T(14;18)(q32;q21) involving IGH andMALT1 is a frequent chromosomal aberration in MALT lymphoma

Streubel, Berthold; Lamprecht, Andrea; Dierlamm, Judith; Cerroni, Lorenzo; Stolte, Manfred; Ott, German; Raderer, Markus; Chott, Andreas

doi:10.1182/blood-2002-09-2963

Cited by 452 publications

(309 citation statements)

References 31 publications

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“…7,[27][28][29][30] In MALT lymphoma, deregulation of the expression of MALT1 gene due to chromosomal translocations t(11;18)(q21; q21) and t(14;18)(q32;q21) seems to be one of the main pathogenic mechanisms leading to reduced apoptotic activity. 12,15,22,[31][32][33] In contrast to what has been described in gastric MALT lymphomas, our results did not indicate the presence of t (11;18). This translocation has been extensively examined in gastric MALT lymphomas and is associated with cases of a more advanced stage or those lacking responses to Helicobacter pylori eradication.…”

Section: Discussioncontrasting

confidence: 99%

“…Another translocation involving MALT1 and IgH genes, t(14;18) (q32;q21) has recently been described as occurring more frequently at sites considered to have a low incidence of t(11;18), such as skin and orbit. 12,33 In our series t(14;18)(q32;q21) was relatively more frequent and associated with p-IkBa, thus confirming the link with NF-kB activity. In this study, we have not assayed the presence of the recently described t(3;14)(p14.1;q32).…”

Section: Discussionsupporting

confidence: 83%

“…12,15,[31][32][33]35 The nuclear expression of bcl10 has been proposed as a surrogate of NF-kB activation after (11;18)(q21;q21), t(1;14)(p22;q32), while strong cytoplasmic expression has been linked with t(14;18)(q32;q21). 7,12,22,35,36 Strikingly, our data show a clear association between nuclear bcl10, increased expression of p-IkBa, and shorter time to failure. This, in addition to providing predictor parameters, suggests tentative therapeutic targets.…”

Section: Discussionmentioning

confidence: 99%

“…9,10 Nevertheless, there is increasing evidence to suggest that cases diagnosed with MALT lymphomas arising at different sites differ in the presence of infectious specific antigens-Helicobacter, Campylobacter, Borrelia, Chlamydia-promoting lymphoid cell proliferation, and in the frequency of chromosomal translocations such as t(11;18)(q21;q21), or the newly described t(14;18)(q32;q21) and t(3;14) (p14.1;q32). [10][11][12] As in the case of other extranodal lymphomas, most MALT lymphomas arising in the ocular adnexa have an indolent course with a favorable prognosis; 1,2 previous reports have demonstrated low local aggressivity with a reasonably good possibility of relapse control by radiotherapy. 13 This is in keeping with the findings from a large series of MALT lymphomas, which showed that the efficacy of treatment varied accordingly with the site, stage, and clinical status of patients.…”

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confidence: 99%

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Nuclear bcl10 expression characterizes a group of ocular adnexa MALT lymphomas with shorter failure-free survival

Franco

Camacho

Caleo³

et al. 2006

Modern Pathology

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Ocular adnexa B-cell lymphomas are a relatively rare group of extranodal lymphomas, marginal-zone B-cell lymphomas of mucosa-associated lymphoid tissue (MALT lymphomas) being the most frequent type at this location. As with other nongastrointestinal MALT lymphomas, ocular adnexa MALT lymphomas have distinct characteristics from those of the gastric MALT model, implying specific pathogenic events, which could be of interest in the prediction of clinical behavior and the choice between therapeutic options. In a series of 39 cases of ocular adnexa MALT lymphomas, studied using a tissue microarray, we observed that the most frequent alteration was related to apoptosis regulation. Thus, caspase 3 activity was completely abolished, and phosphorylated IjBa, a marker of NF-jB activation, showed increased expression, while cases with an increased number of large cells displayed increased expression of survivin and other cell-cycle-related proteins, such as cyclin A, cyclin E and Ki67, and p16 expression was reduced. There were no occurrences of t(11;18)(q21,q21), while 5/37 cases exhibited t(14;18)(q32;q21). Aberrant nuclear expression of bcl10 was observed in 11 cases, independently of the presence of translocations, and was significantly associated with phosphorylated IjBa expression and a reduced TdT-mediated biotin-dUTP nicked-end labeling apoptotic index. Moreover, patients with tumoral bcl10 nuclear expression showed shorter failure-free survival.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Nuclear bcl10 expression characterizes a group of ocular adnexa MALT lymphomas with shorter failure-free survival

Franco

Camacho

Caleo³

et al. 2006

Modern Pathology

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“…12 Four mutually exclusive and apparently sitespecific, chromosomal translocations have been implicated in the development and progression of extranodal marginal zone lymphoma of mucosaassociated lymphoid tissue. These extranodal marginal zone lymphoma-associated translocations, t(11;18)(q21;q21), 11,[13][14][15][16][17][18][19][20][21][22] t(1;14)(p22;q32), 13,14,23 t(14;18) (q32;q21) 14,15,24,25 and t(3;14)(p14.1;q32) 26 show substantial differences in prevalence at specific extranodal localizations. In addition, several studies have reported the presence of various cytogenetic numerical aberrations, including trisomy 3, 7, 12 and 18, in extranodal marginal zone lymphoma at different extranodal sites.…”

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T(14;18)(q32;q21) involving MALT1 and IGH genes occurs in extranodal diffuse large B-cell lymphomas of the breast and testis

et al. 2013

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Primary B-cell lymphoma of the testis, breast and thyroid are rare and data concerning cytogenetic aberrations at these extranodal sites are scarce. We examined the presence of extranodal marginal zone lymphomaassociated translocations, t(11;18)(q21;q21), t(1;14)(p22;q32), t(14;18)(q32;q21), t(3;14)(p14.1;q32) and numerical aberrations of chromosomes 1, 3, 12 and 18 by fluorescence in situ hybridization in 6 extranodal marginal zone lymphomas and 24 diffuse large B-cell lymphomas with (n ¼ 9) or without (n ¼ 15) marginal zone lymphoma components, with primary localizations in the breast (n ¼ 15), testis (n ¼ 9) and thyroid (n ¼ 6). We found t(14;18)(q32;q21), with breakpoints in IGH and MALT1, in one testicular diffuse large B-cell lymphoma and in two diffuse large B-cell lymphomas of the breast. No other translocations, amplifications or deletions involving IGH, BCL-10, BCL-2, MALT1 and IAP2 were detected. Numerical aberrations occurred in 67% of the lymphomas, 67% of extranodal marginal zone lymphomas, 56% of diffuse large B-cell lymphomas with marginal zone lymphoma components and in 73% of 'de novo' diffuse large B-cell lymphomas. These included 78% of testis, 67% of thyroid and 60% of breast lymphomas, and included mainly trisomy 18 (n ¼ 16), trisomy 3 (n ¼ 8) and trisomy 1 (n ¼ 3). One testicular diffuse large B-cell lymphoma harbored both t(14;18)(q32;q21) and trisomy 3. Our results indicate that at least a few cases of diffuse large B-cell lymphoma of the testis and the breast belong to the spectrum of extranodal marginal zone lymphoma. Modern Pathology (2013) 26, 421-427; doi:10.1038/modpathol.2012; published online 28 September 2012Keywords: B-cell lymphoma; FISH; IGH; MALT1; numerical chromosomal aberrations; translocations Primary B-cell lymphoma of the testis, breast and thyroid are rare, each accounting for between 0.5 and 2.5% of all non-Hodgkin's lymphomas (NHLs). [1][2][3][4][5][6] Diffuse large B-cell lymphoma is the most common histological entity at these extranodal sites. Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue, commonly found in extranodal sites devoid of native lymphoid tissue, like the stomach, lung, salivary gland, thyroid and ocular adnexa, occur infrequently in the breast and testis. Although extranodal marginal zone lymphoma and diffuse large B-cell lymphoma are considered distinct clinicopathological entities in the World Health Organization (WHO) classification, 7 many extranodal diffuse large B-cell lymphomas have derived from a background of extranodal marginal zone lymphoma. [8][9][10][11] We found that a large subgroup of primary testicular diffuse large B-cell lymphoma has marginal zone lymphoma components, including small cell components and lymphoepithelial lesions. 12 Four mutually exclusive and apparently sitespecific, chromosomal translocations have been implicated in the development and progression of extranodal marginal zone lymphoma of mucosaassociated lymphoid tissue. These extranodal marginal zone lymphoma-associated translocations, t(11...

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Primary Cutaneous Marginal Zone B-Cell Lymphoma

Hoefnagel

Vermeer²,

Jansen³

et al. 2005

Arch Dermatol

159

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T(14;18)(q32;q21) involving IGH andMALT1 is a frequent chromosomal aberration in MALT lymphoma

Cited by 452 publications

References 31 publications

Nuclear bcl10 expression characterizes a group of ocular adnexa MALT lymphomas with shorter failure-free survival

Nuclear bcl10 expression characterizes a group of ocular adnexa MALT lymphomas with shorter failure-free survival

T(14;18)(q32;q21) involving MALT1 and IGH genes occurs in extranodal diffuse large B-cell lymphomas of the breast and testis

Primary Cutaneous Marginal Zone B-Cell Lymphoma

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