Syzygium Cumini Inhibits Growth and Induces Apoptosis in Cervical Cancer Cell Lines: A Primary Study

Barh, Debmalya

doi:10.3332/ecancer.2008.83

Cited by 25 publications

(24 citation statements)

References 49 publications

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“…Similarly, the effect of 50% methanol extract showed greater apoptosis in HeLa than SiHa cells. 110 Freeze-dried Jamun fruit pulp extract was found to inhibit cell proliferation and growth of MCF-7 cells and MDA-MB-231 breast cancer cells in a concentration-and time-dependent manner; however, it was less effective in the MCF-10A cells. Yet, the Jamun extract did not induce apoptosis in untransformed MCF-10A breast cancer cells, whereas it was quite effective in triggering apoptotic cell death in both MCF-7 cells and MDA-MB-231 breast cancer cells.…”

Section: Anticancer Activitymentioning

confidence: 99%

Phytochemical Composition and Pleotropic Pharmacological Properties of Jamun, Syzygium Cumini Skeels

Jagetia¹

2017

Journal of Exploratory Research in Pharmacology

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Plants have been employed as medicine since time immemorial, and there has been a recent resurgence in the use of plants as medicines due to their little or no toxicity at the doses used for treatment of different ailments. This review discusses in detail the phytochemical and pharmacological activities of Jamun (Syzygium cumini), a tree belonging to family Myrtaceae, which has been credited with several medicinal properties in the traditional system of medicine, the Ayurveda. The different properties attributed to Jamun are sweet, sour, astringent, acrid, refrigerant, carminative, diuretic, and digestive. Research and practical use in traditional medicinal systems have found Jamun to be effective in treating leucorrhoea, gastric disorders, fever, diabetes, piles, stomachache, wounds, and dental, digestive and skin disorders. Some compounds in Jamun have antioxidant, antimicrobial, antiallergic, antidiabetic, antihyperlipidemic, anticancer, gastroprotective, hepatoprotective, cardioprotective and radioprotective activity. Finally, Jamun has been found to contain phytochemicals including anthroquinones, alkaloids, catechins, flavonoids, glycosides, steroids, phenols, tannins, saponins and cardiac glycosides. The diverse activities of Jamun may be due to its abilities to scavenge free radicals, increase antioxidant status of cells by increasing glutathione, glutathione peroxidase, catalase and/or superoxide dismutase, and to attenuate lipid peroxidation. In addition, it also suppresses the transcription of peroxisome proliferator-activated receptor, Nuclear factor kappa B, cyclooxygenase, inducible nitric oxide synthase, tumor necrosis factor alpha and other proinflammatory cytokines, accompanied by the up-regulation of nuclear factor erythroid 2-related factor 2 transcription, which is involved in regulating the antioxidant status of the cells.

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Section: Anticancer Activitymentioning

confidence: 99%

Phytochemical Composition and Pleotropic Pharmacological Properties of Jamun, Syzygium Cumini Skeels

Jagetia¹

2017

Journal of Exploratory Research in Pharmacology

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“…Studies in the past one decade have also shown that Jamun possess antineoplastic [50]. Radioprotective [51][52][53][54] and chemopreventive effects [55] all of which are useful in the prevention and treatment of cancer.…”

Section: Medicinal Propertiesmentioning

confidence: 99%

“…The best effect was observed at 80 mg/kg but only when administered through the intraperitoneal route as 50% of the animals survived when compare to 22% in the oral route and none in the radiation alone cohorts. The intraperitoneal administration of the organic extract (dichloromethane-methane) of leaves (5,10,20,30,40,50,60 and 80 mg/kg b. wt.)…”

Section: Radioprotective Effectsmentioning

confidence: 99%

Jamun (<i>Syzygium cumini </i>(L.)): A Review of Its Food and Medicinal Uses

Swami¹,

Thakor²,

Patil³

et al. 2012

FNS

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Eugenia jambolana Lam., commonly known as black plum or "jamun" is an important medicinal plant in various traditional systems of medicine. It is effective in the treatment of diabetes mellitus, inflammation, ulcers and diarrhea and preclinical studies have also shown it to possess chemopreventive, radioprotective and antineoplastic properties. The plant is rich in compounds containing anthocyanins, glucoside, ellagic acid, isoquercetin, kaemferol and myrecetin. The seeds are claimed to contain alkaloid, jambosine, and glycoside jambolin or antimellin, which halts the diastatic conversion of starch into sugar. The present review has been primed to describe the existing data on the information on traditional and medicinal use.

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“…Pharmacological studies show that S. cumini species have several functions, among them, antioxidants, antibacterial, antifungal, anti-allergic, anti-inflammatory, anti-hyperlipidemic, gastroprotective, cardioprotective, hepatoprotective, anticancer, radioprotective and antidiarrhoeal (Jagetia and Baliga, 2002;Barh and Viswanathan, 2008;Chaturvedi et al, 2009;Schoenfelder et al, 2010;Patel et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Antidiarrhoeal and antispasmodic activity of leaves of Syzygium cumini L. (Myrtaceae) mediated through calcium channel blockage

Monteiro¹,

Carvalho²,

Marques³

et al. 2018

Afr. J. Pharm. Pharmacol.

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Syzygium cumini L. Skeels (Myrtaceae) commonly known as jambolan is used as traditional medicine to treat gastrointestinal disorders in children in Brazil. This work is one of the first to evaluate the antidiarrhoeal and antispasmodic activity of the standardized extract of S. cumini leaves (HESc) in experimental models in vitro and in vivo rodents. Mice pre-treated with HESc (100, 250 and 1000 mg/kg) and atropine (1.0 mg/kg) had reduced intestinal transit velocity of 11.0; 23.2 and19.1%, respectively compared to saline control (46.6±0.9). In isolated rats jejunum, HESc (50, 150 and 300 µg/mL) shifted to the right cumulative concentration-response curves to ACh with changing maximum effect (E max ), which is characteristic of non-competitive antagonism to ACh. HESc also promoted relaxation (E max 90.2±5.8%) in preparations pre-contacted with KCl (75 mM). Additionally, it reduced the maximal CaCl 2 -induced response in 15.4; 56.3 and 92.1% in a concentration-dependent manner. The study results show that HESc has an antidiarrhoeal and spasmolytic potential that can be partly explained by the reduction of intestinal transit velocity and blockage of the voltage-dependent calcium channels in the smooth intestinal muscle.

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Syzygium Cumini Inhibits Growth and Induces Apoptosis in Cervical Cancer Cell Lines: A Primary Study

Cited by 25 publications

References 49 publications

Phytochemical Composition and Pleotropic Pharmacological Properties of Jamun, Syzygium Cumini Skeels

Phytochemical Composition and Pleotropic Pharmacological Properties of Jamun, Syzygium Cumini Skeels

Jamun (<i>Syzygium cumini </i>(L.)): A Review of Its Food and Medicinal Uses

Antidiarrhoeal and antispasmodic activity of leaves of Syzygium cumini L. (Myrtaceae) mediated through calcium channel blockage

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Syzygium Cumini Inhibits Growth and Induces Apoptosis in Cervical Cancer Cell Lines: A Primary Study

Cited by 25 publications

References 49 publications

Phytochemical Composition and Pleotropic Pharmacological Properties of Jamun, Syzygium Cumini Skeels

Phytochemical Composition and Pleotropic Pharmacological Properties of Jamun, Syzygium Cumini Skeels

Jamun (&lt;i&gt;Syzygium cumini &lt;/i&gt;(L.)): A Review of Its Food and Medicinal Uses

Antidiarrhoeal and antispasmodic activity of leaves of Syzygium cumini L. (Myrtaceae) mediated through calcium channel blockage

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Jamun (<i>Syzygium cumini </i>(L.)): A Review of Its Food and Medicinal Uses