T-Cell Large Granular Lymphocyte Leukemia: An Interdisciplinary Issue?

Schreiber, Johanna; Pichler, Alexander; Kornauth, Christoph; Kaufmann, H.; Staber, Philipp B.; Hopfinger, Georg

doi:10.3389/fonc.2022.805449

Cited by 2 publications

(4 citation statements)

References 47 publications

(92 reference statements)

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“…LGL proliferation such as viral infections (e.g. human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), CMV, EBV), lymphomas, and solid tumors should be excluded, as was done in this patient [4].…”

Section: A Diagnosis Of T-mentioning

confidence: 99%

“…T-LGL leukemia is not a curable disease but usually has an indolent course, with overall survival of 70% at 10 years [4]. Deaths mainly result from severe infections [7].…”

Section: A Diagnosis Of T-mentioning

confidence: 99%

“…Deaths mainly result from severe infections [7]. Treatment, which is based on immunosuppressive drugs, is often not required as only half of patients need treatment at the time of diagnosis [4]. When needed, it aims to relieve symptoms and reduce infections as well as blood transfusion needs.…”

Section: A Diagnosis Of T-mentioning

confidence: 99%

“…When needed, it aims to relieve symptoms and reduce infections as well as blood transfusion needs. Active treatment is only indicated in case of symptomatic disease or severely impaired blood cell counts: neutrophils <0.5x10 3 cells/μL, neutropenia-associated infections, hemoglobin <10 g/dL or transfusion needs, platelets <50x10 9 cells/L, symptomatic autoimmune disease, symptomatic splenomegaly and severe Bsymptoms [4,8].…”

Section: A Diagnosis Of T-mentioning

confidence: 99%

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Febrile Neutropenia as the First Manifestation of T-Cell Large Granular Lymphocytic Leukemia

Martins¹,

Silva²,

Gomes³

et al. 2022

Cureus

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T-cell large granular lymphocytic (T-LGL) leukemia is a rare lymphoproliferative disorder, characterized by peripheral blood and bone marrow infiltration with large granular lymphocytes (LGL), splenomegaly, cytopenias, and a frequent association with autoimmune diseases. Recurrent bacterial infections due to neutropenia are the main reason why patients come to medical attention. Despite not being a curable disease, T-LGL leukemia usually has an indolent course, with deaths mainly resulting from severe infections. Treatment is often not required, however, when needed, aims to relieve symptoms, and reduce infections and transfusion needs.We describe a case of an 86-year-old female patient with febrile neutropenia, diagnosed with T-LGL leukemia after the resolution of infection and exclusion of other causes of neutropenia. A "watch and wait" approach was established after a multidisciplinary discussion.This case shows a frequent presentation of a rare disease, as well as the approach from diagnosis to treatment, reminding clinicians that T-LGL leukemia should be considered in the differential diagnosis of adults with febrile neutropenia.

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Section: A Diagnosis Of T-mentioning

confidence: 99%

“…T-LGL leukemia is not a curable disease but usually has an indolent course, with overall survival of 70% at 10 years [4]. Deaths mainly result from severe infections [7].…”

Section: A Diagnosis Of T-mentioning

confidence: 99%

Section: A Diagnosis Of T-mentioning

confidence: 99%

Section: A Diagnosis Of T-mentioning

confidence: 99%

See 2 more Smart Citations

Febrile Neutropenia as the First Manifestation of T-Cell Large Granular Lymphocytic Leukemia

Martins¹,

Silva²,

Gomes³

et al. 2022

Cureus

View full text Add to dashboard Cite

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T-Large Granular Lymphocytic Leukemia with Hepatosplenic T-Cell Lymphoma? A Rare Case of Simultaneous Neoplastic T-Cell Clones Highlighted by Flow Cytometry and Review of Literature

Libonati,

Soda,

Statuto

et al. 2024

Biomedicines

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Lymphoproliferative diseases are a heterogeneous set of malignant clonal proliferations of lymphocytes. Despite well-established diagnostic criteria, the diagnosis remains difficult due to their variety in clinical presentation and immunophenotypic profile. Lymphoid T-cell disorders are less common than B-cell entities, and the lack of a clear immunophenotypic characteristic makes their identification hard. Flow cytometry turned out to be a useful tool in diagnosing T-cell disorders and to resolve complicated cases, especially if the number of analyzable neoplastic cells is small. We present a case of a 55-year-old man with simultaneous lymphoproliferative neoplastic T-cell clones, one αβ and the other γδ, identified and characterized by flow cytometry (FC), exploiting the variable expression intensity of specific markers. However, the patient’s rapid decline made it impossible to define a differential diagnosis in order to confirm the identity of the γδ clone, which remains uncertain. This case is added to the few other cases already documented in the literature, characterized by the co-existence of T-large granular lymphocytic leukemia (T-LGLL)-αβ and T-LGLL-γδ/Hepatosplenic T-cell lymphoma (HSTCL). Our case underlines the key role of sensitive diagnostic tools in the assessment of potential relationship between the diagnosis, prognosis, and treatment in the two pathologies.

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T-Cell Large Granular Lymphocyte Leukemia: An Interdisciplinary Issue?

Cited by 2 publications

References 47 publications

Febrile Neutropenia as the First Manifestation of T-Cell Large Granular Lymphocytic Leukemia

Febrile Neutropenia as the First Manifestation of T-Cell Large Granular Lymphocytic Leukemia

T-Large Granular Lymphocytic Leukemia with Hepatosplenic T-Cell Lymphoma? A Rare Case of Simultaneous Neoplastic T-Cell Clones Highlighted by Flow Cytometry and Review of Literature

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