%
“…In addition, this study undertook an immunohistochemical analysis of adhesion molecule expression by endothelial cells of the conjunctival vasculature, looking particularly for evidence of adhesion molecules found on HEVs at other sites in the body namely Vascular Adhesion Protein-1 (VAP-1) found in lymph node HEVs (Salmi, Kalimo and Jalkanen, 1993) and Mucosal Addressin Cell Adhesion Molecule-1 (MadCAM-1) found in Peyer's patches and gut lamina propria HEVs (Hunt et al, 1996).…”
Section: Introductionmentioning
confidence: 99%
“…1 Overexpression and altered glycosylation of mucins on cancer cells, compared with normal cells, makes them ideal candidates for tumor-based vaccines. 2,3 CD43 is one such member of the mucin family, 4 and is widely expressed on the surface of hematopoietic cells.…”
Section: Introductionmentioning
confidence: 99%
“…The composition of extracellular matrix differs between tissues and constitutes an organ-specific microenvironment with the ability to recruit and retain specific cell types (Hunt et al, 1996). Pathological conditions, including inflammation and cancer are associated with changes in the composition of extracellular matrix (Rojkind, 1988), and thus changes in the potential to recruit or retain inflammatory cells.…”
mentioning
confidence: 99%