Decreased number of Langerhans cells in basal cell carcinoma

Rotsztejn, Helena; Jesionek-Kupnicka, Dorota; Trznadel-Budźko, Ewa

doi:10.1111/j.1468-3083.2008.02913.x

Cited by 5 publications

(7 citation statements)

References 8 publications

(15 reference statements)

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“…CD1a expressing dendritic cells were scarce in peritumoral infiltrates in all tumor groups. Previous studies reported Langerhans cells to be depleted in BCC samples 22‐24 . Dendritic cell density in primary tumors of the recurrent patient group was lower than that of non‐recurrent tumors in our study.…”

Section: Discussioncontrasting

confidence: 63%

Sparsity of dendritic cells and cytotoxic T cells in tumor microenvironment may lead to recurrence in basal cell carcinoma

et al. 2020

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Background Antitumor immune response affects tumor growth. The effect of antitumor immune response on recurrence has been poorly studied in basal cell carcinoma (BCC). Objectives To investigate the effects of the peritumoral immune infiltrate on BCC recurrence. Methods A total of 30 BCC patients without recurrence and 29 BCC patients with recurrence were included in this retrospective study. Non-recurrent tumor samples as well as primary and recurrent tumor samples from the recurrent group were stained immunohistochemically with anti-CD4, CD8, CD25, FOXP3, CD68, CD163, and CD1a antibodies. Immune infiltrates were semiquantitatively evaluated. Results BCC tumor microenvironment was rich in CD4+ cells. CD163 expression was higher than CD68. In primary tumors of the recurrent group, CD8 expression was significantly lower than CD4 expression. CD1a expression was lower in primary tumors of the recurrent group than in nonrecurrent tumors. Conclusions Our results suggest the existence of an immunosuppressive microenvironment in BCC. Lower CD8+ T-cell numbers and sparsity of dendritic cells in primary tumors of recurrent patients suggest further immunosuppression in the tumor microenvironment and an increase in recurrence risk. This is the first study that evaluates and compares tumor immune microenvironments of primary and recurrent BCC lesions with several markers and investigates the role of antitumor immunity on BCC recurrence.

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Section: Discussioncontrasting

confidence: 63%

Sparsity of dendritic cells and cytotoxic T cells in tumor microenvironment may lead to recurrence in basal cell carcinoma

et al. 2020

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“…This may impact on the response to treatment as well as on original tumour development although this is not known with certainty in humans and requires further research. 13,14 Our observations in pathological and healthy 10 skin may at least partly explain the recently reported local PDT-induced immunosuppression in human skin. 9 The reduced Langerhans cell numbers may be attributable to migration of cells from the epidermis to the local lymph node, as reported in mice, 7 potentially mediated by tumour necrosis factor-a, which is observed to be upregulated following topical ALA-PDT in humans.…”

Section: Discussionmentioning

confidence: 55%

“…Thus, lack of Langerhans cells may reduce the efficiency of antigen presentation and activation of the antitumour T‐cell response. This may impact on the response to treatment as well as on original tumour development although this is not known with certainty in humans and requires further research 13,14 …”

Section: Discussionmentioning

confidence: 99%

Topical photodynamic therapy significantly reduces epidermal Langerhans cells during clinical treatment of basal cell carcinoma

Evangelou

Farrar

Cotterell

et al. 2012

British Journal of Dermatology

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“…Using ATPase method of staining LCs, Alcalay et al analysed the sensitivity of LCs to simulated solar radiation in patients with BCC and revealed that exposure to radiation resulted in a significant decrease of the number of ATPase-positive LCs [22], while Mardones et al used anti-CD1a antibody to compare the areas of epidermis overlying and adjacent to the BCC and showed the lower density of LCs in the epidermis overlying the tumour; Rotsztejn et al demonstrated a decreased number of LCs in BCC using the same staining [23,24]. In two studies published by Bergfelt et al, respectively, in 1992 and 1993, a reduction in density of LCs in epidermal sheets of BCC was documented with two different techniques.…”

Section: Resultsmentioning

confidence: 99%

Density of Langerhans Cells in Nonmelanoma Skin Cancers: A Systematic Review

Pogorzelska-Dyrbuś¹,

Szepietowski

2020

Mediators of Inflammation

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Langerhans cells (LCs) are bone marrow-derived dendritic cells (DCs) that represent 2-3% of the entire cell population of the human skin, known to have an ability to present antigens to T lymphocytes. Moreover, there is evidence that LCs are probably capable of inducing the local cytotoxic type T-cell-mediated response against the tumour-associated antigens. In the past two decades, a dramatic increase has been noted in the incidence of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The purpose of this study was to critically assess the results of available studies quantitatively assessing the LCs in nonmelanoma skin cancers and try to establish a conclusion of its possible impact on their future treatment. The PubMed, EMBASE, and the Web of Science databases were searched, which returned 948 citations. After a thorough analysis of full article texts, 30 studies have been chosen, including 11 of the BCC, 12 of the SCC specimens, and 7 analysing both tumour types. There was an overall trend towards slightly higher numbers of LCs in BCC than in SCC; however, these tendencies were discrepant between the studies. We presume that such differences could be caused by various staining techniques with a broad spectrum of specificity, including anti-S100, anti-CD1a, and ATPase activity staining used for LCs identification. We hypothesise that as there is a high inconsistency between the results of the studies, as far as the densities of LCs observed in the specimens are concerned, it seems that the mechanism of the influence of LCs on the antitumoural immune response is complicated. Finally, as at present, there is a paucity of available risk scores for the recurrence or progression of BCC or SCC, the creation of classification stratifying that risk including the density of LCs could bring additional information both for the physician and the patient.

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Decreased number of Langerhans cells in basal cell carcinoma

Cited by 5 publications

References 8 publications

Sparsity of dendritic cells and cytotoxic T cells in tumor microenvironment may lead to recurrence in basal cell carcinoma

Sparsity of dendritic cells and cytotoxic T cells in tumor microenvironment may lead to recurrence in basal cell carcinoma

Topical photodynamic therapy significantly reduces epidermal Langerhans cells during clinical treatment of basal cell carcinoma

Density of Langerhans Cells in Nonmelanoma Skin Cancers: A Systematic Review

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