“…Interventions such as splenectomy, splenic irradiation, leucapheresis, and alkylating agents have been used to treat PLL but with disappointing results. CHOP chemotherapy (cyclophosphamide, doxorubicin, vincristine, prednisone) has shown a 30% response rate in patients studied, but eventually the disease reoccurred in all of those who had a favorable response (Ghosh & Advani, 2005). Purine nucleoside analogues (PNA) and deoxycoformycin (DCF) has been more successful in the treatment of these disorders, but most recently, monoclonal antibodies (MoAbs) have been found to be highly effective for the treatment of PLL (Ghosh & Advani, 2005).…”