T-cell rich angiomatoid polypoid pseudolymphoma: A novel cutaneous pseudolymphoma

Abstract

Cutaneous pseudolymphomas refer to a group of benign reactive T or B cell lymphoproliferative processes that simulate cutaneous lymphomas. T cell rich angiomatoid polypoid pseudo lymphoma (TRAPP) of the skin is a unique form of T cell rich cutaneous pseudolymphoma. A 13-year-girl presented with an asymptomatic skin colored papule on the right elbow, the biopsy of which revealed features consistent with TRAPP. The dermis showed an infiltrate of lymphocytes, plasma cells, and histiocytes along with prominent vascular channels lined by plump endothelium. An immunohistochemical study showed a predominance of T cells over B cells. The morphological and immunohistochemical features pointed towards the diagnosis of TRAPP. We report this rare entity, only 17 cases of which have been described so far in literature. The differential diagnoses have also been discussed.

Angiomatoid nodule of the breast

“…TRAPP is defined by its name as a cutaneous lymphoid proliferation that resembles a vascular tumor clinically and mimics a lymphoma histologically [1]. Only a few studies of TRAPP have been published in the literature so far [1,2]. Dayrit et al identified TRAPP in 2011 and described it in detail in their clinicopathological study of 17 patients [1].…”

Angiomatöser Knoten auf der Brust

“…Das T-Zell-reiche angiomatöse polypoide Pseudolymphom ist, wie der Name bereits sagt, eine kutane lymphoide Proliferation, die klinisch an einen vaskulären Tumor und histologisch an ein Lymphom erinnert [1]. Bisher gibt es in der Literatur nur wenige Veröffentlichungen zu dieser Entität [1,2]. Dayrit [7].…”

Phenytoin induced cutaneous B cell pseudolymphoma

“…Cutaneous pseudolymphomas are a group of benign reactive T-cell or B-cell lymphoproliferative processes of varying etiologies that can mimic lymphoma. [ 1 2 ] One of the precipitating factors for pseudolymphoma is drugs like anticonvulsants, antidepressants, angiotensin-converting enzyme inhibitors and antihistamines. [ 2 ] We report an 80-year-old male patient on phenytoin who presented with skin lesions resembling cutaneous lymphoma which showed complete resolution on withdrawal of the drug.…”