t-BOOH-induced oxidative damage in sickle red blood cells and the role of flavonoids

Cesquini, Maristela; Torsoni, Márcio Alberto; Stoppa, Graziela R.; Ogo, Satie Hatsushika

doi:10.1016/s0753-3322(03)00018-0

Cited by 79 publications

(61 citation statements)

References 35 publications

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“…Antioxidants, both exogenous and endogenous, whether synthetic or natural, can be effective in preventing free radical formation by scavenging and suppressing such disorders [11,[12][13][14]. Currently, there is a growing interest toward natural antioxidants of herbal resources [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

“…Currently, there is a growing interest toward natural antioxidants of herbal resources [10][11][12]. Epidemiological and in vitro studies on medicinal plants and vegetables strongly supported this idea that plant constituents with antioxidant activity are capable of exerting protective effects against oxidative stress in biological systems [13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

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Screening of antioxidant activity of lichens Parmotrema reticulatum and Usnea sp. from Darjeeling hills, India

Sharma¹

2012

iosrphr

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Abstract--Till date many plants have been screened for their antioxidant activity. Oxidative stress can lead to the production of free radicals which may cause many degenerative diseases. These free radicals can be eliminated with the help of antioxidants which may be of a natural origin. The aim of this study was to examine the antioxidant activity of two common lichens namely Parmotrema reticulatum and Usnea sp from Darjeeling hills. The antioxidant assay of different concentration of ethanolic and methanolic extracts of lichens was determined with respect to five parameters i. e., DPPH radical scavenging activity, total antioxidant activity, reducing power ability, flavonoid and phenolic content. The DPPH radical scavenging ranged from 10% to 31.5% for methanol extracts of Parmotrema reticulatum and Usnea sp respectively and for reducing power measured values of absorbance varied from 0.376 to 0.514. In addition, total phenolic content of the extracts were high and total flavonoids content was moderate. Tested lichen species were found to possess considerable antioxidant activities and could be evaluated as good natural sources of antioxidants.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Screening of antioxidant activity of lichens Parmotrema reticulatum and Usnea sp. from Darjeeling hills, India

Sharma¹

2012

iosrphr

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“…Flavonoids and isoflavonoids have potent antioxidant activity relavent to cancer. 50,51) Glycoside linked flavonoids are responsible for antioxidant effects. 43) Isoflavonoids play an important role in prevention of breast cancer, prostrate cancer and atherosclerosis.…”

Section: Resultsmentioning

confidence: 99%

Therapeutic Efficacy of Kalpaamruthaa on Lipid Peroxidation and Antioxidant Status in Experimental Mammary Carcinoma in Rats

Ramprasath

Shanthi

Sachdanandam

2006

JOURNAL OF HEALTH SCIENCE

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There has been a growing interest in studying the role played by lipid peroxidation and antioxidant status in breast cancer. Free radicals are found to be involved in both initiation and promotion of multistage carcinogenesis. In the present study, effects of Kalpaamruthaa (KA), a modified Siddha preparation on the levels of lipid peroxides (LPO) and status of antioxidants in several tissues were studied in mammary carcinoma rats. The levels of reactive oxygen species (ROS) were also measured in the control and experimental animals. A significant increase in the levels of LPO, ROS and a decreased levels of antioxidants observed in mammary carcinoma bearing rats were found to be reverted back to near normal levels on treatment with KA. Simultaneous treatment with KA showed more effect than post treatment with KA. Drug control animals showed no significant changes in the levels of ROS when compared with control animals. These results suggest that the free radical mediated damage during mammary carcinoma could have been controlled by KA by its free radical quenching and antioxidative potential. The above results also show that KA exert its anticancer effect on the development of breast cancer.

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“…7 Therefore, medicinal plants can be a potential source of natural antioxidants. 8 As part of our ongoing research with medicinal plant of Bangladesh 9-10 the present study has been undertaken to evaluate the membrane stabilizing and cytotoxic activities of O. indicum leaf and bark extracts as well as to find out the logical evidence for folkloric uses of this plant.…”

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confidence: 99%

Membrane Stabilizing and Cytotoxic Activities of Different Kupchan Partitionates of Oroxylum indicum (L.) Vent. Leaf and Bark Extracts

Aktar

Kuddus

Kabir

et al. 2014

Dhaka Univ. J. Pharm. Sci

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The methanol extract of the leaf and bark of Oroxylum indicum (L.) Vent. and their different organic soluble partitionates were screened for membrane stabilizing and cytotoxic activities. Among all samples, the chloroform soluble fraction of crude methanol extract of leaf of O. indicum exhibited highest inhibition of haemolysis of RBC (72.22%) as compared to 82.22%, exerted by the standard acetyl salicylic acid (0.10 mg/ml). In brine shrimp lethality assay, the petroleum-ether soluble fraction of crude methanol extract of leaf and carbon tetrachloride soluble fraction of bark demonstrated strong cytotoxic activity with LC 50 value of 1.81 and 6.54 µg/ml, respectively, while standard vincristine sulphate produced LC 50 of 0.451 µg/ml. As part of our ongoing research with medicinal plant of Bangladesh 9-10 the present study has been undertaken to evaluate the membrane stabilizing and cytotoxic activities of O. indicum leaf and bark extracts as well as to find out the logical evidence for folkloric uses of this plant. O. indicum (FamilyThe leaf and bark of the plant were collected from Khagrachari district in 2010. A voucher specimen for this plant has been maintained in Bangladesh National Herbarium, Dhaka, Bangladesh for future reference. The bark was cut into small pieces and both bark and leaves were sun dried for 7 days followed by oven drying for 24 hours at 40 °C to facilitate proper grinding.The powdered materials (500 g of each for leaf and bark) were separately soaked in 1.5 L of methanol in a large conical flask for 7 days with occasional shaking and stirring. The whole mixture was then filtered off through a cotton plug followed by Whatman filter paper no.1 and the filtrate thus obtained was concentrated with the help of a rotary evaporator. An aliquot (5.0 g) of the concentrated methanol extract of both samples was separately fractionated by the modified Kupchan partitioning protocol 11 which afforded petroleum-ether (450.0

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t-BOOH-induced oxidative damage in sickle red blood cells and the role of flavonoids

Cited by 79 publications

References 35 publications

Screening of antioxidant activity of lichens Parmotrema reticulatum and Usnea sp. from Darjeeling hills, India

Screening of antioxidant activity of lichens Parmotrema reticulatum and Usnea sp. from Darjeeling hills, India

Therapeutic Efficacy of Kalpaamruthaa on Lipid Peroxidation and Antioxidant Status in Experimental Mammary Carcinoma in Rats

Membrane Stabilizing and Cytotoxic Activities of Different Kupchan Partitionates of Oroxylum indicum (L.) Vent. Leaf and Bark Extracts

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