2004
DOI: 10.1159/000076527
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T Cell Prolymphocytic Leukemia with New Chromosome Rearrangements

Abstract: A 77-year-old woman presented to the outpatient hematology clinic in August 2001 with leukocytosis, recurrent bacterial infections, sweating and weight loss. Bone marrow biopsy showed 80% infiltration with lymphoid cells having a prolymphocytic morphology. Flow-cytometric immunophenotype analysis showed that over 80% of the cells were positive for CD2, CD3, CD4, CD5 and CD7 antigens and negative for terminal deoxynucleotidyl transferase and CD1a antigens. T cell prolymphocytic leukemia (T-PLL) was diagnosed on… Show more

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Cited by 5 publications
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“…[5] Recently Campath-1H, an anti-CD52 humanised monoclonal antibody, has been found to be highly effective in T-PLL. [ 1,5,6,8] Responses have been noted in approximately two thirds of patients including those who have been refractory to treatment with deoxycoformycin. An effective treatment schedule recommended by Matutes is as follows: Deoxycoformycin followed by Campath-1H in patients who achieve partial response or are refractory to DCF.…”
Section: Discussionmentioning
confidence: 99%
“…[5] Recently Campath-1H, an anti-CD52 humanised monoclonal antibody, has been found to be highly effective in T-PLL. [ 1,5,6,8] Responses have been noted in approximately two thirds of patients including those who have been refractory to treatment with deoxycoformycin. An effective treatment schedule recommended by Matutes is as follows: Deoxycoformycin followed by Campath-1H in patients who achieve partial response or are refractory to DCF.…”
Section: Discussionmentioning
confidence: 99%