Primary Cutaneous Marginal Zone B-Cell Lymphoma

Hoefnagel, J.J.; Vermeer, Maarten H.; Jansen, Patty M.; Heule, Freerk; Vader, Pieter; Sanders, C. J. G.; Gerritsen, Marinel; Geerts, Marie-Louise; Meijer, Chris J.L.M.; Noordijk, Evert M.; Willemze, Rein

doi:10.1001/archderm.141.9.1139

Cited by 161 publications

(28 citation statements)

References 29 publications

(29 reference statements)

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“…[93536373839] Up to 50% of patients experience cutaneous relapses, locally or at a distance, but these do not impair prognosis. [4041] Extracutaneous spread is quite rare, observable in <10% of patients, especially in the nonclass-switched subtype. [24]…”

Section: Primary Cutaneous Marginal Zone Lymphomamentioning

confidence: 99%

A literature revision in primary cutaneous B-cell lymphoma

et al. 2017

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The term “Primary Cutaneous B-Cell Lymphoma” (PCBCL) comprehends a variety of lymphoproliferative disorders characterized by a clonal proliferation of B-cells primarily involving the skin. The absence of evident extra-cutaneous disease must be confirmed after six-month follow-up in order to exclude a nodal non-Hodgkin's lymphoma (NHL) with secondary cutaneous involvement, which may have a completely different clinical behavior and prognosis. In this article, we have summarized the clinico-pathological features of main types of PCBCL and we outline the guidelines for management based on a review of the available literature.

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Section: Primary Cutaneous Marginal Zone Lymphomamentioning

confidence: 99%

A literature revision in primary cutaneous B-cell lymphoma

et al. 2017

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“…While it has frequent cutaneous relapses, it rarely causes extracutaneous dissemination [8, 10, 12]. pCMZL is associated with an excellent prognosis with 5-year survival rates ranging from 89 to 99% [4, 10, 12, 15]. …”

Section: Discussionmentioning

confidence: 99%

Breast Cancer Mimic: Cutaneous B-Cell Lymphoma Presenting as an Isolated Breast Mass

Taghavi

Zhang²,

Lindfors

et al. 2014

Case Rep Oncol

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Background: Primary cutaneous B-cell lymphoma typically localizes to the skin, and dissemination to internal organs is rare. Lymphomatous involvement of the breasts is also rare. We describe the clinical and radiological findings of an unusual case of primary cutaneous B-cell lymphoma presenting as an isolated breast mass without associated skin changes. Case Presentation: The patient was a 55-year-old Caucasian female who initially presented with cutaneous B-cell lymphoma around her eyes and forehead with recurrence involving the skin between her breasts. Three years after terminating treatment due to a lack of symptoms, she presented for an annual screening mammogram that found a new mass in her upper inner right breast without imaging signs of cutaneous extension. On physical examination, there were no corresponding skin findings. Due to the suspicious imaging features of the mass that caused concern for primary breast malignancy, she underwent a core biopsy which revealed cutaneous B-cell lymphoma. Conclusion: When evaluating patients with a systemic disease who present with findings atypical for that process, it is important to still consider the systemic disease as a potential etiology, particularly with lymphoma given its reputation as a great mimicker.

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“…For patients with PCMZL who have multifocal lesions, chlorambucil therapy and radiotherapy are suitable therapeutic options. In case of cutaneous relapses, the beneficial effects of treatment should carefully be weighed against the potential adverse effects (Hoefnagel et al 2005). …”

Section: Discussionmentioning

confidence: 99%

Primary MALT Type Skin Lymphoma—Is ‘Wait and See’ a Possible Strategy?

Delli

Zaraboukas

Mandekou‐Lefaki

2008

Clinical medicine. Oncology

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Primary cutaneous lymphomas are the second most common site of extranodal non-Hodgkin lymphoma. A specifi cally type named extranodal marginal zone B-cell lymphomas are indolent low-grade neoplasma.We report a case of a 42-year-old white man with multiple subcutaneous tumors located on the trunk and neck. The histopathological exam showed a non-epidermotropic, dense lymphocytic infi ltrate. Histologic, immunohistochemical and cytologenetic analysis diagnosed primary cutaneous B-cell lymphoma MALT type. Investigation for other extranodal MALT lymphoma gastrointestinal tract, lung, salivary and thyroid glands was negative. The patient refused radiotherapy, but he accepted every 6 months close follow-up. Over a seven years period, we noticed a progressively disappearance of the skin lesions.The necessity of aggressive treatment of this disease with excellent prognosis is discussed. The treatment necessity of primary cutaneous B-cell lymphoma MALT type is discussed.

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Primary Cutaneous Marginal Zone B-Cell Lymphoma

Cited by 161 publications

References 29 publications

A literature revision in primary cutaneous B-cell lymphoma

A literature revision in primary cutaneous B-cell lymphoma

Breast Cancer Mimic: Cutaneous B-Cell Lymphoma Presenting as an Isolated Breast Mass

Primary MALT Type Skin Lymphoma—Is ‘Wait and See’ a Possible Strategy?

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