“…Evidence suggests that this toxicity was related to the Th-1, cytotoxic T-cell response (Schenk, 2002), which may be elicited by both the full length A and the QS-21 adjuvant that promotes a cell-mediated Th-1 immune response (Kensil et al, 1995). More recently, A-reactive T-cells have been detected in Alzheimer's patients and controls (Giubilei et al, 2003;Monsonego et al, 2003), and T-cell responses toward A fragments have been modulated with amino acid substitutions (Monsonego et al, 2003), supporting our approach (Sigurdsson et al, 2001;Knudsen et al, 2003).…”