T-cell phenotypes are associated with serum IgE levels in Amish and Hutterite children

Hrusch, Cara L.; Stein, Michelle M.; Gozdz, Justyna; Holbreich, Mark; Vercelli, Donata; Ober, Carole; Sperling, Anne I.

doi:10.1016/j.jaci.2019.07.034

Cited by 27 publications

(15 citation statements)

References 39 publications

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“…These conditions have a profound impact on the activity of the immune system, showing both increased innate and regulatory (adaptive) responses in children and adults of these rural communities. [55][56][57] Since these responses have fundamental roles…”

Section: Gut Microbiota the Gut-lung Axis And Immune Educationmentioning

confidence: 99%

Primary prevention of asthma: from risk and protective factors to targeted strategies for prevention

2020

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Asthma is a complex disease that often starts in childhood. Genomic and environmental factors as well as aberrant immune maturation early in life can contribute to the onset of disease, with great disparity over time and geographical regions. Epidemiological studies have scrutinised environmental exposures and attempted to translate these exposures into prevention strategies. Some approaches for patients with asthma have been successful (eg, smoking ban, the Finnish Asthma Programme), and primary prevention of wheeze in pre-school children (age 0-5 years) by the supplementation of vitamin D or fish oil, or both, to pregnant women seems promising. Several recent prevention initiatives are based on strong asthma-protective environmental microbial exposures associated with traditional rural lifestyles. Preclinical studies with various bacterial lysates, bacterial and dietary metabolites, or helminthic compounds have yielded promising results that await translation into clinical practice. Given the immense societal and individual burden of asthma, there is an urgent need to further develop novel strategies to eradicate the disease.

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Section: Gut Microbiota the Gut-lung Axis And Immune Educationmentioning

confidence: 99%

Primary prevention of asthma: from risk and protective factors to targeted strategies for prevention

2020

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“…The complex microbiota of vertebrates is necessary, both in order to populate the symbiotic microbiotas, notably in the gut, and in order to provide signals and data described below ( 17 – 20 ). The resident microbiota also provides metabolites with profound effects on our physiology and on the development of most, perhaps all, organs ( 21 ).…”

Section: Evolution Of Relationship To Microbesmentioning

confidence: 99%

Evolution, the Immune System, and the Health Consequences of Socioeconomic Inequality

Rook

2022

mSystems

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“…An increase in expression of ILT3 on monocytes was associated with increased frequency of activated T reg cells, identified as CD45RO + and ICOS + . 66 Furthermore, A20 expression in monocytes was found to be negatively correlated with IgE levels in Amish but not Hutterite children. The mechanism linking a hyperinflammatory monocyte phenotype to type 2 cells and T reg cells was investigated.…”

Section: Figure 2 the Relationship Between Early Life Exposures Immune Development And Allergic Disease Susceptibility Exposures As Earlymentioning

confidence: 94%

Role of innate immunity and myeloid cells in susceptibility to allergic disease

Noel

Berin

2021

Annals of the New York Academy of Sciences

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Allergic diseases, including asthma, food allergy, eczema, and allergic rhinitis, are common diseases increasing in prevalence. Allergy, a failure of immune tolerance to innocuous environmental allergens, is characterized by allergen-specific immune responses, including IgE antibodies and T helper and T follicular helper cells producing type 2 cytokines. Despite the central role of adaptive immunity in pathophysiology of allergy, there is a growing body of evidence indicating an important role for the innate immune system in allergic disease. In this review, we focus on epithelial-mononuclear phagocyte communication in the control of allergy and tolerance. We discuss studies on early life environmental exposures and allergy susceptibility, and the evidence for innate training of mononuclear phagocytes as the mechanistic link between exposure and health or disease.

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T-cell phenotypes are associated with serum IgE levels in Amish and Hutterite children

Cited by 27 publications

References 39 publications

Primary prevention of asthma: from risk and protective factors to targeted strategies for prevention

Primary prevention of asthma: from risk and protective factors to targeted strategies for prevention

Evolution, the Immune System, and the Health Consequences of Socioeconomic Inequality

Role of innate immunity and myeloid cells in susceptibility to allergic disease

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