Systemic Lupus Erythematosus with Widespread Subcutaneous Fat Calcification

Rj, Powell

doi:10.1177/003591577406700319

Cited by 19 publications

(6 citation statements)

References 2 publications

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“…The pathogenesis of this condition is unknown, but it has been proposed that calcification is a result of tissue ischemia secondary to a pressure effect caused by steroid-induced hypertrophied adipose cells. 3 This is consistent with our patient, who had taken oral prednisone for many years prior to developing calcifications.…”

supporting

confidence: 92%

“…2 Elevated MIF levels in lacrimal fluids and sera and overexpression MIF proteins in the entire epidermal layer have been demonstrated in AD. 3 MIF-173G/C polymorphism within the promoter region of MIF gene has been associated with susceptibility to many immune/inflammatory diseases. 4 However, little is known about how MIF promoter 173G/C polymorphism may contribute to AD risk.…”

mentioning

confidence: 99%

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Systemic lupus erythematosus with dystrophic calcifications

Viera

Alonso‐Llamazares

2012

Int J Dermatol

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supporting

confidence: 92%

mentioning

confidence: 99%

Systemic lupus erythematosus with dystrophic calcifications

Viera

Alonso‐Llamazares

2012

Int J Dermatol

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“…Another explanation for soft tissue calcification is a pressure phenomenon producing ischaemia (Powell et al, 1974). However this is not the case in our patient, since she had the calcifications also in the chest and abdominal walls.…”

Section: Discussionmentioning

confidence: 51%

“…It is less commonly found in systemic lupus erythematosus (SLE). Only few cases of SLE with associated soft tissue calcification have been reported (Keats, 1961;Coltoiu et al, 1968;Kabir and Malkinson, 1969;Savin, 1971;Dubois, 1974;Powell et al, 1974;Quismorio et al, 1975;Budin and Feldman, 1975). No effective therapy for calcification is known, though temporary benefit has been reported with the use of chelating agents and with diphosphonate.…”

mentioning

confidence: 99%

Extensive soft tissue calcification (calcinosis universalis) in systemic lupus erythematosus.

Weinberger¹,

Kaplan²,

Myers³

1979

Annals of the Rheumatic Diseases

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SUMMARY A 21-year-old woman with long-standing systemic lupus erythematosus developed extensive calcification of the soft tissues of the thoracic and abdominal walls and extremities early in her illness, and these calcifications gradually disappeared over the course of her disease. The extent of this calcinosis and apparent spontaneous regression are unusual events in systemic lupus erythematosus.

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“…20 Powell developed a theory that the formation of calcifications is influenced by local ischemia of tissues related to the compression of adipose tissue overgrown under the influence of steroids. 21 The hypothesis about the influence of ischemia on calcification formation is supported by the observation of increased GLUT-1 (hypoxia associated glucose transporter molecule) expression in patients with lsSSc and dcSSc calcifications. 22 The research of Okada, who observed more frequent formation of calcifications in SLE patients with normal parameters of calcium-phosphate metabolism receiving vitamin D 3 (alfacalcidiol) supplementation and patients with renal lupus (excluding patients with end-stage renal failure), are noteworthy.…”

Section: Resultsmentioning

confidence: 98%

Dystrophic calcifications in case of a patient with systemic lupus erythematosus – case report and literature review

et al. 2021

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Introduction: Cutis calcification is the deposition of calcium in the skin and subcutaneous tissues and is classified into four subsets. Dystrophic calcifications are the most common type of skin calcification, occurring mainly in damaged tissues or in course of autoimmune disease. However, the coexistance of systemic lupus erythematosus (SLE) and soft tissue calcification is described rarely. Aim: This article presents a case of dystrophic calcifications in the buttocks area in a 49-year-old woman with a 17-year history of SLE. Case study: We report a case of 49-year-old women with SLE who developed nodular lesions in the buttock area. The radiological and histopatological examinations of the nodules showed presence of calcifications. The calcium metabolism parameters were in a normal range. The diagnosis of dystrophic calcinosis in the course of SLE was established. Results and discussion: Dystrophic calcifications associated with autoimmune diseases are common, but occur rarely in SLE. It should be noted that patients with SLE can also develop calcifications of different types like metastatic or iatrogenic. Dystrophic calcifications in SLE usually present as small nodules on buttocks or limbs. The pathophysiology remains unclear, however, there are some theories that inflammation and vascular ischemia play a role in its process. Conclusions: Calcifications in case of patients with SLE rarely require treatment. Several pharmacologic and surgical therapies have been tested with variable results. Additional research to establish an accepted treatment algorithm should be conducted.

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Systemic Lupus Erythematosus with Widespread Subcutaneous Fat Calcification

Cited by 19 publications

References 2 publications

Systemic lupus erythematosus with dystrophic calcifications

Systemic lupus erythematosus with dystrophic calcifications

Extensive soft tissue calcification (calcinosis universalis) in systemic lupus erythematosus.

Dystrophic calcifications in case of a patient with systemic lupus erythematosus – case report and literature review

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