Systemic use of pentosan polysulphate in the treatment of osteoarthritis

Abstract

Forty dogs diagnosed as having chronic osteoarthritis took part in a double-blind clinical dose-response study using the antiarthritic agent pentosan polysulphate (PPS). After complete physical examination to ensure good general health, dogs received four subcutaneous injections at intervals of one week 0, 1, 3 or 5 mg/kg PPS from code-numbered bottles. At weekly intervals and four weeks after the last injection, weakness, stiffness, pain on joint manipulation, willingness to exercise, body condition and overall response were scored. There were no differences between groups in baseline data, but dogs receiving PPS had a favourable response compared to dogs receiving a placebo for lameness, body condition, pain on joint manipulation and willingness to exercise. The 3 mg/kg dose rate gave the best improvement, the 1 mg/kg dose was partially effective and the 5 mg/kg group was least effective. The use of PPS at a dose rate of 3 mg/kg for the treatment of clinical osteoarthritis in dogs is indicated by our study.

Systematic review of the management of canine osteoarthritis

“…Pharmacological agents There were 40 studies of pharmacological agents as symptom-modifying agents, structure-modifying agents, or both (Altman and others 1989a, b, Howell and others 1991, Myers and others 1991, 1999, Rogachefsky and others 1993, Fernandes and others 1995, 1998, Vasseur and others 1995, Carney 1996, Read and others 1996, Yu and others 1996, Jovanovic and others 1997, Budsberg and others 1999, 2007, Manicourt and others 1999, Pelletier and others 1999, 2005, Smith and others 1999, Doig and others 2000, Innes and others 2000, Boileau and others 2002, Lipscomb and others 2002, Nell and others 2002, Hazewinkel and others 2003, Moreau and others 2003, 2006, 2007, Behets and others 2004, El Hajjaji and others 2004, Lajeunesse and others 2004, Pardy and others 2004, Peterson and Keefe 2004, Hanson and others 2006, Karsdal and others 2006, Mastbergen and others 2006, Pollmeier and others 2006, Ryan and others 2006, Brainard and others 2007, Mansa and others 2007). …”

Subtotal Coronoid Ostectomy for Treatment of Medial Coronoid Disease in 263 Dogs

“…The administration of a course of 4 injections of pentosan polysulfate during the immediate postoperative period may have contributed to clinical improvement 27 seen during this phase of recovery, but was considered unlikely to have had any sustained confounding effect on long-term outcome. The postoperative management approach we used dictated that the earliest possible return to ''normal function'' was 12 weeks because off leash exercise was not permitted before then.…”

Xylans of Industrial and Biomedical Importance

“…PPS was shown to be an anti-arthritic agent for dogs having chronic osteoarthritis (Rogachefsky et lIl., 1994;Read et a/., 1996). Due to the relatively high molecular weight, the ability of PPS to enter connective tissues rich in proteoglycans and interact with the resident cells has been questioned.…”