Systemic right ventricular longitudinal strain is reduced in adults with transposition of the great arteries, relates to subpulmonary ventricular function, and predicts adverse clinical outcome

Diller, Gerhard‐Paul; Radojevic, Jelena; Kempny, Aleksander; Alonso‐Gonzalez, Rafael; Liodakis, Emmanouil; Orwat, Stefan; Swan, Lorna; Uebing, Anselm; Li, Wei; Dimopoulos, Konstantinos; Gatzoulis, Michael Α.; Baumgartner, Helmut

doi:10.1016/j.ahj.2012.01.038

Cited by 100 publications

(65 citation statements)

References 27 publications

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“…This finding is of clinical importance, considering the papers by Kalogeropoulos et al [16] and Diller et al [17], which reported that reduced global longitudinal strain is associated with a higher risk of adverse clinical events (progression to NYHA class ≥ 3, clinically relevant cardiac arrhythmia, or death) in patients with subaortic RV. In the present study, BMI correlated weakly with the global longitudinal strain values.…”

Section: Discussionmentioning

confidence: 90%

Assessment of systemic right ventricular function in adult overweight and obese patients with congenitally corrected transposition of the great arteries

Kowalik¹,

Klisiewicz²,

Biernacka³

et al. 2017

Kardiol Pol

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A b s t r a c t Background:In congenitally corrected transposition of the great arteries the right ventricle (RV) supports systemic circulation, and patients are prone to develop heart failure over time. Chronic volume overload secondary to obesity may contribute to premature dysfunction of the systemic RV. Aim:The aim of our study was to assess the systemic RV function in overweight/obese adult patients with congenitally corrected transposition of the great arteries. Methods:Transthoracic echocardiographic studies and laboratory testing (N-terminal pro-B-type natriuretic peptide [NT-proBNP] assessment) were performed in patients with congenitally corrected transposition, who were scheduled for a routine examination, and the body mass index was calculated for each patient. Results:We studied 56 adults (31 men; mean age 33.9 years); 22 of whom were overweight (body mass index [BMI] of 25-29.9 kg/m 2 ) or obese (BMI of 30 kg/m 2 or more), and 34 of whom were normal weight (BMI below 25 kg/m 2 ). Age, gender, heart rate, and blood pressure were similar in both groups. The mean NT-proBNP levels were not significantly different. On echocardiography, the overweight/obese patients had a decreased systemic RV fractional area change (0.38) compared to normal weight patients (0.43); p = 0.02. Moreover, a significant reduction in the global longitudinal strain in the overweight/obese group was observed (-15.3% vs. -18.3%; p = 0.01).Conclusions: Overweight/obesity in adult patients with congenitally corrected transposition of the great arteries is associated with impaired systemic RV function.

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Section: Discussionmentioning

confidence: 90%

Assessment of systemic right ventricular function in adult overweight and obese patients with congenitally corrected transposition of the great arteries

Kowalik¹,

Klisiewicz²,

Biernacka³

et al. 2017

Kardiol Pol

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“…However, the systemic two-dimensional longitudinal strain was significantly reduced in the patients with a systemic RV and was related to a worse clinical outcome in the setting of an atrial switch transposition of the great arteries [8]. Furthermore, the systemic and subpulmonary myocardial function appears to be interrelated in patients with a systemic RV, possibly because of an adverse ventriculo-ventricular interaction [8,9].…”

Section: Discussionmentioning

confidence: 97%

“…First, the electrical conduction was not delayed within the RV; however, the ECG exhibited a wide QRS duration with an RBBB pattern. Second, the pulmonary stenosis was present, which reportedly causes the interaction between the systemic and subpulmonary ventricular function to become more pronounced in patients with a systemic RV and pulmonary stenosis [8]. To the best of our knowledge, there has been only one case report that has discussed the interventricular dyssynchrony in a patient with a biventricular physiology and systemic RV [12].…”

Section: Discussionmentioning

confidence: 98%

“…The function of the systemic RV and subpulmonary LV has also been reported to be interrelated in the patients with a transposition of the great arteries (TGA) after an atrial switch operation and congenitally corrected TGA [8,9]. The interventricular dyssynchrony in the systemic RV can cause the systemic RV function to deteriorate, because the interventricular septum belongs to both ventricles and some degree of RV contraction relies on the LV contraction.…”

Section: Introductionmentioning

confidence: 97%

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Interventricular dyssynchrony in a patient with a biventricular physiology and a systemic right ventricle

et al. 2016

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We describe of a unique pattern of cardiac dyssynchrony in a patient with a biventricular physiology and systemic right ventricle (RV): the interventricular dyssynchrony due to a contraction delay between the left ventricle and RV. In the present case, the cineangiography and intracardiac electrocardiography of the RV did not reveal intraventricular dyssynchrony of the RV, but revealed interventricular dyssynchrony. In addition, the pressure curves of the ventricles exhibited time phase differences between the two ventricles. The cardiac resynchronization therapy determining the pacing lead positions based on the idea of interventricular dyssynchrony induced reverse cardiac remodeling in this patient with systemic RV dysfunction.

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“…Moreover, it has been recently reported that global longitudinal systolic strain is significantly reduced in patients with a systemic RV. (19) Global longitudinal strain also relates to subpulmonary ventricular function and predicts adverse clinical outcome in adults with atrial switch for TGA. (19) In patients with CHD, real-time 3D echocardiography is an accurate and reproducible technique to visualise the cardiac and valve Another of CMR's strengths is its ability to assess vascular stenoses.…”

Section: Echocardiographymentioning

confidence: 99%

Non-invasive imaging in congenital heart disease

Alonso‐Gonzalez

Swan

2017

SAHJ

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Systemic right ventricular longitudinal strain is reduced in adults with transposition of the great arteries, relates to subpulmonary ventricular function, and predicts adverse clinical outcome

Cited by 100 publications

References 27 publications

Assessment of systemic right ventricular function in adult overweight and obese patients with congenitally corrected transposition of the great arteries

Assessment of systemic right ventricular function in adult overweight and obese patients with congenitally corrected transposition of the great arteries

Interventricular dyssynchrony in a patient with a biventricular physiology and a systemic right ventricle

Non-invasive imaging in congenital heart disease

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