T cell metabolism in autoimmune diseases

Li, Dan; Piccioni, Miranda; Gao, Zhen; Chen, Zuojia Chen Chen; Nie, Jia; Shan, Zhao; Li, Yangyang; Tsun, Andy; Li, Bin

doi:10.5772/47749

Cited by 3 publications

(4 citation statements)

References 125 publications

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“…Hence, their metabolic status is generally at baseline. These cells use autophagy and catabolism of fatty acids to supply their housekeeping demands (80). When these cells are activated, they undergo rapid and excessive clonal expansion.…”

Section: Metabolism Of Th Cellsmentioning

confidence: 99%

“…Activated Th cells use anabolism to synthesize different types of essential macromolecules for proliferation, which is highly energetically costly. In fact, activated Th cells switch from catabolism to anabolism, a process known as metabolic reprogramming (80).…”

Section: Metabolism Of Th Cellsmentioning

confidence: 99%

“…Levels of several metabolites [amino acids (83, 84) and glucose], growth factors, energy level (cytosolic AMP:ATP ratio), stress, and immunological signals [CD28, IL-2 (82)] regulate mTOR function (Figure 3) (83). At the same time, mTOR controls expression of several nutrition transporters (80). Different cytokines also regulate mTOR activity; IL-7 activates mTOR and inhibits autophagy, IL-4 promotes proliferation through mTOR activation and decrease apoptosis, IL-12 and IFN-γ also promote continuous mTOR activity (82).…”

Section: Mtor; Mechanistic Target Of Rapamycinmentioning

confidence: 99%

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Immunomodulatory Effects of Flavonoids: Possible Induction of T CD4+ Regulatory Cells Through Suppression of mTOR Pathway Signaling Activity

et al. 2019

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The increasing rate of autoimmune disorders and cancer in recent years has been a controversial issue in all aspects of prevention, diagnosis, prognosis and treatment. Among dietary factors, flavonoids have specific immunomodulatory effects that might be of importance to several cancers. Over different types of immune cells, T lymphocytes play a critical role in protecting the immune system as well as in the pathogenesis of specific autoimmune diseases. One of the important mediators of metabolism and immune system is mTOR, especially in T lymphocytes. In the current review, we assessed the effects of flavonoids on the immune system and then their impact on the mTOR pathway. Flavonoids can suppress mTOR activity and are consequently able to induce the T regulatory subset.

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Section: Metabolism Of Th Cellsmentioning

confidence: 99%

Section: Metabolism Of Th Cellsmentioning

confidence: 99%

Section: Mtor; Mechanistic Target Of Rapamycinmentioning

confidence: 99%

See 1 more Smart Citation

Immunomodulatory Effects of Flavonoids: Possible Induction of T CD4+ Regulatory Cells Through Suppression of mTOR Pathway Signaling Activity

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Levels of several metabolites [amino acids (83,84) and glucose], growth factors, energy level (cytosolic AMP:ATP ratio), stress, and immunological signals [CD28, IL-2 (82)] regulate mTOR function (Figure 3) (83). At the same time, mTOR controls expression of several nutrition transporters (80). Different cytokines also regulate mTOR activity; IL-7 activates mTOR and inhibits autophagy, IL-4 promotes proliferation through mTOR activation and decrease apoptosis, IL-12 and IFN-γ also promote continuous mTOR activity (82).…”

Section: Mtor; Mechanistic Target Of Rapamycinmentioning

confidence: 99%