Systemic toxicity eliciting metal ion levels from metallic implants and orthopedic devices – A mini review

Badhe, Ravindra V.; Akinfosile, Obakanyin J.; Bijukumar, Divya; Barba, Mark; Mathew, Mathew T.

doi:10.1016/j.toxlet.2021.07.004

Cited by 44 publications

(20 citation statements)

References 138 publications

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“…Compared with the working concentrations of reported metal nanoparticles, recently reported ultrasmall copper oxide [13] and manganese dioxide nanoparticles [30] might manifest better catalytic e ciency than Ta-NH 2 NPs. However, these metal nanomaterials might be ionized by body uid [15] to generate free metal ions, which further led to element imbalance or even metal poisoning [16,17]. In addition, compared with inert metal such as cerium and gold nanoparticles [31], Ta-NH 2 NPs showed stronger H 2 O 2 decomposition.…”

Section: Resultsmentioning

confidence: 99%

“…These reactive metal-based nanomaterials have displayed good bioavailability and excellent therapeutic e ciency at very low concentration (≈ nM/mL) to treat oxidative stress-related diseases in animal model. However, the potential disadvantages such as ionization in body uid [15] and uncertainty of long-term metal cumulation [16,17] still impede its clinical application.…”

Section: Introductionmentioning

confidence: 99%

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Biocompatible Amino-modificated Tantalum Nanoparticles with Catalase Activity for Sustained Intra-articular Reactive Oxygen Species Scavenging and Alleviation of MIA induced Osteoarthritis

Jiang

Yang

et al. 2022

Preprint

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Background Osteoarthritis (OA), which involves the dysfunction of articular cartilage, is the most common form of joint disease that results in arthralgia, joint deformation and limited mobility in patients. Recent studies highlighted the vital role of oxidative stress and reactive oxygen species (ROS) during progression of OA. Therefore, attenuating oxidative stress and reducing ROS generation in articular joints represent reasonable strategies for the treatment of OA. However, in addition to instability of current antioxidants caused by fluctuation in osteoarthritic physicochemical microenvironment, poor biocompatibility and short articular joint retention also seriously hindered their clinical application. Results Considering the above-mentioned, the present study provided high biocompatible small positively charged tantalum nanoparticles (Ta-NH2 NPs) with sustained intra-articular catalase activity. Our in vitro results showed that Ta-NH2 NPs had good biocompatibility and stability, and could protect viability and hyaline-like phenotype in chondrocyte under H2O2 challenge. In addition, the in vivo biodistribution data demonstrated sustained retention of Ta-NH2 NPs in the joint cavity, particularly in articular cartilage with unnoticed organ toxicity and abnormity in hemogram and blood biochemistry analyses. Finally, compared with catalase (CAT), Ta-NH2 NPs exhibited long-term therapeutic effect in monosodium iodoacetate (MIA) induced OA model. Conclusion This study explored the potential of Ta-NH2 NPs as effective ROS scavenging agent for intra-articular injection, and offered a novel strategy to achieve sustained ROS suppression using biocompatible Ta-based nano-medicine in oxidative stress related diseases.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Biocompatible Amino-modificated Tantalum Nanoparticles with Catalase Activity for Sustained Intra-articular Reactive Oxygen Species Scavenging and Alleviation of MIA induced Osteoarthritis

Jiang

Yang

et al. 2022

Preprint

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“…In the following section, we will evaluate the existing antimicrobial nanotechnologies with respect to their potential pathways leading to antimicrobial resistance. We also refer readers to more comprehensive reviews that focus more on the antimicrobial mechanisms and toxicological aspects of various nanotechnologies [ [135] , [136] , [137] ].…”

Section: Microbial Resistance To Nanotechnologiesmentioning

confidence: 99%

Microbial resistance to nanotechnologies: An important but understudied consideration using antimicrobial nanotechnologies in orthopaedic implants

Chan

Low

et al. 2022

Bioactive Materials

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“…Therapeutic approaches for bone fracture fixation and stabilization commonly rely on the use of non-degradable biomaterials with adequate mechanical properties and biocompatibility—namely metallic implants based on stainless steel, titanium, and cobalt-chromium alloys—that present a high corrosion resistance and are able to maintain long-term structural stability of the tissues [ 1 , 2 ]. Despite the overall adequacy, some biological limitations have been reported with long-term use, including physical irritation, chronic immuno-inflammatory activation, and the release of cytotoxic elements that may hinder biological responses and entail a second surgical procedure for implant removal, increasing morbidity, hospitalization time, and consequently healthcare costs [ 3 , 4 , 5 ]. Further, elastic modulus differences between non-resorbable metallic implants and bone tissue may induce stress shielding that can interfere with bone turnover exceling bone loss, ultimately leading to fixation deterioration that culminates with the need of a revision surgery [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Simulating In Vitro the Bone Healing Potential of a Degradable and Tailored Multifunctional Mg-Based Alloy Platform

et al. 2022

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This work intended to elucidate, in an in vitro approach, the cellular and molecular mechanisms occurring during the bone healing process, upon implantation of a tailored degradable multifunctional Mg-based alloy. This was prepared by a conjoining anodization of the bare alloy (AZ31) followed by the deposition of a polymeric coating functionalized with hydroxyapatite. Human endothelial cells and osteoblastic and osteoclastic differentiating cells were exposed to the extracts from the multifunctional platform (having a low degradation rate), as well as the underlying anodized and original AZ31 alloy (with higher degradation rates). Extracts from the multifunctional coated alloy did not affect cellular behavior, although a small inductive effect was observed in the proliferation and gene expression of endothelial and osteoblastic cells. Extracts from the higher degradable anodized and original alloys induced the expression of some endothelial genes and, also, ALP and TRAP activities, further increasing the expression of some early differentiation osteoblastic and osteoclastic genes. The integration of these results in a translational approach suggests that, following the implantation of a tailored degradable Mg-based material, the absence of initial deleterious effects would favor the early stages of bone repair and, subsequently, the on-going degradation of the coating and the subjacent alloy would increase bone metabolism dynamics favoring a faster bone formation and remodeling process and enhancing bone healing.

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Systemic toxicity eliciting metal ion levels from metallic implants and orthopedic devices – A mini review

Cited by 44 publications

References 138 publications

Biocompatible Amino-modificated Tantalum Nanoparticles with Catalase Activity for Sustained Intra-articular Reactive Oxygen Species Scavenging and Alleviation of MIA induced Osteoarthritis

Biocompatible Amino-modificated Tantalum Nanoparticles with Catalase Activity for Sustained Intra-articular Reactive Oxygen Species Scavenging and Alleviation of MIA induced Osteoarthritis

Microbial resistance to nanotechnologies: An important but understudied consideration using antimicrobial nanotechnologies in orthopaedic implants

Simulating In Vitro the Bone Healing Potential of a Degradable and Tailored Multifunctional Mg-Based Alloy Platform

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