Systemic modulation of the stability of pluronic hydrogel by a small amount of graphene oxide

Won, Da-Ae; Kim, Manse; Tae, Giyoong

doi:10.1016/j.colsurfb.2015.03.002

Cited by 20 publications

(12 citation statements)

References 32 publications

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“…Different hydrophobic materials are used to conjugate on hydrophilic units to form thermosensitive materials. Many studies have been performed based on this approach, and different hydrophobic materials, such as cholesterol [ 184 , 185 ], poly L-lactide (PLLA) [ 186 , 187 , 188 , 189 ], beta glycerophosphate (β-GP) [ 190 , 191 ] and pluronic F127 (F127) [ 192 , 193 ] have been used to synthesize thermosensitive hydrogels and nanogels for biomedical applications.…”

Section: Thermosensitive Polymersmentioning

confidence: 99%

“…Pluronic F127 is a hydrophilic non-ionic copolymer, based on non-toxic FDA-approved PEG and polypropylene glycol (PPG) segments, which is widely used in biomedical applications [ 192 , 199 , 200 , 201 , 202 , 203 ]. Sharma et al developed a thermosensitive nanogel based on pluronic F127 as the carrier for the delivery of lidocaine (Lid) and prilocaine (Pl) and demonstrated by in-vitro and in-vivo experiments that the thermosensitivity of the carrier improves the delivery of Lid and PI [ 193 ].…”

Section: Thermosensitive Polymersmentioning

confidence: 99%

See 1 more Smart Citation

Thermoresponsive Nanogels Based on Different Polymeric Moieties for Biomedical Applications

Ghaeini-Hesaroeiye

Bagtash

Boddohi

et al. 2020

Gels

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Nanogels, or nanostructured hydrogels, are one of the most interesting materials in biomedical engineering. Nanogels are widely used in medical applications, such as in cancer therapy, targeted delivery of proteins, genes and DNAs, and scaffolds in tissue regeneration. One salient feature of nanogels is their tunable responsiveness to external stimuli. In this review, thermosensitive nanogels are discussed, with a focus on moieties in their chemical structure which are responsible for thermosensitivity. These thermosensitive moieties can be classified into four groups, namely, polymers bearing amide groups, ether groups, vinyl ether groups and hydrophilic polymers bearing hydrophobic groups. These novel thermoresponsive nanogels provide effective drug delivery systems and tissue regeneration constructs for treating patients in many clinical applications, such as targeted, sustained and controlled release.

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Section: Thermosensitive Polymersmentioning

confidence: 99%

Section: Thermosensitive Polymersmentioning

confidence: 99%

Thermoresponsive Nanogels Based on Different Polymeric Moieties for Biomedical Applications

Ghaeini-Hesaroeiye

Bagtash

Boddohi

et al. 2020

Gels

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“…A great deal of work has been reported regarding the reinforcing effect of GO in biopolymer matrices . Won et al found that incorporation of small amount of GO could significantly improve the stability of Pluronic as well as its mechanical stiffness through strong hydrophobic interaction between GO surfaces and PPO blocks of Pluronic backbone . In addition to hydrophobic interaction, hydroxyl groups of GO and Pluronic are able to form hydrogen bonding .…”

Section: Introductionmentioning

confidence: 99%

“…Won et al found that incorporation of small amount of GO could significantly improve the stability of Pluronic as well as its mechanical stiffness through strong hydrophobic interaction between GO surfaces and PPO blocks of Pluronic backbone . In addition to hydrophobic interaction, hydroxyl groups of GO and Pluronic are able to form hydrogen bonding . The large surface area together with superior electrical conductivity give graphene a pathway for charge transfer.…”

Section: Introductionmentioning

confidence: 99%

Injectable poloxamer/graphene oxide hydrogels with well‐controlled mechanical and rheological properties

Rad

Vahabi

Formela

et al. 2019

Polymers for Advanced Techs

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Although significant progress has been made in the design and application of injectable hydrogels for biomedical applications, concurrent control of rheological and mechanical properties of injectable hydrogels has remained as an open challenge to the researchers. In this work, we introduce and put into practice a photo-curable poloxamer (also known as Pluronic)/graphene oxide (Plu/GO) injectable hydrogel with well-controlled rheological and mechanical properties. Acrylate group was anchored to hydrogel structure to endow photo-crosslinking ability through decelerating degradation rate of poloxamer hydrogels after injection. It was found that the modified Plu remains stable in biological media for a long-term period without significant weight loss. Rheological properties of hydrogels were also carried out as essential prerequisite for an ideal injectability via frequency sweep, flow curve, recovery, and yield stress before and after modification, signifying shear-thinning behavior of Plu/GO hydrogels with high recoverability. The viscosity of shear-thinning-like hydrogels dropped at higher shear stress, which facilitated injection process. Moreover, mechanical behavior of Plu was optimized by manipulating the content of Plu, degree of modification with reactive precursor, curing, and particularly incorporation of GO without deteriorating effects on rheological behavior of Plu.

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“…Other unique properties such as biocompatibility, responsiveness to various kinds of stimuli, ultralow surface friction, and environmental friendliness further qualifies them as good biomedical materials . Recently, substantial attentions have been paid to hydrogels as useful materials for functional release matrices or engineered tissues . The wide range of mechanical properties of hydrogels gives hope for possible use in various products such as contact lenses, wound dressings, or artificial organs…”

Section: Introductionmentioning

confidence: 99%

The effects of graphene oxide on the properties and drug delivery of konjac glucomannan hydrogel

Yuan

Yan

et al. 2017

J of Applied Polymer Sci

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Konjac glucomannan (KGM) hydrogel has good potential application in food and medical science, although to achieve this, the physical and mechanical properties need further improvement. In this study, graphene oxide (GO) was used to improve the functionality of KGM hydrogel. KGM/GO hydrogels were prepared by freezing the alkaline KGM/GO sols. Rotational rheometer was used to study the rheological properties of different alkaline KGM/GO sols. Fourier transform infrared, Raman, differential scanning calorimetry, thermogravimetric analyses, and scanning electron microscopy were used to evaluate the structure and properties of the hydrogels. In addition, different pH solutions and an in vitro assay were used to study the swelling property and the release behavior of KGM/GO hydrogels, respectively. The result revealed strong hydrogen-bond interaction between KGM and GO. The incorporation of GO highly improved the gel properties of KGM/GO sol, higher thermal stability, and more compact structure of KGM/GO hydrogels. KGM/GO hydrogels showed better swelling properties in deionized-distilled water and pH 7.2 PBS. The release of 5-aminosalicylic acid (5-ASA) from KGM/GO (KG4) hydrogel was different in various pH media, but the initial burst release effect was very severe. Therefore, incorporation of GO have a good potential in enhancing the properties of KGM hydrogel, but KGM/GO hydrogel is not an ideal carrier for 5-ASA release.

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Systemic modulation of the stability of pluronic hydrogel by a small amount of graphene oxide

Cited by 20 publications

References 32 publications

Thermoresponsive Nanogels Based on Different Polymeric Moieties for Biomedical Applications

Thermoresponsive Nanogels Based on Different Polymeric Moieties for Biomedical Applications

Injectable poloxamer/graphene oxide hydrogels with well‐controlled mechanical and rheological properties

The effects of graphene oxide on the properties and drug delivery of konjac glucomannan hydrogel

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