Systemic sclerosis and scleroderma renal crisis in association with carcinoma of the breast

Scleroderma renal crisis in a patient with paraneoplastic systemic sclerosis

“…Interestingly, TGF-β is elevated in several malignancies, notably breast, renal, and ovarian cancers. 1 Many chemotherapies also contribute to SS, such as paclitaxel, docetaxel, and bleomycin. 1…”

“…4 Few cases of pSS have been described, and its pathogenesis is linked to the development of cancer-induced autoimmunity. 1,2 Cancer cells may produce biologically active cytokines and growth factors that are considered profibrotic, such as transforming growth factor-β (TGFβ). Interestingly, TGF-β is elevated in several malignancies, notably breast, renal, and ovarian cancers.…”

“…Interestingly, TGF-β is elevated in several malignancies, notably breast, renal, and ovarian cancers. 1 Many chemotherapies also contribute to SS, such as paclitaxel, docetaxel, and bleomycin. 1 The clinical and laboratory findings in patients with pSS are similar to those in patients with idiopathic SS, but the following characteristics deserve attention in pSS: close temporal association between the SS symptoms and the cancer diagnosis; prompt response to chemotherapy; and recurrence with cancer relapses.…”

“…The most frequent cancers related to this disease are breast cancer and pulmonary carcinoma, but a wide range of malignancies have been reported. 1 Nevertheless, only a few cases of paraneoplastic systemic sclerosis (pSS) have been described. 2 Scleroderma renal crisis is an uncommon but severe complication of SS, with acute kidney failure, abrupt onset of hypertension and microangiopathy.…”

Coxitis as a Manifestation of Paraneoplastic Syndrome

“…Это дерматомиозит [3], сис-темные васкулиты [4], ревматическая поли-миалгия [5], псевдосклеродермические син-дромы [6]. Среди ревматических проявле-ний ПНС наиболее часто наблюдается сус-тавной синдром.…”