Systems based on carbon nanotubes with potential in cancer therapy

Badea, Nicoleta; Craciun, Mariela Madalina; Dragomir, Andreea Sofia; Balaș, Mihaela; Dinischiotu, Anca; Nistor, Claudiu; Găvan, Camelia Stanciu; Ioniță, Daniela

doi:10.1016/j.matchemphys.2019.122435

Cited by 30 publications

(13 citation statements)

References 41 publications

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“…They noted that the mechanism of DOX release was related to Fickian diffusion. The existence of the Fickian diffusion mechanism was also found in the case of drugs release from MWCNTs [ 49 ]. The study of the release mechanism of cytostatic drugs from MWCNTs functionalized by polymers was also carried out [ 50 ].…”

Section: Resultsmentioning

confidence: 99%

Description of Release Process of Doxorubicin from Modified Carbon Nanotubes

Chudoba

Jażdżewska

Łudzik

et al. 2021

IJMS

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The article discusses the release process of doxorubicin hydrochloride (DOX) from multi-wall carbon nanotubes (MWCNTs). The studies described a probable mechanism of release and actions between the surface of functionalized MWCNTs and anticancer drugs. The surface of carbon nanotubes (CNTs) has been modified via treatment in nitric acid to optimize the adsorption and release process. The modification efficiency and physicochemical properties of the MWCNTs+DOX system were analyzed by using SEM, TEM, EDS, FTIR, Raman Spectroscopy and UV-Vis methods. Based on computer simulations at pH 7.4 and the experiment at pH 5.4, the kinetics and the mechanism of DOX release from MWNT were discussed. It has been experimentally observed that the acidic pH (5.4) is appropriate for the efficient release of the drug from CNTs. It was noted that under acidic pH conditions, which is typical for the tumour microenvironment almost 90% of the drug was released in a relatively short time. The kinetics models based on different mathematical functions were used to describe the release mechanism of drugs from MWCNTs. Our studies indicated that the best fit of experimental kinetic curves of release has been observed for the Power-law model and the fitted parameters suggest that the drug release mechanism of DOX from MWCNTs is controlled by Fickian diffusion. Molecular dynamics simulations, on the other hand, have shown that in a neutral pH solution, which is close to the blood pH, the release process does not occur keeping the aggregation level constant. The presented studies have shown that MWCNTs are promising carriers of anticancer drugs that, depending on the surface modification, can exhibit different adsorption mechanisms and release.

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Section: Resultsmentioning

confidence: 99%

Description of Release Process of Doxorubicin from Modified Carbon Nanotubes

Chudoba

Jażdżewska

Łudzik

et al. 2021

IJMS

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“…[105][106][107] In this context, various innovative nanocarriers and nanosystems with targeted and controlled anticancer properties have been designed using CNTs (Tables 3 and 4). 13,104,[108][109][110][111] But, more elaborative studies are still required for ascertaining the biocompatibility, cytotoxicity, carcinogenicity, and pharmacokinetics of these CNT-based nanosystems. 112 Wong et al 113 have reviewed the drug delivery potentials of CNTs, focusing on their drug loading and cellular uptake capacity as well as the other important features; the main challenges for the CNTbased delivery systems are hydrophobicity and potential toxicity (in biological systems).…”

Section: Cnts With Cancer Theranostic Potentialsmentioning

confidence: 99%

Eco-friendly synthesis of carbon nanotubes and their cancer theranostic applications

et al. 2022

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“…Treatment of pancreatic cells PANC-1 with MWCNTs co-loaded with pemetrexed ( Figure 4 ) and quercetin using a dose of 25 μg/mL MWCNTs, 20 μg/mL pemetrexed and 2 μg/mL quercetin caused not only pronounced alterations of cell morphology but also reduced the cell viability (<60%) and resulted in higher intracellular ROS levels compared to treatments with single-nanoDDSs. On the other hand, the cytotoxic effects of single- and double-drug nanoDDSs in MDA-MB-231 breast cancer cells were comparable and less pronounced [ 278 ]. MWCNTs containing iron used as a catalyst during production and MWCNTs from which all iron was removed in a post-production heat treatment (leading to a considerably decreased number of surface defects) caused dose- and time-dependent decrease in the viability of A549 lung epithelial cells and HepG2 hepatocytes and increased lactate dehydrogenase leakage, suggesting a reduced membrane integrity.…”

Section: Carbon Nanotubesmentioning

confidence: 99%

Advances in Drug Delivery Nanosystems Using Graphene-Based Materials and Carbon Nanotubes

Jampílek

Kráľová

2021

Materials

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Carbon is one of the most abundant elements on Earth. In addition to the well-known crystallographic modifications such as graphite and diamond, other allotropic carbon modifications such as graphene-based nanomaterials and carbon nanotubes have recently come to the fore. These carbon nanomaterials can be designed to help deliver or target drugs more efficiently and to innovate therapeutic approaches, especially for cancer treatment, but also for the development of new diagnostic agents for malignancies and are expected to help combine molecular imaging for diagnosis with therapies. This paper summarizes the latest designed drug delivery nanosystems based on graphene, graphene quantum dots, graphene oxide, reduced graphene oxide and carbon nanotubes, mainly for anticancer therapy.

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Systems based on carbon nanotubes with potential in cancer therapy

Cited by 30 publications

References 41 publications

Description of Release Process of Doxorubicin from Modified Carbon Nanotubes

Description of Release Process of Doxorubicin from Modified Carbon Nanotubes

Eco-friendly synthesis of carbon nanotubes and their cancer theranostic applications

Advances in Drug Delivery Nanosystems Using Graphene-Based Materials and Carbon Nanotubes

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