Systemic multi‐organ involvement in chronic active Epstein–Barr virus disease

Kim, Hye Jin; Lee, Eunjung; Moon, Sena; Lee, Jae Young; Kang, Jin Han

doi:10.1111/ped.12735

“…Hepatitis B virus (HBV) and hepatitis C virus (HCV) play significant roles in chronic hepatitis, liver cirrhosis and liver carcinoma [ 4 ]. The Epstein-Barr virus (EBV) can cause a chronic active infection characterized by chronic or recurrent infectious mononucleosis-like symptoms, stomach cancer, lung cancer, nasopharyngeal carcinoma, multiple sclerosis, and even systemic multi-organ involvement [ 5 ]. The human immunodeficiency virus (HIV) can invade vital cells in the human immune system and cause the progressive failure of the immune system named acquired immunodeficiency syndrome (AIDS) [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

A Review of the Antiviral Role of Green Tea Catechins

Xu

¹

,

Zhao

²

,

Zheng

³

2017

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Over the centuries, infectious diseases caused by viruses have seriously threatened human health globally. Viruses are responsible not only for acute infections but also many chronic infectious diseases. To prevent diseases caused by viruses, the discovery of effective antiviral drugs, in addition to vaccine development, is important. Green tea catechins (GTCs) are polyphenolic compounds from the leaves of Camellia sinensis. In recent decades, GTCs have been reported to provide various health benefits against numerous diseases. Studies have shown that GTCs, especially epigallocatechin-3-gallate (EGCG), have antiviral effects against diverse viruses. The aim of this review is to summarize the developments regarding the antiviral activities of GTCs, to discuss the mechanisms underlying these effects and to offer suggestions for future research directions and perspectives on the antiviral effects of EGCG.

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“…Hepatitis B virus (HBV) and hepatitis C virus (HCV) play significant roles in chronic hepatitis, liver cirrhosis and liver carcinoma [4]. The Epstein-Barr virus (EBV) can cause a chronic active infection characterized by chronic or recurrent infectious mononucleosislike symptoms, stomach cancer, lung cancer, nasopharyngeal carcinoma, multiple sclerosis, and even systemic multi-organ involvement [5]. The human immunodeficiency virus (HIV) can invade vital cells in the human immune system and cause the progressive failure of the immune system named acquired immunodeficiency syndrome (AIDS) [6].…”

Section: Introductionmentioning

confidence: 99%

The Antiviral Role of Green Tea Polyphenols

Xu¹,

Zhao²,

Zheng³

2020

Prime Archives in Molecular Sciences

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Over the centuries, infectious diseases caused by viruses have seriously threatened human health globally. Viruses are responsible not only for acute infections but also many chronic infectious diseases. To prevent diseases caused by viruses, the discovery of effective antiviral drugs, in addition to vaccine development, is important. Green tea catechins (GTCs) are polyphenolic compounds from the leaves of Camellia sinensis. In recent decades, GTCs have been reported to provide various health benefits against numerous diseases. Studies have shown that GTCs, especially epigallocatechin-3-gallate (EGCG), have antiviral effects against diverse viruses. The aim of this review is to summarize the developments regarding the antiviral activities of GTCs, to discuss the mechanisms underlying these effects and to offer suggestions for future research directions and perspectives on the antiviral effects of EGCG.

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“…Other clinical manifestations are possible in addition to the triad of symptomslymphadenopathy, tonsillitis, hepatosplenomegaly in case of IM, that are associated with heart damage (myocardium, pericardium, coronary arteries), central and peripheral nervous system (meningitis, meningoencephalitis), kidney (nephritis), pancreatitis orchites and others [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Condition of Lipid Peroxide Oxidation and Antioxidant System in Patients With Infectious Mononucleosis

Shustval

¹

,

Лядова

²

,

Volobueva

³

et al. 2018

The Journal of v. N. Karazin Kharkiv National University, Series "Medicine"

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The indicators of the activity of lipid peroxidation and the antioxidant system were studied in dynamics in 158 patients with infectious mononucleosis depending on the severity of the clinical course of the disease. It is proved that lipid peroxidation is significantly activated in patients with infectious mononucleosis as the severity of the disease increases and therefore increases the oxidative activity of blood plasma, the concentration of dyne conjugates and malondialdehyde in the blood, decreases the activity of antioxidant enzymes of erythrocytes (catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase), glutathione peroxidase and glutathione reductase activity in plasma and lowering the concentration of total and reduced glutathione in the blood, as well as reduce the antioxidant activity of blood plasma and erythrocytes. Lipid peroxidation significantly increase and the activity of the antioxidant system decrease in patients with infectious mononucleosis in the acute period of the disease, as evidenced by the increased concentration of dyne conjugates, malonic dialdehyde and total oxidative plasma activity in the blood, reduced activity of the total antioxidant activity of plasma and erythrocytes, the decrease in the activity of antioxidant enzymes of erythrocytes catalase, superoxide dismutase, glutathione peroxidase, glutathione peroxidase and glutathione reductase of blood plasma, the decrease in the concentration of glutathione in the blood. The most pronounced disorders of lipid peroxidation and antioxidant system activity were found in patients with moderate-severe and severe infectious mononucleosis. The development of cytolytic syndrome in infectious mononucleosis is associated with the action of reactive oxygen forms species and lipid hydroperoxide.

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Systemic multi‐organ involvement in chronic active Epstein–Barr virus disease

Cited by 3 publications

References 7 publications

A Review of the Antiviral Role of Green Tea Catechins

A Review of the Antiviral Role of Green Tea Catechins

The Antiviral Role of Green Tea Polyphenols

Condition of Lipid Peroxide Oxidation and Antioxidant System in Patients With Infectious Mononucleosis

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