T-Cell Lymphoma in a Patient with Neurofibromatosis Type 1 and AIDS

Abstract

Neurofibromatosis type 1 (NF1) and AIDS are risk factors for the development of malignant neoplasms, including hematological malignancies, such as non-Hodgkin lymphoma. NF1 is an autosomal dominant disease that primarily manifests as café-au-lait spots, dermal neurofibromas, axillary and/or inguinal ephelides or freckles, plexiform neurofibromas, Lisch nodules, and bone deformities. In this report, we present a 38-year-old female patient with NF1 from childhood and AIDS who developed peripheral T-cell lymphoma with good response to chemotherapeutic treatment.

Neurofibromatosis and HIV in a pregnant woman

“…Neurofibromatosis type 1 (NF1) or Von Recklinghausen disease is a rare autosomal dominant syndrome occurring in approximately 1:3,000 births (1). It is due to gene mutation of proximal long arm of chromosome 17 with the loss of neurofibromin protein, that is involved in activation protein for RAS (4). The mutation is sporadic in about 50% of cases.…”

Further Lessons Learned From a Child With NF1 and Classical Hodgkin Lymphoma

“…Patients with neurofibromatosis type 1 (NF1) have a 5- to 10-fold increase in relative risk of non-Hodgkin lymphoma 1–5. Hodgkin lymphoma (HL) in a patient with NF1 is a rare occurrence, with only 4 such cases reported 6–9.…”