T cell subsets and Langerhans cells in skin tumours

Fernández-Bussy, Ramón; Cambazard, F.; Mauduit, G; Schmitt, Daniel; Thivolet, J

doi:10.1016/0277-5379(83)90056-1

Cited by 35 publications

(9 citation statements)

References 9 publications

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“…Increased numbers of Langerhans' cells (44,45) can be identified at the infiltrative margins of squamous neoplasms and are suspected to be "related to the invasive process which is localized to focal areas at the periphery of infiltrating tumors" (46). The highest density of OSM-labeled macrophages in this study was observed at the infiltrating margins of both KAs and SCCs.…”

Section: Discussionmentioning

confidence: 51%

Comparison of Oncostatin M Expression in Keratoacanthoma and Squamous Cell Carcinoma

et al. 2000

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Oncostatin M (OSM) is a 28-kDa glycoprotein, produced by stimulated macrophages and T lymphocytes, that inhibits the proliferation and induces differentiation of a number of different cell lines derived from solid tumors. To determine whether keratoacanthoma (KA) is unique or a variant of squamous cell carcinoma (SCC), we compared the immunohistochemical expression of OSM in the tumor cells and peri-and intratumoral macrophages of 21 mature KAs, 7 regressing KAs, and 27 SCCs. An inverse correlation was identified between OSM tumor labeling and the density of OSM-labeled tumor-associated macrophages for KAs (r ‫؍‬ ؊.4; P ‫؍‬ .09). OSM tumor expression was significantly more frequent and more intense in KAs than in SCCs (95% versus 63%; P < .01). In contrast, the density of OSM-labeled macrophages was significantly higher in SCCs compared with mature KAs (7/3 high power fields versus 4/3 high power fields; P ‫؍‬ .02). These OSM-positive macrophages were predominantly located at the advancing, infiltrative margins of both neoplasms. Regressing KAs demonstrated a decreased level of OSM tumor expression compared with mature KAs (53% versus 95%; P ‫؍‬ .001), but there was no difference in density of OSMlabeled macrophages. Both the above differences and the overlapping patterns of OSM expression suggest that KAs are a variant of SCC where OSM, possibly as an autocrine factor, may mediate KA's overwhelming but not absolute tendency to involute.

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Section: Discussionmentioning

confidence: 51%

Comparison of Oncostatin M Expression in Keratoacanthoma and Squamous Cell Carcinoma

et al. 2000

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“…This leads to the generation of tumor specific effector T-cells capable of recognizing and eliminating tumor cells. [78] Several researchers have investigated the distribution of LCs in squamous cell carcinoma, however, none have yielded consistent results, some observed an increase[1279] while few observed a decrease[8081] in LC density, whereas some observed no change at all. [82]…”

Section: Langerhans Cells In Oral Diseasesmentioning

confidence: 99%

Langerhans cells and their role in oral mucosal diseases

Upadhyay

Agrawal

et al. 2013

North Am J Med Sci

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Dendritic cells are arguably the most potent antigen-presenting cells and may be the only cells capable of initiating the adaptive immune response. The epithelial residents of dendritic cells are Langerhans cells, which serve as the “sentinels” of the mucosa, altering the immune system not only to pathogen entry but also of tolerance to self antigen and commensal microbes. Oral mucosal Langerhans cells are capable of engaging and internalizing a wide variety of pathogens and have been found responsive to nickel in patients with nickel allergies, oral Candida species, oral lichen planus, lichenoid drug eruptions, graft versus host diseases, periodontal diseases median rhomboid glossitis, human immunodeficiency virus infection, hairy leukoplakia of the tongue, and oral squamous cell carcinoma. Review focuses on the role of antigen-presenting cells in particular Langerhans cells to better understand the mechanisms underlying immune responses. In this review, comprehensive detail about mucosal diseases has been compiled using the PubMed database and through textbooks.

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“…2 Basal cell carcinoma (BCC) belongs to non-melanoma skin cancer, the most common one, and mainly develops in the sunexposed face skin. [4][5][6] We evaluated LCs in BCC in the sun-exposed skin. [4][5][6] We evaluated LCs in BCC in the sun-exposed skin.…”

Section: Decreased Number Of Langerhans Cells In Basal Cell Carcinomamentioning

confidence: 99%