Systemic lupus erythematosus following vaccination against 2009 influenza A (H1N1)

Is Systemic Lupus Erythematosus Associated With a Declined Immunogenicity and Poor Safety of Influenza Vaccination?

“… 38 , 39 The sporadic severe adverse events such as glomerulonephritis and even death are continuously reported. 6 , 40 This may lead to the physicians’ reluctance to prescribe vaccination due to concerns about its safety. SLE patients have lower flu shot coverage than their counterparts with other systemic inflammatory diseases, for example, systemic sclerosis, rheumatoid arthritis, or vasculitis.…”

“…Etiological studies show virus infection, polluted environment, ultraviolet, vaccination, and even see foods could cause SLE symptom among those susceptible individuals. 6 , 41 It is very hard to elucidate some rare cases of serious adverse events and flare-up among SLE patient with flu vaccination. Normally, the serious adverse event is a case report, thus it has no statistical significance.…”

“…Although early in the United States, the safety of flu vaccine in SLE patients has been approved in several studies, 3 – 5 there are still more accumulated adverse events afterward. 6 – 9 The rheumatologists indicated the theory. Because virus infection can cause the exacerbation of SLE or aggravate the activity of SLE, it is reasonable that the dead virus in vaccine may lead to harmful immune responses by the same mechanism as the pathogenic virus doing for SLE.…”

“…Because virus infection can cause the exacerbation of SLE or aggravate the activity of SLE, it is reasonable that the dead virus in vaccine may lead to harmful immune responses by the same mechanism as the pathogenic virus doing for SLE. 6 – 9 On the other hand, different studies showed conflicting results in immunogenicity of SLE patients with flu vaccination. Five studies 4 , 5 , 10 – 12 reported significantly decreased immunogenicity of flu-vaccinated SLE patients compared with the healthy control, whereas 4 other studies 3 , 13 – 15 did not prove so.…”

HIV-1 gp120 Vaccine Induces Affinity Maturation in both New and Persistent Antibody Clonal Lineages

“…Using techniques similar to those employed in this study, we found that ϳ20% of isolated rMAbs from subjects immunized with trivalent inactivated influenza vaccine were polyreactive (B. F. Haynes, unpublished data). Vaccinations have been rarely reported to reactivate autoimmune disease (35); however, most evidence supports the safety of killed or recombinant vaccines in autoimmune disease patients (1,7,32,52). In cases where it is observed, autoantibody increases following vaccination have been reported to have no clinical consequences (1,52).…”