T-Helper Cell Type 17/Regulatory T-Cell Immunoregulatory Balance in Human Radicular Cysts and Periapical Granulomas

Marçal, Juliana R.B.; Samuel, Renata Oliveira; Fernandes, Danielle; Araújo, Marcelo Sivieri de; Napimoga, Marcelo Henrique; Pereira, Sanívia Aparecida Lima; Clemente-Napimoga, Juliana Trindade; Alves, Polyanna Miranda; Mattar, Rinaldo; Rodrigues, Virmondés; Rodrigues, Denise Bertulucci Rocha

doi:10.1016/j.joen.2010.03.020

Cited by 95 publications

(123 citation statements)

References 28 publications

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“…In phase 2, the full-text of 18 studies were retrieved and evaluated. Of those, only eight 14,15,16,17,18,19,20,21 met the eligibility criteria. No additional study was identified in the reference lists of the included articles and in the grey literature.…”

Section: Study Selectionmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

“…14,15,18,21 All studies involved human periapical lesion fragments. Samples of six articles 14,15,18,19,20,21 were obtained directly through surgery and samples of the other two studies were obtained through institutional archives collected from previous surgical procedures. 16,17 Fou r a r t icles repor ted t he mea n age of participants 18,19,20,21 and five studies defined the range between 17 and 64 years.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Samples of six articles 14,15,18,19,20,21 were obtained directly through surgery and samples of the other two studies were obtained through institutional archives collected from previous surgical procedures. 16,17 Fou r a r t icles repor ted t he mea n age of participants 18,19,20,21 and five studies defined the range between 17 and 64 years. 14,15,19,20,21 The language of the articles was predominantly English, although the studies were conducted in different countries (Brazil, United States and Serbia).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…The analytical method used in two studies was the ELISA method. 18,20 Real-time polymerase chain reaction (RT-PCR) was used in three studies, 14,15,21 flow cytometry in two studies, 19,20 confocal microscopy in one study, 19 and immunohistochemistry was used in four studies. 16,17,18,20 The entire description of studies characteristics is shown in Table 2.…”

Section: Study Characteristicsmentioning

confidence: 99%

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Treg and Th17 cells in inflammatory periapical disease: a systematic review

et al. 2017

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The process involved in periapical lesions, which occur as an outcome of pulpal necrosis, is regulated by the immune system including regulatory T cells (Treg) and T helper 17 cell (Th17) responses. The objective of this study was to conduct a frequency systematic review to determine the presence of Treg/Th17 responses and the influence of these cells in the progression of chronic inflammatory periapical lesions in humans. A systematic computerized search was carried out in Pubmed, Medline, Web of Science and Scopus electronic databases from their date of inception through the first week of May 2017. In addition, the reference lists of the included articles and the grey literature were hand-searched. Articles that evaluated the presence and influence of Treg/Th17 in the progression of human periapical lesions were included. Study selection and the quality assessment of the included articles (using the Newcastle-Ottawa scale) were carried out by two authors. Fifty-seven titles/abstracts were screened and eight studies met the eligibility criteria and were included in this systematic review. The included studies showed large variation in the type of periapical lesion assessed, mean age, age range, type of experiment and findings regarding the participation of Th17 and Treg in the status of inflammatory periapical lesions. The studies showed the involvement of Treg in the modulation of the inflammatory response in radicular cysts and periapical granulomas. This systematic review highlights the relationship between Treg and Th17 acting in a subtle balance inhibiting or promoting the progression of human periapical lesions.

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