T-bet+ Cells Polarization in Patients Infected with Helicobacter pylori Increase the Risk of Peptic Ulcer Development

Bagheri, Nader; Shirzad, Hedayatollah; Mirzaei, Yousef; Nahid‐Samiei, Mahboobeh; Rahimian, Ghorbanali; Shafigh, Mohammadhadi; Zandi, Farid; Tahmasbi, Kamran; Razavi, Alireza

doi:10.1016/j.arcmed.2019.07.005

Cited by 16 publications

(16 citation statements)

References 29 publications

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“…Predominant 17 expression was positively correlated with the degree of immunopathologic reactions resulting in peptic ulcers [6]. Furthermore, increasing of T-bet + cells and the mucosal INF-c expression related to the degree of H. pylori density in infected patients can lead to ulcer or GC [7]. In addition, the roles of babA2 and oipA proteins might have the potential to exert pressure on H. pylori by enhancing the production of free radicals that cause mutations in target cells and the neoplastic clones are established [39].…”

Section: Discussionmentioning

confidence: 97%

“…ese different clinical outcomes have been attributed to the interplay of several factors, including virulence factors of H. pylori, host genetic susceptibility, and host immune responses to H. pylori infection [5][6][7]. Several virulence factors have been proposed for H. pylori infections; they include adapting to different tissues like urease and flagella, using adhesins such as blood-antigen binding protein A (BabA) and outer inflammatory protein A (OipA), and toxins that damage host tissues such as cytotoxin-associated gene A (CagA) and vacuolating cytotoxin (VacA).…”

Section: Introductionmentioning

confidence: 99%

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Precancerous Gastric Lesions with Helicobacter pylori vacA⁺/babA2⁺/oipA⁺ Genotype Increase the Risk of Gastric Cancer

Bartpho

Wattanawongdon

Tongtawee

et al. 2020

BioMed Research International

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Objective. The clinical outcomes of gastric diseases such as chronic gastritis, peptic ulcer, and gastric cancer have been attributed to the interplay of virulence factors of Helicobacter pylori (H. pylori), host genetic susceptibility, and host immune responses. This study investigated the presence of cagA, vacA, iceA2, babA2, and oipA genes and their association with clinical outcomes. Methods. Chronic gastritis, atrophic gastritis, and intestinal metaplasia specimens were obtained from patients who underwent endoscopy and surgical resection between January 2017 and December 2018; specimens from gastric cancer patients treated between January 2014 and December 2018 were also added. H. pylori infection and virulence genes (cagA, vacA, iceA2, babA2, and oipA) were determined using real-time PCR. The association between H. pylori genotypes and clinical outcomes were evaluated using multivariate regression model analysis. The overall survival of gastric cancer patients was compared between genotype combinations. Results. H. pylori was positive in 166 patients with chronic gastritis, precancerous gastric lesions, and gastric cancer. The genes vacA, babA2, and oipA were most prevalent in chronic gastritis (73%), precancerous gastric lesions (62%), and gastric cancer (91%), respectively. The vacA, babA2, and oipA genes were associated with increased risk of gastric cancer (OR = 1.23; 95% CI = 1.13–3.32; P=0.033, OR = 2.64; 95% CI = 1.44–4.82, P=0.024, and OR = 2.79; 95% CI = 1.58–5.41; P=0.031, respectively). Interestingly, H. pylori vacA+/babA2+/oipA+ genotype infection was associated with increased risk of gastric cancer (OR = 3.85, 95% CI = 1.67–5.77, P=0.014). Conclusion. In this present study, we reported on the virulence genes of H. pylori infection to reveal their association with increased risk of chronic gastritis, precancerous gastric lesions, and gastric cancer. Precancerous gastric lesions with H. pylori vacA+/babA2+/oipA+ genotype increased the risk of gastric cancer.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Precancerous Gastric Lesions with Helicobacter pylori vacA⁺/babA2⁺/oipA⁺ Genotype Increase the Risk of Gastric Cancer

Bartpho

Wattanawongdon

Tongtawee

et al. 2020

BioMed Research International

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“…T-bet + cells and INF-γ expression also have similar response as of Th17 cells. Interestingly, the number of T-bet + cells was positively associated with Th17 cell counts whereas there is an inverse association with cell count of Treg cells but all of them leads to increase in bacterial density [27].…”

Section: Discussionmentioning

confidence: 94%

Prevalence of Tumor necrosis factor alpha inducing protein (tipα) gene of Helicobacter pylori and its association with Upper Gastrointestinal Diseases in India

Mahant¹,

Mehra²,

Chhawchharia³

et al. 2020

Preprint

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Background: Helicobacter pylori (H. pylori) is known to cause several gastro-duodenal diseases including chronic Gastritis, Peptic Ulcer disease and Gastric Cancer. Virulent genes of H. pylori like cagA, vacA are known to be responsible for the disease pathogenesis. But these virulence genes are not always found to be associated with disease outcome in all populations around the world. Relationship of H. pylori with Gastro Esophageal Reflux Diseases is controversial and uncertain. Tumor necrosis factor alpha inducing protein tipα is a new discovered virulent gene of H. pylori and is an inducer of certain cytokines and chemokines that are responsible for causing stomach cancer. Therefore, we conducted a study which aims to find the prevalence of tipα gene in the Indian population and its association with H. pylori related upper gastrointestinal diseases.Results: 267 clinical H. pylori isolates are included in our study for finding the prevalence of tipα gene and its association with cagA and vacA gene using PCR assay. The current study shows the prevalence rate of tipα gene in the Indian population to be 59.9%. Our study has found a significant association (p < 0.05) of tipα gene with Non Ulcer Dyspepsia (NUD) and also an association of cagA and vacA s1m1 with Gastritis and Duodenal Ulcer.Conclusion: Our study demonstrates for the first time the presence of tipα as virulent factor of H. pylori strain in Indian population isolated from patients suffering from upper gastrointestinal diseases. Further, tipα is significantly associated with NUD but not with other upper gastrointestinal diseases in India.

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“…Bagheri et al found significantly higher numbers of T‐bet+ Th1 cells in gastric biopsies from peptic ulcer disease (PUD) patients, compared to those with gastritis 11 . The same group also reported increased gastric Th22 cells in PUD patients.…”

Section: Immunologymentioning

confidence: 95%

Review ‐ Helicobacter, inflammation, immunology and vaccines

Robinson

Lehours

2020

Helicobacter

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Understanding the mechanisms involved in induction and regulation of the immune and inflammatory response to Helicobacter pylori is extremely important in determining disease outcomes. H pylori expresses a plethora of factors that influence the host response. Vaccines against H pylori are desperately needed for the prevention of gastric carcinogenesis, especially with the increasing trends in antimicrobial resistance. This review summarizes some important findings, published between 1 April 2019 and 31 March 2020, in the areas of H pylori‐mediated inflammation, immunity and vaccines.

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T-bet+ Cells Polarization in Patients Infected with Helicobacter pylori Increase the Risk of Peptic Ulcer Development

Cited by 16 publications

References 29 publications

Precancerous Gastric Lesions with Helicobacter pylori vacA⁺/babA2⁺/oipA⁺ Genotype Increase the Risk of Gastric Cancer

Precancerous Gastric Lesions with Helicobacter pylori vacA⁺/babA2⁺/oipA⁺ Genotype Increase the Risk of Gastric Cancer

Prevalence of Tumor necrosis factor alpha inducing protein (tipα) gene of Helicobacter pylori and its association with Upper Gastrointestinal Diseases in India

Review ‐ Helicobacter, inflammation, immunology and vaccines

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T-bet+ Cells Polarization in Patients Infected with Helicobacter pylori Increase the Risk of Peptic Ulcer Development

Cited by 16 publications

References 29 publications

Precancerous Gastric Lesions with Helicobacter pylori vacA+/babA2+/oipA+ Genotype Increase the Risk of Gastric Cancer

Precancerous Gastric Lesions with Helicobacter pylori vacA+/babA2+/oipA+ Genotype Increase the Risk of Gastric Cancer

Prevalence of Tumor necrosis factor alpha inducing protein (tipα) gene of Helicobacter pylori and its association with Upper Gastrointestinal Diseases in India

Review ‐ Helicobacter, inflammation, immunology and vaccines

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Product

Resources

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Precancerous Gastric Lesions with Helicobacter pylori vacA⁺/babA2⁺/oipA⁺ Genotype Increase the Risk of Gastric Cancer

Precancerous Gastric Lesions with Helicobacter pylori vacA⁺/babA2⁺/oipA⁺ Genotype Increase the Risk of Gastric Cancer