Psychedelics and fNIRS neuroimaging: exploring new opportunities

Scholkmann, Felix; Vollenweider, Franz X.

doi:10.1117/1.nph.10.1.013506

Cited by 7 publications

(8 citation statements)

References 152 publications

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“…Despite the well-known role of 5-HT2A receptors in cardiovascular functioning [26,47], only limited research has been devoted to a possible disentanglement of vascular and neuronal constituents of psychedelic drug action [48,49]. A future combination of voltage imaging with techniques such as pulse oximetry [35], functional near-infrared spectroscopy [50], and/or laser speckle contrast imaging [51] might help and tell both constituents apart.…”

Section: Discussionmentioning

confidence: 99%

Cortical Correlates of Psychedelic-Induced Shaking Behavior Revealed by Voltage Imaging

Buchborn

Lyons

Song

et al. 2023

IJMS

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(1) From mouse to man, shaking behavior (head twitches and/or wet dog shakes) is a reliable readout of psychedelic drug action. Shaking behavior like psychedelia is thought to be mediated by serotonin 2A receptors on cortical pyramidal cells. The involvement of pyramidal cells in psychedelic-induced shaking behavior remains hypothetical, though, as experimental in vivo evidence is limited. (2) Here, we use cell type-specific voltage imaging in awake mice to address this issue. We intersectionally express the genetically encoded voltage indicator VSFP Butterfly 1.2 in layer 2/3 pyramidal neurons. We simultaneously capture cortical hemodynamics and cell type-specific voltage activity while mice display psychedelic shaking behavior. (3) Shaking behavior is preceded by high-frequency oscillations and overlaps with low-frequency oscillations in the motor cortex. Oscillations spectrally mirror the rhythmics of shaking behavior and reflect layer 2/3 pyramidal cell activity complemented by hemodynamics. (4) Our results reveal a clear cortical fingerprint of serotonin-2A-receptor-mediated shaking behavior and open a promising methodological avenue relating a cross-mammalian psychedelic effect to cell-type specific brain dynamics.

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Section: Discussionmentioning

confidence: 99%

Cortical Correlates of Psychedelic-Induced Shaking Behavior Revealed by Voltage Imaging

Buchborn

Lyons

Song

et al. 2023

IJMS

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“…Researchers studying children's development (Noreika et al, 2020 ; Turk et al, 2022 ) and spoken communication (Kelsen et al, 2022 ) have also signaled that longitudinal hyperscanning could advance their research. Moreover, others suggest that fNIRS would be a suitable technique to address the lack of longitudinal data pertaining to the development of cognition in infants and children (Miguel et al, 2019 ; Sato et al, 2021 ), neurodegenerative diseases (Bonilauri et al, 2020 ; Srinivasan et al, 2023 ), psychiatric disorders (Kumar et al, 2017 ; Ho et al, 2020 ), hearing after receiving a cochlear implant (McKay et al, 2015 ; Anderson C. A. et al, 2017 ; Zhou et al, 2022 ), and use of psychedelic substances (Scholkmann and Vollenweider, 2022 ). While these authors do not explicitly refer to hyperscanning as their technique of choice, INS recorded with fNIRS over multiple sessions could address several methodological aspirations (i.e., ecological validity, two-brain design, longitudinal assessment) at once.…”

Section: Ecologically Valid Measurements Of Social Interactionmentioning

confidence: 99%

Mobile fNIRS for exploring inter-brain synchrony across generations and time

Moffat,

Casale,

Cross

2024

Front. Neuroergonomics

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While still relatively rare, longitudinal hyperscanning studies are exceptionally valuable for documenting changes in inter-brain synchrony, which may in turn underpin how behaviors develop and evolve in social settings. The generalizability and ecological validity of this experimental approach hinges on the selected imaging technique being mobile–a requirement met by functional near-infrared spectroscopy (fNIRS). fNIRS has most frequently been used to examine the development of inter-brain synchrony and behavior in child-parent dyads. In this position paper, we contend that dedicating attention to longitudinal and intergenerational hyperscanning stands to benefit the fields of social and cognitive neuroscience more broadly. We argue that this approach is particularly relevant for understanding the neural mechanisms underpinning intergenerational social dynamics, and potentially for benchmarking progress in psychological and social interventions, many of which are situated in intergenerational contexts. In line with our position, we highlight areas of intergenerational research that stand to be enhanced by longitudinal hyperscanning with mobile devices, describe challenges that may arise from measuring across generations in the real world, and offer potential solutions.

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“…Exciting prospects exist to use fNIRS as a neuro-feedback tool as a therapy. NIRS may also be applied to measure the effects of psychedelic substances 23 …”

Section: Fnirs Applicationsmentioning

confidence: 99%

“…NIRS may also be applied to measure the effects of psychedelic substances. 23 Further, NIRS also offers to be a promising tool to assess the neural correlates of how medical professionals gain expertise with new surgical skills and techniques, making NIRS a useful method not only for patient assessment, but also for medical training. 24 In conclusion, we believe that this special issue represents a milestone in the development of fNIRS at its mature age of 30.…”

Section: Fnirs Applicationsmentioning

confidence: 99%