Systolic and diastolic blood pressure, prostate cancer risk, treatment, and survival. The PROCA‐<i>life</i> study

Stikbakke, Einar; Schirmer, Henrik; Knutsen, Tore; Støyten, Martin; Wilsgaard, Tom; Giovannucci, Edward; McTiernan, Anne; Eggen, Anne Elise; Haugnes, Hege Sagstuen; Richardsen, Elin; Thune, Inger

doi:10.1002/cam4.4523

Cited by 10 publications

(9 citation statements)

References 47 publications

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“…The Prostate Cancer throughout life (PROCA-life) study reported that men (>45 years) with systolic blood pressure > 150 mm Hg had a 35% increased risk of prostate cancer compared with men with systolic blood pressure <130 mm Hg. Prostate cancer patients with high systolic or diastolic blood pressure also had a significantly increased risk of death ( Stikbakke et al, 2022 ). A pooled cohort study recently suggested that elevated blood pressure is unlikely to be an important risk factor for prostate cancer ( Jochems et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Design and Implementation of Taizhou Integrated Prostate Screening

et al. 2022

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A community-based prostate cancer screening program was conducted to assess the morbidity and associated factors for prostate cancer among the subpopulation of men aged ≥50 years in Taizhou, China. Taizhou Integrated Prostate Screening (TIPS) is a large, observational, population-based study of prostate cancer screening data based on serum prostate-specific antigen (PSA) concentrations. A pilot census of all male residents aged 50 years or older was conducted in Luqiao District, one of the field sites of the TIPS cohort in the city of Taizhou, Zhejiang. The interviewer-administered questionnaire evaluated demographic characteristics and environmental exposure factors. A total of 1,806 out of 3,516 participants completed the questionnaire. The overall prevalence of PSA ≥4 ng/mL was 11.5%, and included participants at low risk (9.2%), moderate risk (1.7%), and high risk (0.6%). Participants aged 60–69, 70–79, and ≥80 years had a 2.7-fold, 4.2-fold, and 6.5-fold higher risk of elevated PSA, respectively, in comparison with those aged 50 to 59 years ( p < .001). Eighteen patients were diagnosed with prostate cancer, of whom 11 (61.1%) underwent radical surgery. This community-based PSA screening program indicated the results for early detection of prostate cancer among men aged ≥50 years. Early screening and appropriate clinical therapy for the management of prostate cancer are essential in this subpopulation.

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Section: Discussionmentioning

confidence: 99%

Design and Implementation of Taizhou Integrated Prostate Screening

et al. 2022

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“…Age at surgery (continuous), CAPRA-S (categorical), BMI (continuous), alcohol habits (categorical), and cholesterol levels (continuous) were included in the final models as covariates. We performed a stratified analysis via systolic blood pressure based on previous observations suggesting that elevated systolic blood pressure is associated with prostate cancer risk [ 44 ]. The proportional hazard assumption was assessed by visually controlling that the log minus log survival curves were parallel.…”

Section: Methodsmentioning

confidence: 99%

Expression of miR-24-1-5p in Tumor Tissue Influences Prostate Cancer Recurrence: The PROCA-life Study

Stikbakke

Wilsgaard

Haugnes

et al. 2022

Cancers

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The role of miR-24-1-5p and its prognostic implications associated with prostate cancer are mainly unknown. In a population-based cohort, the Prostate Cancer Study throughout life (PROCA-life), all men had a general health examination at study entry and were followed between 1994 and 2016. Patients with available tissue samples after a prostatectomy with curative intent were identified (n = 189). The tissue expression of miR-24-1-5p in prostate cancer was examined by in situ hybridization (ISH) in tissue microarray (TMA) blocks by semi-quantitative scoring by two independent investigators. Multivariable Cox regression models were used to study the associations between miR-24-1-5p expression and prostate cancer recurrence. The prostate cancer patients had a median age of 65.0 years (range 47–75 years). The Cancer of the Prostate Risk Assessment Postsurgical Score, International Society of Urological Pathology grade group, and European Association of Urology Risk group were all significant prognostic factors for five-year recurrence-free survival (p < 0.001). Prostate cancer patients with a high miR-24-1-5p expression (≥1.57) in the tissue had a doubled risk of recurrence compared to patients with low expression (HR 1.99, 95% CI 1.13–3.51). Our study suggests that a high expression of miR-24-1-5p is associated with an increased risk of recurrence of prostate cancer after radical prostatectomy, which points to the potential diagnostic and therapeutic value of detecting miR-24-1-5p in prostate cancer cases.

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“…Note that for senior men, PC is the most common cancer. It is observed in practice that most of the PC patients are affected with cardiovascular disease (CVD) and hypertension [2][3][4][5][6]. Therefore, PC patients are affected with over hypertension risk factors such as systolic blood pressure (SBP) and diastolic blood pressure (DBP) [6][7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

“…It is observed in practice that most of the PC patients are affected with cardiovascular disease (CVD) and hypertension [2][3][4][5][6]. Therefore, PC patients are affected with over hypertension risk factors such as systolic blood pressure (SBP) and diastolic blood pressure (DBP) [6][7][8][9][10][11][12]. The global agestandardized prevalence of over hypertension risk factors such as SBP ≥140 mmHg and DBP ≥90 mmHg in men was estimated as ≥20% in 2015 [12].…”

Section: Introductionmentioning

confidence: 99%

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Systolic Blood Pressure Explanatory Factors for Prostate Cancer Patients

Das

2022

CTOIJ

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The linkages between the prostate cancer (PC) biomarkers and hypertension risk factors such as systolic and diastolic blood pressure are controversial. The present article attempts to identify the systolic blood pressure (SBP) determinants of the PC patients. It is identified herein that mean SBP is higher at older ages (P<0.001) of PC patients than younger, and it is also over for cardiovascular disease (CVD) history (P=0.086) patients than normal. It is directly linked to diastolic blood pressure (DBP) (P<0.001) and primary tumor size (SZ) (P=0.005) of PC subjects. It is inversely linked to the serum prostatic acid phosphatase (PAP) (P=0.062). On the other hand, variance of SBP is more scattered for CVD history (P=0.018) patients than normal, and heart patients marked by electrocardiogram (EKG) (P=0.017) than normal and benign. Moreover, variance of SBP is inversely linked to DBP (P=0.009), serum haemoglobin (HG) (P=0.002), and PAP (P=0.005). The above SBP associations with other factors for PC subjects of the considered data set have been obtained by joint generalized linear models (JGLMs) method. Mean SBP is dependent on PC factors such as primary tumor size and PAP, while its variance is dependent on PAP only. For hypertension PC patients, care should be taken on CVD history of the patients, SBP, DBP and their primary tumor size only.

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Systolic and diastolic blood pressure, prostate cancer risk, treatment, and survival. The PROCA‐life study

Cited by 10 publications

References 47 publications

Design and Implementation of Taizhou Integrated Prostate Screening

Design and Implementation of Taizhou Integrated Prostate Screening

Expression of miR-24-1-5p in Tumor Tissue Influences Prostate Cancer Recurrence: The PROCA-life Study

Systolic Blood Pressure Explanatory Factors for Prostate Cancer Patients

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