Syzygium jambolanum and Cephalandra indica homeopathic preparations inhibit albumin glycation and protect erythrocytes: an in vitro study

Tupe, Rashmi S.; Kulkarni, Amruta; Adeshara, Krishna; Shaikh, Shamim; Shah, Nilesh; Jadhav, Arun Bhargav

doi:10.1016/j.homp.2015.02.009

Cited by 16 publications

(13 citation statements)

References 32 publications

(28 reference statements)

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“…A number of plant derived compounds showed hypoglycemic properties (Sefi, Fetoui, Makni, & Zeghal, 2010) such total phenols, flavonoids, terpenoids, and coumarins; reducing glucose levels and increasing the insulin amounts in plasma (Santosh Tupe et al, 2015).…”

Section: Glycation Reaction Induces Modifications Of Protein Second-mentioning

confidence: 99%

Glucose‐mediated protein glycation: Contribution of methanolic extract of Ceratonia siliqua L. in protection and in vitro potential inhibition of acetylcholinesterase

et al. 2019

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Chronic hyperglycemia presents the major etiology of diabetes mellitus and related complications mainly Alzheimer's disease, via the protein glycation and toxic products generated. In the current study, we investigated the eventual protective effect of the methanolic extract of Ceratonia siliqua L. (CsME) against glucose‐mediated glycation in serum bovine albumin. The multi‐stage glycation markers, namely fructosamines and advanced glycation end products (AGEs) levels were monitored along with measurement of thiol groups; moreover, the in vitro acetylcholinesterase (AChE) inhibition potential was carried out. HPLC was also assessed. Rutin was the main phenolic compound found in CsME. CsME showed a good capacity to inhibit AGEs, fructosamines and protected thiol groups against glycation. CsME exhibited a great AChE inhibition activity. In the present study, CsME prevented glucose‐induced protein glycation, it also exhibited a good inhibition of AChE, suggesting its DM complications such as memory troubles related to AD. Practical applications Neurodegenerative disorders ranging from memory troubles to Alzheimer's disease present the most diabetes mellitus complications and mainly attributed to protein glycation process. Currently, there is a strong trend to search for efficient natural sources of glycation and acetylcholinesterase inhibitors to replace the synthetic ones, whose secondary effects were shown. The present article tries to justify scientifically the wide use of Ceratonia siliqua L. in Moroccan folk medicine, demonstrating that the methanolic extract of leaves from this species presents a promising source of new natural compounds inhibiting acetylcholinesterase and acting in vitro against glycation generated compounds. Furthermore, for the first time, Rutin was the main phenolic compound found in this extract, these encouraging results should be coupled with further studies to integrate it in pharmaceutical formulations. As such, this paper should be of interest to a broad readership, including those interested in Biochemistry, Phytochemistry, pharmacology, and neurosciences.

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Section: Glycation Reaction Induces Modifications Of Protein Second-mentioning

confidence: 99%

Glucose‐mediated protein glycation: Contribution of methanolic extract of Ceratonia siliqua L. in protection and in vitro potential inhibition of acetylcholinesterase

et al. 2019

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“…Duwet (Syzygium cumini L.) is local name for Java plum, widely grown in many countries whose seed has been used for traditional medication, particularly to treat type-2 diabetes mellitus (Helmstadter, 2008;Kumar et al, 2010;Swami et al, 2012;Tupe et al, 2015). In several places in Indonesia, the seeds of subvar Genthong are roasted, ground, brewed and served as "Duwet coffee" for diabetes traditional treatment.…”

Section: Introductionmentioning

confidence: 99%

Determination of Antioxidant Activity and Phenolic Compounds of Methanolic Extract of Java Plum (Syzygium cumini Linn. (Skeel) Seed

Rohadi

Santoso

Raharjo

et al. 2017

IFNP

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Methanolic extract of Java plum (Syzygium cumini L.) seed (MEJS) is a potential source of natural antioxidant. As indicated by several in vitro measurements, the extract had strong DPPH (1,1 diphenyl, 2-picryl hydrazyl) and ABTS (2,2-azinobis, 3-ethylbenzothiazoline-6-sulphonate) radical scavenging activity, strong Ferric Reducing Antioxidant Power (FRAP) and moderate inhibition activity of linoleic acid oxidation. This study aimed to determine antioxidant activity and phenolic compound of Java Plum seed (Syzygium cumini L.) methanolic extract fractions. Phenolics compound identification using Thin Layer Chromatography (TLC) showed that all fractions (polar, semi-polar, and hydrolyzed semi-polar fraction) contained gallic acid, tannic acid and flavonol's rutin. HPLC-DAD analysis showed that its polar fraction contained 25 ppm flavonol's quercetine and 55181 ppm flavonol's (+)-catechin, ethyl acetate fraction contained 54 ppm flavonol's rutin and 528 ppm (+)-catechine, while hydrolyzed ethyl acetate fraction contained 404 ppm Rutin and 28692 ppm (+)-catechine.

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“…Traditional and complimentary medicines like herbal therapies are gaining importance over conventional therapies for the treatment of different diseases especially in non-communicable chronic diseases (Tupe et al 2015a). They are used for prevention of the disease, health promotion and health maintenance.…”

Section: Introductionmentioning

confidence: 99%

Attenuation of glycation-induced multiple protein modifications by Indian antidiabetic plant extracts

Tupe

Kemse

Khaire

et al. 2016

Pharmaceutical Biology

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Syzygium jambolanum and Cephalandra indica homeopathic preparations inhibit albumin glycation and protect erythrocytes: an in vitro study

Abstract: These homeopathic preparations especially Sj ф prevented glycation induced albumin modifications and subsequent toxicity in human eryrthrocytre in vitro. Further investigation of their potential as antiglycators is justified.

Cited by 16 publications

References 32 publications

Glucose‐mediated protein glycation: Contribution of methanolic extract of Ceratonia siliqua L. in protection and in vitro potential inhibition of acetylcholinesterase

Glucose‐mediated protein glycation: Contribution of methanolic extract of Ceratonia siliqua L. in protection and in vitro potential inhibition of acetylcholinesterase

Determination of Antioxidant Activity and Phenolic Compounds of Methanolic Extract of Java Plum (Syzygium cumini Linn. (Skeel) Seed

Attenuation of glycation-induced multiple protein modifications by Indian antidiabetic plant extracts

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