Altered plasma cytokine levels in Alzheimer's disease: Correlation with the disease progression

Motta, Massimo; Imbesi, Rosa; Rosa, Michelino Di; Stivala, F; Malaguarnera, Mariano

doi:10.1016/j.imlet.2007.09.002

Cited by 150 publications

(139 citation statements)

References 41 publications

(43 reference statements)

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“…The only other study to assess IL-12 in a non-clinical elderly sample did not find such relationships (Baune et al 2008), however their sample was younger. Elevated levels of IL-12 have however been found in mild and moderate AD (Motta et al 2007). Longitudinal examination of the association with MCI and its subtypes in our sample may illuminate whether our association is specific for a pattern of cognitive performance heralding AD.…”

Section: Discussionmentioning

confidence: 63%

“…We included vascular adhesion molecule-1 (VCAM-1) as it has been found to be elevated in patients with dementia but has not been previously measured in a community sample (Dimopoulos et al 2006;Zuliani et al 2008). TNF-α, IL-1β, IL-10 and IL-12 were included on the basis of a consistent association with MCI (Alvarez et al 2007;Bermejo et al 2008) and dementia (Bagnoli et al 2007;Deniz-Naranjo et al 2008;Motta et al 2007). Plasminogen activator inhibitor-1 (PAI-1) and serum amyloid A (SAA) were included as they are activated by some of the previously mentioned inflammatory markers (Uhlar and Whitehead 1999;Soeda et al 2008).…”

mentioning

confidence: 99%

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The association between systemic inflammation and cognitive performance in the elderly: the Sydney Memory and Ageing Study

Trollor

Smith

Agars

et al. 2011

AGE

166

127

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Inflammation may contribute to cognitive decline and dementia. This study examined the cross-sectional relationships between markers of systemic inflammation (C-reactive protein, interleukins-1β, -6, -8, -10, -12, plasminogen activator inhibitor, serum amyloid A, tumour necrosis factor-α and vascular adhesion molecule-1) and cognitive function in 873 non-demented community-dwelling elderly participants aged 70-90 years. Regression analyses were performed to determine the relationships between cognitive domains and inflammatory markers, controlling for age, sex, education, cardiovascular risk factors, obesity and other metabolic factors, smoking, alcohol consumption, depression and presence of the apolipoprotein ε4 genotype. Regression analyses were repeated using four factors derived from a factor analysis of the cognitive tests. After Bonferroni correction for multiple testing, associations remained between raised levels of interleukin-12 and reduced performance in processing speed. Marked sex differences were noted in the abovementioned findings, with only females being significantly affected. Using the AGE

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Section: Discussionmentioning

confidence: 63%

mentioning

confidence: 99%

The association between systemic inflammation and cognitive performance in the elderly: the Sydney Memory and Ageing Study

Trollor

Smith

Agars

et al. 2011

AGE

166

127

View full text Add to dashboard Cite

show abstract

“…In this context, the microglia-derived Chit activity 48 could counterbalance the naturally occurring glucosamine aggregation as well as its transformation into detrimental chitin, thus having a protective rather than a detrimental role within the CNS. In contrast, deposition of chitin-like substances in the AD brain could result from a reduced immune response that characterises the most severe clinical expression of disease, 58 or from an impaired chitin cleavage in relation to the advanced age of AD patients.…”

Section: Discussionmentioning

confidence: 99%

Microglia and Chitotriosidase in Multiple Sclerosis

Sotgiu¹,

Musumeci²,

Marconi³

et al. 2008

European Neurological Review

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“…IL-12 increases production of pro-inflammatory cytokines. Some studies found no changes in the levels of IL-12 in the serum of patients with AD and FTD compared to controls [136], while other studies found a correlation between the plasma levels of IL-12 and severity of AD [137].…”

Section: Interleukin-4 (Il-4)mentioning

confidence: 97%

“…Motta et al showed that IL-16 levels depend on the severity of the AD [137]. IL-16 was elevated in the early stages of the disease, but reduced in the severe AD.…”

Section: Interleukin-16 (Il-16mentioning

confidence: 99%

Genetic and Blood Biomarkers of Alzheimer`s Disease

Momeni¹,

Ferrari²

2010

TONMEDJ

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Alzheimer's disease (AD) is the most prevalent form of dementia. AD is highly heritable, with a complex pattern. Although clinical diagnosis is based on accurate and well defined diagnostic criteria (NINCDS-ADRDA), the definite diagnosis relies on the postmortem pathological findings. The need for measures for the early detection of AD, as well as the need to distinguish between AD and other forms of dementia, has put great emphasis on the discovery of biomarkers for Alzheimer's disease. In clinical practice, there is need for non-invasive, accurate methods for the early detection and differential diagnosis of AD. The successful identification and development of the biomarkers, depends completely on the understanding of pathology, genetic and molecular mechanisms involved in the disease. As blood is a circulating dynamic tissue and transcription reflects the ongoing changes in the system, it makes the transcriptional profiling of the blood cells, potentially, the most sensitive source for transcriptional biomarkers. A systematic comparison of the genetic and proteomic blood biomarkers in patients and healthy controls can reveal additional potential candidates for AD. In the first part of this review, we would like to discuss the most recent genetic findings and their possible involvement in the pathogenesis of AD. In the second part, we review the blood biomarkers which can be derived from peripheral blood mononuclear cells (PBMC), serum, and plasma. We discus three main category of bio-molecules, namely DNA, RNA (miRNA and mRNA), and protein as well as their possible role in the hypothetical mechanisms involved in pathogenesis of AD. A dynamic interaction between the genetic findings through the whole genome association studies and biomarkers discovery can advance our knowledge of AD pathogenesis beyond the scope of each field independently.

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Altered plasma cytokine levels in Alzheimer's disease: Correlation with the disease progression

Cited by 150 publications

References 41 publications

The association between systemic inflammation and cognitive performance in the elderly: the Sydney Memory and Ageing Study

The association between systemic inflammation and cognitive performance in the elderly: the Sydney Memory and Ageing Study

Microglia and Chitotriosidase in Multiple Sclerosis

Genetic and Blood Biomarkers of Alzheimer`s Disease

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