Systemic, pulmonary, and hepatosplanchnic effects of N-acetylcysteine during long-term porcine endotoxemia*

Vassilev, Damian; Hauser, Balázs; Bracht, Hendrik; Iványi, Zsolt; Schoaff, M.; Asfar, Pierre; Vogt, J.; Wachter, Ulrich; Schelzig, Hubert; Georgieff, Michael; Brückner, U. B.; Radermacher, Peter; Fröba, Gebhard

doi:10.1097/01.ccm.0000110679.52670.c4

Cited by 37 publications

(31 citation statements)

References 47 publications

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“…In the present study, systemic vascular resistance showed no signifi cant changes, and CO was steadily reduced during LPS infusion (hypodynamic circulation). Despite the differences between human and porcine hemodynamic response patterns, the porcine model of septic shock has been widely used in cardiovascular research and to examine the pathophysiology of multiple organ dysfunction/ failure [29][30][31]. The use of large animals has several advantages compared with shock models in small animals, including mice, rats, and rabbits.…”

Section: Discussionmentioning

confidence: 99%

Systematic evaluation of nitric oxide, tetrahydrobiopterin, and anandamide levels in a porcine model of endotoxemia

et al. 2008

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Section: Discussionmentioning

confidence: 99%

Systematic evaluation of nitric oxide, tetrahydrobiopterin, and anandamide levels in a porcine model of endotoxemia

et al. 2008

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“…In the experimental study of Vassilev et al, [14] they investigated the effects of NAC on gas exchange and metabolism in the systemic, pulmonary and hepatosplanchnic areas in endotoxemia, which is a condition similar to sepsis in humans. In that study, NAC treatment was found to increase the GSH concentration.…”

Section: Discussionmentioning

confidence: 99%

The effect of N-acetyl cysteine on serum glutathione, TNF-α and tissue malondialdehyde levels in the treatment of sepsis

Gül¹,

Ayan²,

Seydanoğlu³

et al. 2011

Ulus Travma Acil Cerrahi Derg

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“…yapt›klar› deneysel çal›flmada, insanlarda sepsis tablosuna benzeyen bir durum olan endotoksemide NAC'›n sistemik, pulmoner, ve hepatosplaknik alanda gaz de¤iflimi ve metabolizmaya etkilerini araflt›rd›. Çal›flma sonucunda NAC tedavisinin GSH konsantrasyonunda art›fla sebep oldu¤u bulundu (18) . Çal›flmam›zdaki veriler incelendi¤inde; sadece sepsis grubunda oksidatif strese ba¤l› olarak eritrosit GSH de¤erinde azalma oldu¤u görüldü.…”

Section: Histopatolojik Bulgularunclassified

Deneysel Sepsis Modelinde Glutatyon, Myeloperoksidaz, Plazma Ve Doku Mda Düzeylerine N-Asetilsistein Ve Erdostein’in Etkilerinin Karşılaştırılması

Ayan¹

2009

jaem

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SUMMARY Objectives:To determine the effects of NAC and erdostein as antioxidant agents on the free oxygen radicals and on their plasma levels. The role of NAC and erdostein on protecting the organ function failure and lung tissue damage due to sepsis was researched. Methods: In this study, 40 Sprague-Dawley rats were used. Rats were randomized to four equal groups. Sepsis was performed by the method of Caecum Ligation Perforation (CLP) on rats. Four groups were performed as sham group, sepsis group, sepsis+NAC (20mg/kg/day) and sepsis + erdostein (20mg/kg/day) NAC was given on 0. , 8. and 16.hours after CLP in NAC group. Erdostein was given on 0. and 12.hours after CLP. Blood samples were taken after 24 hours to determine the leukocyte, erythrocyte GSH, leukocyte MPO and plasma MDA levels. In addition, lung tissue samples were taken for histopathological studies and to determine the level of tissue MDA. Results: Comparing of groups on the level of leukocyte, leukocyte MPO and lung tissue MDA we determined statistically meaningful results in group 3 according to the group 2. But there were no meaningful differences on erythrocyte GSH and plasma MDA in group3 according to group 2(P>0.05). Comparing of groups on the level of erythrocyte GSH, leukocyte MPO plasma MDA and lung tissue MDA we determined statistically meaningful results in group 4 according to the group 2(P<0.05). But there were no meaningful differences on leukocyte in group 4 according to group 2(P>0.05). Conclusion:In this experimental sepsis model; it was determined that low dose NAC and erdostein as antioxidant agents have positive effects on erythrocyte GSH, leukocyte MPO, plasma and tissue MDA levels and the function of lung. Although the treatment with low dose NAC and erdostein has decreased the abnormality of organ function due to sepsis we couldn't show it histopathologically. We need more experimental studies to determine the effects of NAC and erdostein on sepsis therapy. ÖZET Amaç: Deneysel sepsis modelinde antioksidan bir ajan olan N-asetilsistein ve Erdostein'in serbest oksijen radikalleri üzerine olan etkileri ve sepsisin neden oldu¤u organ fonksiyon bozukluklar› ve akci¤er doku hasar›n› önlemedeki rolü araflt›r›ld›. Metod: Çal›flmada Sprague-Dawley cinsi 40 adet rat kullan›ld›. Ratlar randomize 10'arl› gruplara ayr›ld›lar. Ratlarda çekum ligasyon perforasyon yöntemiyle sepsis oluflturuldu. Sham grubu (grup 1), sepsis grubu (grup 2), sepsis + N-asetisistein (grup 3) ve sepsis + Erdostein (grup 4) fleklinde 4 grup oluflturuldu. N-asetilsistein grubunda ilaçlar (20mg/kg/gün), çekum perforasyonundan sonra, 0. 8. ve 16. saatlerde verildi. Erdostein grubunda ise ilaçlar(20mg/kg/gün) 0.ve 12. saatlerde verildi. 24. saatte lökosit, eritrosit glutatyon, lökosit myeloperoksidaz ve plazma malonildialdehit de¤erlerinin tayini için kan örnekleri ve doku incelemeleri için deneklerin ölümünü takiben akci¤erden doku örnekleri al›nd›. Bulgular: Gruplar karfl›laflt›r›ld›¤›nda grup 3'te grup 2'ye göre; lökosit, lökosit myeloperoksidaz ve akci¤er doku mal...

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Systemic, pulmonary, and hepatosplanchnic effects of N-acetylcysteine during long-term porcine endotoxemia*

Cited by 37 publications

References 47 publications

Systematic evaluation of nitric oxide, tetrahydrobiopterin, and anandamide levels in a porcine model of endotoxemia

Systematic evaluation of nitric oxide, tetrahydrobiopterin, and anandamide levels in a porcine model of endotoxemia

The effect of N-acetyl cysteine on serum glutathione, TNF-α and tissue malondialdehyde levels in the treatment of sepsis

Deneysel Sepsis Modelinde Glutatyon, Myeloperoksidaz, Plazma Ve Doku Mda Düzeylerine N-Asetilsistein Ve Erdostein’in Etkilerinin Karşılaştırılması

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