Systems Biology-Based Investigation of Host–Plasmodium Interactions

Smith, Maren L.; Styczynski, Mark P.

doi:10.1016/j.pt.2018.04.003

Cited by 21 publications

(12 citation statements)

References 112 publications

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“…Genome-wide expression profiling is being increasingly applied to dissect the complex details of the host response to malaria infection 9 , 10 . As blood is the most accessible tissue in field studies, numerous field studies analyse blood transcriptomes as read-outs for anti-malarial immunity 11 – 13 .…”

Section: Background and Summarymentioning

confidence: 99%

Transcriptome analysis of blood and spleen in virulent and avirulent mouse malaria infection

et al. 2020

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Malaria is a devastating infectious disease and the immune response is complex and dynamic during a course of a malarial infection. Rodent malaria models allow detailed time-series studies of the host response in multiple organs. Here, we describe two comprehensive datasets containing host transcriptomic data from both the blood and spleen throughout an acute blood stage infection of virulent or avirulent Plasmodium chabaudi infection in C57BL/6 mice. The mRNA expression profiles were generated using Illumina BeadChip microarray. These datasets provide a groundwork for comprehensive and comparative studies on host gene expression in early, acute and recovering phases of a blood stage infection in both the blood and spleen, to explore the interaction between the two, and importantly to investigate whether these responses differ in virulent and avirulent infections.

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Section: Background and Summarymentioning

confidence: 99%

Transcriptome analysis of blood and spleen in virulent and avirulent mouse malaria infection

et al. 2020

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“…Finally, comprehending the complexity of human immune effector mechanisms in malaria may necessitate a systems biology approach. Such a framework could be used to interrogate host‐ Plasmodium interactions instead of studying immune effector mechanisms in isolation. Defining the interactions between immune cells and delineating those that confer protection as opposed to those that interfere will continue to improve our understanding of immune effector mechanisms in malaria and malaria vaccine efficacy.…”

Section: New Areas Of Investigation and New Analytical Approachesmentioning

confidence: 99%

Immune effector mechanisms in malaria: An update focusing on human immunity

Moormann

Nixon

Forconi

2019

Parasite Immunology

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The past decade has witnessed dramatic decreases in malaria‐associated mortality and morbidity around the world. This progress has largely been due to intensified malaria control measures, implementation of rapid diagnostics and establishing a network to anticipate and mitigate antimalarial drug resistance. However, the ultimate tool for malaria prevention is the development and implementation of an effective vaccine. To date, malaria vaccine efforts have focused on determining which of the thousands of antigens expressed by Plasmodium falciparum are instrumental targets of protective immunity. The antigenic variation and antigenic polymorphisms arising in parasite genes under immune selection present a daunting challenge for target antigen selection and prioritization, and is a given caveat when interpreting immune recall responses or results from monovalent vaccine trials. Other immune evasion strategies executed by the parasite highlight the myriad of ways in which it can become a recurrent infection. This review provides an update on immune effector mechanisms in malaria and focuses on our improved ability to interrogate the complexity of human immune system, accelerated by recent methodological advances. Appreciating how the human immune landscape influences the effectiveness and longevity of antimalarial immunity will help explain which conditions are necessary for immune effector mechanisms to prevail.

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“…Plasmodium species are known to cause malaria in vertebrate hosts, which include humans, non-human primates, reptiles, birds, and rodents [ 5 ]. Plasmodium species are categorized into 14 subgenera based on their morphology and host range.…”

Section: Introductionmentioning

confidence: 99%

Zoonotic Malaria: Non-Laverania Plasmodium Biology and Invasion Mechanisms

et al. 2021

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Malaria, which is caused by Plasmodium parasites through Anopheles mosquito transmission, remains one of the most life-threatening diseases affecting hundreds of millions of people worldwide every year. Plasmodium vivax, which accounts for the majority of cases of recurring malaria caused by the Plasmodium (non-Laverania) subgenus, is an ancient and continuing zoonosis originating from monkey hosts probably outside Africa. The emergence of other zoonotic malarias (P. knowlesi, P. cynomolgi, and P. simium) further highlights the seriousness of the disease. The severity of this epidemic disease is dependent on many factors, including the parasite characteristics, host-parasite interactions, and the pathology of the infection. Successful infection depends on the ability of the parasite to invade the host; however, little is known about the parasite invasion biology and mechanisms. The lack of this information adds to the challenges to malaria control and elimination, hence enhancing the potential for continuation of this zoonosis. Here, we review the literature describing the characteristics, distribution, and genome details of the parasites, as well as host specificity, host-parasite interactions, and parasite pathology. This information will provide the basis of a greater understanding of the epidemiology and pathogenesis of malaria to support future development of strategies for the control and prevention of this zoonotic infection.

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Systems Biology-Based Investigation of Host–Plasmodium Interactions

Cited by 21 publications

References 112 publications

Transcriptome analysis of blood and spleen in virulent and avirulent mouse malaria infection

Transcriptome analysis of blood and spleen in virulent and avirulent mouse malaria infection

Immune effector mechanisms in malaria: An update focusing on human immunity

Zoonotic Malaria: Non-Laverania Plasmodium Biology and Invasion Mechanisms

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