Systemic physiology augmented functional near-infrared spectroscopy: a powerful approach to study the embodied human brain

Scholkmann, Felix; Tachtsidis, Ilias; Wolf, Martin; Wolf, Ursula

doi:10.1117/1.nph.9.3.030801

Cited by 31 publications

(41 citation statements)

References 138 publications

(274 reference statements)

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“…Systemic physiology augmented functional near-infrared spectroscopy (SPA-fNIRS) is a method that enables the measurement and analysis of fNIRS neuroimaging data along with data from systemic physiology. SPA-fNIRS is expected to be an excellent approach to study brain-body interaction using systemic physiological signal data (Scholkmann et al, 2022a ).…”

Section: Discussionmentioning

confidence: 99%

Frontal lobe hemodynamics detected by functional near-infrared spectroscopy during head-up tilt table tests in patients with electrical burns

Kim

Kim²,

Yoon

et al. 2022

Front. Hum. Neurosci.

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SignificanceElectrical burns can cause severe damage to the nervous system, resulting in autonomic dysfunction with reduced cerebral perfusion. However, few studies have investigated these consequences.AimTo elucidate changes in prefrontal cerebral hemodynamics using functional near-infrared spectroscopy (fNIRS) during the head-up tilt table test (HUT) for patients with electrical burns.ApproachWe recruited 17 patients with acute electrical burns within 1 week after their accidents and 10 healthy volunteers. The NIRS parameters acquired using an fNIRS device attached to the forehead were analyzed in five distinct HUT phases.ResultsBased on their HUT response patterns, patients with electrical burns were classified into the group with abnormal HUT results (APG, n = 4) or normal HUT results (NPG, n = 13) and compared with the healthy control (HC, n = 10) participants. We found trends in hemodynamic changes during the HUT that distinguished HC, NPG, and APG. Reduced cerebral perfusion and decreased blood oxygenation during the HUT were found in both the NPG and APG groups. Patients with electrical burns had autonomic dysfunction compared to the HC participants.ConclusionsUsing fNIRS, we observed that acute-stage electrical burn injuries could affect cerebral perfusion.

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Section: Discussionmentioning

confidence: 99%

Frontal lobe hemodynamics detected by functional near-infrared spectroscopy during head-up tilt table tests in patients with electrical burns

Kim

Kim²,

Yoon

et al. 2022

Front. Hum. Neurosci.

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“…Confounding factors for brain oxygenation changes assessed by NIRS during hyperventilation test are the local neuronal activity and the neurovascular coupling reflex, vasomotricity of brain vessels in response to mean arterial pressure changes, muscle activity, and autonomic nervous system activation [ 31 ]. Recently, all these physiological systemic parameters have gained attention for fNIRS neuroimaging analysis, and a new method was developed, the systemic physiology augmented functional near-infrared spectroscopy (SPA-fNIRS), which allows a more comprehensive interpretation of the brain fNIRS signals [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Near-Infrared Spectroscopy Usefulness in Validation of Hyperventilation Test

et al. 2022

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Background: The hyperventilation test is used in clinical practice for diagnosis and therapeutic purposes; however, in the absence of a standardized protocol, the procedure varies significantly, predisposing tested subjects to risks such as cerebral hypoxia and ischemia. Near-infrared spectroscopy (NIRS), a noninvasive technique performed for cerebral oximetry monitoring, was used in the present study to identify the minimum decrease in the end-tidal CO2 (ETCO2) during hyperventilation necessary to induce changes on NIRS. Materials and Methods: We recruited 46 volunteers with no preexisting medical conditions. Each subject was asked to breathe at a baseline rate (8–14 breaths/min) for 2 min and then to hyperventilate at a double respiratory rate for the next 4 min. The parameters recorded during the procedure were the regional cerebral oxyhemoglobin and deoxyhemoglobin concentrations via NIRS, ETCO2, and the respiratory rate. Results: During hyperventilation, ETCO2 values dropped (31.4% ± 12.2%) vs. baseline in all subjects. Changes in cerebral oximetry were observed only in those subjects (n = 30) who registered a decrease (%) in ETCO2 of 37.58% ± 10.34%, but not in the subjects (n = 16) for which the decrease in ETCO2 was 20.31% ± 5.6%. According to AUC-ROC analysis, a cutoff value of ETCO2 decrease >26% was found to predict changes in oximetry (AUC-ROC = 0.93, p < 0.0001). Seven subjects reported symptoms, such as dizziness, vertigo, and numbness, throughout the procedure. Conclusions: The rise in the respiratory rate alone cannot effectively predict the occurrence of a cerebral vasoconstrictor response induced by hyperventilation, and synchronous ETCO2 and cerebral oximetry monitoring could be used to validate this clinical test. NIRS seems to be a useful tool in predicting vasoconstriction following hyperventilation.

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“…As far as current trends in fNIRS neuroimaging are concerned, there is a development toward using fNIRS in combination with the measurement of systemic signals [an approach termed “systemic physiology augmented functional near-infrared spectroscopy” (SPA-fNIRS); 92 , 120 for a review see Ref. 108 ], or combining fNIRS with other neuroimaging techniques, such as EEG, 121 – 123 fMRI, 121 , 124 or PET. 125 – 128 Ideally, both approaches can then be combined [ Fig.…”

Section: Fnirs: Neuroimaging Technique With Much Progress and Increas...mentioning

confidence: 99%

Psychedelics and fNIRS neuroimaging: exploring new opportunities

Scholkmann

Vollenweider

2022

Neurophoton.

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. In this Outlook paper, we explain to the optical neuroimaging community as well as the psychedelic research community the great potential of using optical neuroimaging with functional near-infrared spectroscopy (fNIRS) to further explore the changes in brain activity induced by psychedelics. We explain why we believe now is the time to exploit the momentum of the current resurgence of research on the effects of psychedelics and the momentum of the increasing progress and popularity of the fNIRS technique to establish fNIRS in psychedelic research. With this article, we hope to contribute to this development.

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Systemic physiology augmented functional near-infrared spectroscopy: a powerful approach to study the embodied human brain

Cited by 31 publications

References 138 publications

Frontal lobe hemodynamics detected by functional near-infrared spectroscopy during head-up tilt table tests in patients with electrical burns

Frontal lobe hemodynamics detected by functional near-infrared spectroscopy during head-up tilt table tests in patients with electrical burns

Near-Infrared Spectroscopy Usefulness in Validation of Hyperventilation Test

Psychedelics and fNIRS neuroimaging: exploring new opportunities

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