Systemic lupus erythematosus increases risk of incident atrial fibrillation: A systematic review and <scp>meta‐analysis</scp>

Chen, Yanlin; Fu, Lü; Pu, Sijia; Xue, Yumei

doi:10.1111/1756-185x.14403

Cited by 10 publications

(9 citation statements)

References 34 publications

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“…In addition, a previous report showed that association was reported between glaucoma and various systemic diseases, including metabolic syndrome, autoimmune disease, and cardiac disease 21–23 . Recent studies have suggested there is a potential link between glaucoma and systemic autoimmune diseases, which may result from the chronic inflammation and autoimmunity that can contribute to the development of cardiovascular and metabolic disorders, such as atherosclerosis and diabetes 24–26 . Corticosteroids (glucocorticoids) are used as potent anti‐inflammatory agents, and it is indicated that corticosteroid treatment induces glaucoma 27,28 .…”

Section: Discussionmentioning

confidence: 99%

“…[21][22][23] Recent studies have suggested there is a potential link between glaucoma and systemic autoimmune diseases, which may result from the chronic inflammation and autoimmunity that can contribute to the development of cardiovascular and metabolic disorders, such as atherosclerosis and diabetes. [24][25][26] Corticosteroids (glucocorticoids) are used as potent anti-inflammatory agents, and it is indicated that corticosteroid treatment induces glaucoma. 27,28 Similarly, our results indicated that corticosteroid treatment could induce glaucoma, and developing glaucoma among the <180 days corticosteroid group was 2.75 (95% CI 1.55-5.05).…”

Section: Discussionmentioning

confidence: 99%

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Risk of new‐onset glaucoma in patients with systemic lupus erythematosus: A nationwide, population‐based cohort study

et al. 2023

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To explore the relationship of systemic lupus erythematosus (SLE) and subsequent glaucoma incidence. Patients with SLE were defined as those newly diagnosed by International Classification of Diseases, 9th Revision, Clinical Modification (ICD‐9‐CM) code 710.0 in at least 3 outpatient visits or 1 hospitalization during 2000–2012 by using the National Health Insurance Research Database. We selected a non‐SLE comparison cohort at a 1:1 ratio by propensity score matching on age, gender, index date, comorbidities and medications. We identified outcome as the incident glaucoma in patients with SLE. Multivariate Cox regression analysis was used to calculate the adjusted hazard ratio (aHR) in 2 groups. Kaplan‐ Meier analysis was performed to estimate the cumulative incidence rate between both groups. There were 1743 patients who were included in the SLE group and non‐SLE group. The aHR of glaucoma was 1.56 (95% CI = 1.03–2.36) in the SLE group, compared to non‐SLE controls. Subgroup analysis showed that SLE patients present greater risk of glaucoma, especially in males (aHR = 3.76; 95% CI, 1.5–9.42), and the P for interaction between gender and risk of glaucoma was 0.026. This cohort study showed that patients with SLE have 1.56‐fold risk of glaucoma development. Gender acted as an effect modifier between SLE and the risk of new‐onset glaucoma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Risk of new‐onset glaucoma in patients with systemic lupus erythematosus: A nationwide, population‐based cohort study

et al. 2023

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“…Systemic lupus erythematosus (SLE) is a chronic autoimmune disease and involves almost every organ in the body with a broad spectrum of manifestations 1–3 . Neuropsychiatric systemic lupus erythematosus (NPSLE) is one of the severe complications of SLE with increased morbidity and mortality 4 .…”

Section: Introductionmentioning

confidence: 99%

“…Systemic lupus erythematosus (SLE) is a chronic autoimmune disease and involves almost every organ in the body with a broad spectrum of manifestations. [1][2][3] Neuropsychiatric systemic lupus erythematosus (NPSLE) is one of the severe complications of SLE with increased morbidity and mortality. 4 A threefold to tenfold increase in mortality rate is observed in NPSLE compared with SLE without neuropsychiatric events 5 and the general population, 6 respectively.…”

Section: Introductionmentioning

confidence: 99%

Performance of eye sign combined with increased interleukin‐6 in cerebrospinal fluid in patients with neuropsychiatric lupus erythematosus

Shi

Liu

et al. 2023

Int J of Rheum Dis

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Objectives To ascertain whether microvascular alterations of eye sign combined with intrathecal concentrations of interleukin‐6 (IL‐6) can predict the development of neuropsychiatric systemic lupus erythematosus (NPSLE). Methods Cerebrospinal fluid (CSF) and serum samples of IL‐6 were collected and measured at the same time for patients with SLE who were consecutively enrolled. Patients with a diagnosis of NPSLE were identified. Eye sign examinations according to our criteria were performed and scored for all SLE patients. Demographic and clinical parameters were compared between groups to identify potential predictors for NPSLE using multivariable logistic regression analysis. The performance of potential predictors from eye sign along with IL‐6 in the CSF was assessed. Results A total of 120 patients with SLE were enrolled; 30 with NPSLE and 90 with non‐NPSLE. No significant positive correlation was observed between CSF level and serum level of IL‐6. CSF IL‐6 was significant higher in the NPSLE group than the non‐NPSLE (P < 0.001) group. Multivariable logistic analysis revealed that total score, ramified loops, and microangioma of eye sign were predictors for NPSLE after adjusting for SLE Disease Activity Index (SLEDAI) and antiphospholipid antibody (APL). Total score, ramified loops, microangioma of eye sign, and SLEDAI remain significant predictors for NPSLE after adjusting for CSF IL‐6. Using receiver operating characteristics curve analysis, the cut‐off point of potential predictors was applied in multivariable logistic analysis; APL, total score, ramified loops, and microangioma of eye sign remain significant predictors for NPSLE after adjusting for CSF IL‐6. Conclusion Specific microvascular alterations of eye sign are predictors for the development of NPSLE in addition to increased IL‐6 in the CSF.

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“…[20][21][22][23][24] To address these issues, we performed a meta-analysis of previously published research to look at the link between circulating leptin levels and OA susceptibility as well as the correlation between leptin and LEPR polymorphisms and OA risk. [25][26][27] This study's objective was to provide a thorough and current analysis of the research on these crucial issues, which may guide future studies and clinical OA care practices.…”

Section: Introductionmentioning

confidence: 99%

Circulating leptin level in osteoarthritis and associations between leptin receptor polymorphisms and disease susceptibility: A meta‐analysis

Lee

Song

2023

Int J of Rheum Dis

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Objective This study aimed to systemically review the evidence on the relationship between the circulating leptin levels and osteoarthritis (OA), and the association between leptin and leptin receptor (LEPR) polymorphisms and OA susceptibility. Methods To find relevant papers (up to February 2023) examining the association between circulating leptin levels, LEPR polymorphisms, and OA, the PUBMED, EMBASE, and Cochrane databases were searched. We performed a meta‐analysis to examine the levels of synovial and serum/plasma leptin in OA patients compared with healthy controls, as well as the relationship between OA and LEPR polymorphisms. Results Data from 15 investigations, totaling 2197 patients with OA and 2546 controls, were included in the meta‐analysis. There were statistically significant differences in the levels of circulating leptin between the OA and control groups (standardized mean difference [SMD] 2.178, 95% confidence interval [CI] 1.208‐3.139, P = 0.001). Leptin levels were also substantially greater in European, Asian, and Arab groups among OA patients. After adjusting for age, sex, and/or body mass index, the leptin levels of patients with OA were significantly higher. Similarly, regardless of sample size (n < 100 and n ≥ 100) or year of publication, leptin levels were considerably higher in the OA group. In addition, the synovial leptin level was greater in the OA group than in the control group (SMD 0.783; 95% CI 0.247‐1.319, P = 0.004). In the LEPR rs1137101 polymorphism, the OA and AA genotypes were significantly associated (odds ratio 0.282, 95% CI 0.126‐0.629, P = 0.002), according to the meta‐analysis. Ethnic stratification revealed an association between OA and the LEPR rs1137101 AA genotype in Asian and Arab populations. Conclusion The results of this meta‐analysis indicate that patients with OA had considerably greater levels of circulating leptin than did control individuals. In addition, synovial leptin levels were greater in OA patients than in healthy individuals, and the LEPR rs1137101 polymorphism was linked to an increased risk of developing OA. These results imply that leptin participates in the onset and progression of OA.

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Systemic lupus erythematosus increases risk of incident atrial fibrillation: A systematic review and meta‐analysis

Cited by 10 publications

References 34 publications

Risk of new‐onset glaucoma in patients with systemic lupus erythematosus: A nationwide, population‐based cohort study

Risk of new‐onset glaucoma in patients with systemic lupus erythematosus: A nationwide, population‐based cohort study

Performance of eye sign combined with increased interleukin‐6 in cerebrospinal fluid in patients with neuropsychiatric lupus erythematosus

Circulating leptin level in osteoarthritis and associations between leptin receptor polymorphisms and disease susceptibility: A meta‐analysis

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