Condition of Lipid Peroxide Oxidation and Antioxidant System in Patients With Infectious Mononucleosis

Abstract

The indicators of the activity of lipid peroxidation and the antioxidant system were studied in dynamics in 158 patients with infectious mononucleosis depending on the severity of the clinical course of the disease. It is proved that lipid peroxidation is significantly activated in patients with infectious mononucleosis as the severity of the disease increases and therefore increases the oxidative activity of blood plasma, the concentration of dyne conjugates and malondialdehyde in the blood, decreases the activity of antioxidant enzymes of erythrocytes (catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase), glutathione peroxidase and glutathione reductase activity in plasma and lowering the concentration of total and reduced glutathione in the blood, as well as reduce the antioxidant activity of blood plasma and erythrocytes. Lipid peroxidation significantly increase and the activity of the antioxidant system decrease in patients with infectious mononucleosis in the acute period of the disease, as evidenced by the increased concentration of dyne conjugates, malonic dialdehyde and total oxidative plasma activity in the blood, reduced activity of the total antioxidant activity of plasma and erythrocytes, the decrease in the activity of antioxidant enzymes of erythrocytes catalase, superoxide dismutase, glutathione peroxidase, glutathione peroxidase and glutathione reductase of blood plasma, the decrease in the concentration of glutathione in the blood. The most pronounced disorders of lipid peroxidation and antioxidant system activity were found in patients with moderate-severe and severe infectious mononucleosis. The development of cytolytic syndrome in infectious mononucleosis is associated with the action of reactive oxygen forms species and lipid hydroperoxide.

Free radical damage: role in varicella zoster virus infection

“…The data above indicated that chickenpox patients with moderate and severe course of the disease developed a pronounced imbalance between the state of the oxidative and antioxidant systems, which was accompanied by an increase in the free radical oxidation of fatty acids and the accumulation of toxic DC and MDA increased concentration [7,13]. A marked deficiency of glutathione, which normally inactivates free radicals [14], also developed and could have a negative impact on the course of the disease and its complications.…”

“…It accumulates in tissues in patients with moderate to severe chickenpox as a result of a decrease in glutathione reductase activity. Oxidized glutathione inactivates membrane adenosine triphosphatase, hexokinase, glucose-6-dehydrogenase, inhibits phosphorylation and nuclear RNA synthesis, and inhibits protein synthesis due to the formation of protein-thiol-glutathione crosslinks [7,15].…”

“…In the past decade it became accepted that free radicals, lipid peroxidation and antioxidant defence play a role in various tissues damages, thus in certain infectious diseases as well. In parti cular, it was found that there is an intensification of the free radical oxidation of lipids and a deepening of antioxidant deficiency in the development process of salmonellosis [1], viral hepatitis [2,3], pseudotuberculosis, yersiniosis [4], erysipelas [5], diphtheria [6] and infectious mononucleosis [7]. These changes correlate with the disease severity.…”