Systemic Review of Ocimum sanctum (Tulsi): Morphological Characteristics, Phytoconstituents and Therapeutic Applications

Many people suffer from ulcer, a disorder of the digestive tract. Simply put, it's an inflamed break in the skin or the mucus membrane lining the digestive tract. Whenever there is a change in the equilibrium, such as increased aggression or decreased mucosal resistance, ulceration develops. Reasons for this could include drug use, poor diet, stress, and other similar factors. Peptic ulcers are a general term for any type of stomach or duodenal ulcer. To develop, peptic ulcers need mucosal defences to be compromised in addition to gastric juice acid and peptic activity. Ulcers can be treated with a variety of synthetic medications. However, compared to herbal remedies, these drugs are more costly and more likely to cause side effects. According to the research, many different ayurvedic doctors and traditional medicine practitioners use different medicinal plants and polyherbal formulations to treat ulcers. Peptic ulcer disease treatment should focus on symptom alleviation, ulcer healing, and preventing recurrence. In this article, we'll take a look at some medicinal plants that have been studied for their potential use in peptic ulcer treatment and prevention, both in ayurveda and Western medicine.

Section: Bauhinia Variegatementioning

confidence: 89%

A Study of Various Medicinal Plants used in Ulcer Treatment: A Review

Awuchi

Saha

Amle

et al. 2023

“…Mental health conditions like depression, anxiety, and post-traumatic stress disorder are all closely related to insomnia. [8][9][10][11][12] RLS, persistent pain, GERD, respiratory issues, and inactivity are all medical disorders that raise the risk of developing chronic insomnia. Problems with development can be linked to a child's susceptibility to developing sleep disorders.…”

Section: Etiologymentioning

confidence: 99%

“…Nowadays, getting a decent night's sleep is regarded as essential for cardiovascular health [9]. Patients with persistent insomnia are more likely to have cardiovascular disease, diabetes, arterial hypertension, depression, anxiety, and decreased cognitive function [8,10,11,12]. As a result, chronic insomnia has a high financial impact on both individuals and healthcare systems [2,13].…”

Section: Introductionmentioning

confidence: 99%

Plants Alkaloids Based Compound as Therapeutic Potential for Neurodegenerative

Patel¹,

Gangwar²,

Gupta³

et al. 2023

Although while getting a restful night's sleep is essential for your mental and physical health, insomnia is very prevalent. More people are turning to complementary and alternative therapies to treat or prevent sleeplessness. For hundreds of years, herbal treatments like valerian, passionflower, lemon balm, lavender, and California poppy have been utilized successfully. After using these herbal medicines, sleep latency was reduced and subjective and objective measures of sleep quality improved. Their sedative and sleep-inducing effects are caused by interactions with several neurotransmitter systems in the brain, according to molecular research. The plant species can be divided into 76 different genera and 32 different families, with the Asteraceae (24.2%) and Lamiaceae (21.1%) being the most prevalent subgroups. Leaves (29%) and flowers (27%), respectively, are used to make the majority of infusions (70%) and decoctions (25%). Just the most well-known taxa—out of the 106 known—are treated here (A. arvensis L., C. nepeta L., C. monogyna Jacq., H. lupulus L., L. nobilis L., L. angustifolia Mill., M. sylvestris L., M. chamomilla L., M. officinalis L., O. basilicum L., P. rhoeas L., P. somniferum L., R. officinalis L., T. platyphyllus Scop., and V. officinalis L.). Further study is required to confirm the therapeutic potential of these substitutes and define the mechanism of action of bioactive compounds because only seven of the fifteen species chosen have been investigated for pharmacological activity as hypnotic-sedatives.

“…In order to propel the contents of the perivascular space forward, the perivascular pump mechanism relies on systolic arterial pressure waves propagating through the vessels [95]. Ethmoidal arteries, which originate in the ophthalmic and internal carotid arteries, provide an abundant blood supply to the nose [8]. Substances can enter the central nervous system via the perivascular areas surrounding these arteries [5,11].Studies comparing intranasal and arterial administration in animals have shown that substances administered in the former route enter the cerebral perivascular spaces within 20 minutes [16], are found in greater concentrations in the dura mater and circle of Willis [17], and are found in greater concentrations in the deep and superficial cervical nodes of rats [95], indicating that they may be transported via lymphatic drainage from the nasal passages and CSF.…”

Section: Intranasal Administration As An Alternative To the Oral Rout...mentioning

confidence: 99%

“…Class II medications are poorly soluble in water but highly permeable at therapeutic levels, while class IV pharmaceuticals are poorly soluble in water and poorly permeable. This can reduce the drug's bioavailability and delay the beginning of its effects [8,9]. It can also reduce the drug's solubility, absorption rate, and extension.…”

Section: Introductionmentioning

confidence: 99%

Recent Advancement in Self Emulsifing Drug Delivery System

Bist

Faruk

2023

Every day, researchers make new attempts to identify neurotherapeutics, but few of them make it to clinical trials. The main cause is their low bioavailability, which is connected to low water solubility, low permeability through biological membranes, and the hepatic first-pass metabolism. However, the most significant challenge in administering drugs to the brain is overcoming the blood-brain barrier. In order to get around it, intranasal administration has become more popular, sometimes even more so than oral administration. Because of its structure, the nasal cavity can bypass the blood-brain barrier and transport drugs to the brain directly. Nasal absorption increases the systemic bioavailability of highly processed substances because they bypass the hepatic first-pass metabolism. However, due to their unique physicochemical properties, most neurotherapeutics must be synthesized in lipidic nanosystems as self-emulsifying drug delivery systems (SEDDS). To load large quantities of lipophilic medicines into micro or nanoemulsions, these isotropic mixes of oils, surfactants, and co-surfactants are diluted in water. The goal of SEDDS is to increase the stability of labile pharmaceuticals against enzymatic activity, boost drug penetration through absorptive membranes, and reduce the likelihood of drug precipitation at absorption sites. Therefore, improved brain targeting and bioavailability of medications might be anticipated by combining the benefits of SEDDS with those of the intranasal route for brain delivery. In order to better understand the mechanisms involved in the intranasal administration of pharmaceuticals loaded in SEDDS, this paper provides a comprehensive characterization of SEDDS as a lipidic nanosystem. Finally, the in vivo effects of intranasal or oral delivery of SEDDS, showing their superiority over standard solutions or suspensions, are described.