Systemic sclerosis induced by the use of cocaine: is there an association?

Andreussi, R.P.; Silva, Lila Morena Bueno da; Silva, Henrique Carriço da; Assad, Ana Paula Luppino; Andrade, Danieli; Sampaio-Barros, Percival D.

doi:10.1007/s00296-018-4227-6

Cited by 12 publications

(1 citation statement)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Only 10 cases of cocaine-induced/-exacerbated SSc have been reported. [84][85][86][87][88][89][90] Common SSc features in these patients included marked vascular complications that manifest after 2-5 years of cocaine intake (eg, digital ulceration and renal crisis). 90 Awaiting further confirmation, it remains plausible that regular cocaine use may worsen vascular features of SSc due to its inherent vasoconstrictive properties.…”

Section: Cocainementioning

confidence: 99%

Toward Understanding of Environmental Risk Factors in Systemic Sclerosis

et al. 2020

View full text Add to dashboard Cite

Importance Systemic sclerosis (SSc) is a severe, chronic, and incurable autoimmune fibrotic skin disease with significant extracutaneous involvement. Low concordance rate in twin studies and unequal geographic distribution of SSc argues for importance of environment in disease initiation and progression. Objective In this manuscript we provide a summary of all investigated potential external risk factors for SSc. Data sources A literature search in PubMed and EMBASE database was performed for studies published until January 1, 2020 by 2 reviewers (EN and LO) independently. Findings Occupational and/or environmental exposures to silica and organic solvents are associated with increased incidence and severity of SSc. Exposure to epoxy resins, asbestos, and particulate air pollution favors increased risk of SSc, but data are based on limited number of observational studies. There is insufficient evidence to conclude an association between SSc development and other occupational (eg, welding fumes) or personal exposures (eg, smoking, vitamin D deficiency). Association of SSc with silicone breast implants has been disproven. Infectious pathogens (eg, Helicobacter pylori and angiotropic viruses) and dysbiosis seem to play a role in SSc development and severity, but their role remains to be clarified. Conclusions and relevance It may be prudent to counsel our patients with SSc (or those at risk of SSc) to avoid occupations with exposure to silica, organic solvents, asbestos and epoxy resins; restraint from smoking, using cocaine or drugs with pro-fibrotic potential. While the association between low vitamin D and SSc remains to be confirmed, we believe that SSc patients should be encouraged to maintain healthy vitamin D levels as benefits outweigh the risks.

show abstract

Section: Cocainementioning

confidence: 99%

Toward Understanding of Environmental Risk Factors in Systemic Sclerosis

et al. 2020

View full text Add to dashboard Cite

show abstract

Acquired Disorders of Dermal Connective Tissue

Fahy,

Lovell

2024

Rook's Textbook of Dermatology

View full text Add to dashboard Cite

This chapter reviews acquired changes in dermal connective tissue during normal ageing and in disease processes, including photodamage. Corticosteroids are a potent cause of dermal atrophy, which may also be congenital or induced by inflammatory disorders related to morphoea. Enzymatic degradation of elastic tissue results in localised or generalised skin laxity, which resembles genetic disorders such as pseudoxanthoma elasticum and cutis laxa. In contrast, some disorders are characterised by excessive deposition of collagen or elastic tissue. Fibrosis is associated with contracture, which causes deformity and restricted movement as in palmoplantar fibromatosis. Several chemical environmental triggers induce diffuse fibrosis resembling systemic sclerosis. Keloids represent an abnormal scarring response to trauma. Finally, dermal connective tissue components may be extruded via the epidermis in perforating disorders such as elastosis perforans serpiginosa.

show abstract