Vaccinations and risk of systemic lupus erythematosus and rheumatoid arthritis: A systematic review and meta-analysis

Wang, Bin; Shao, Xiaorong; Wang, Dan; Xu, Dongmei; Zhang, Jin‐an

doi:10.1016/j.autrev.2017.05.012

Cited by 34 publications

(22 citation statements)

References 85 publications

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“…There are also some observational studies on the link between virus infections and SLE (Hanlon, Avenell, Aucott, & Vickers, 2014;Rasmussen, Nielsen, Houen, & Jacobsen, 2016;Zandman-Goddard et al, 2009 Guiducci, & Coffman, 2007;Fagone, Muthumani, et al, 2014;Oon, Wilson, & Wicks, 2016). Some studies find that vaccinations against virus infections can also increase risk of SLE (Agmon-Levin et al, 2014;Geier & Geier, 2017;Wang, Shao, Wang, Xu, & Zhang, 2017), which further provides some evidence for et al, 1996;Gröndal et al, 2000). Its important role is also evidenced in our study.…”

Section: Discussionmentioning

confidence: 96%

Key genes and functional coexpression modules involved in the pathogenesis of systemic lupus erythematosus

Yan

Wang

Gao

et al. 2018

Journal Cellular Physiology

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We performed a systematic review of genome-wide gene expression datasets to identify key genes and functional modules involved in the pathogenesis of systemic lupus erythematosus (SLE) at a systems level. Genome-wide gene expression datasets involving SLE patients were searched in Gene Expression Omnibus and ArrayExpress databases. Robust rank aggregation (RRA) analysis was used to integrate those public datasets and identify key genes associated with SLE. The weighted gene coexpression network analysis (WGCNA) was adapted to identify functional modules involved in SLE pathogenesis, and the gene ontology enrichment analysis was utilized to explore their functions. The aberrant expressions of several randomly selected key genes were further validated in SLE patients through quantitative real-time polymerase chain reaction. Fifteen genome-wide gene expression datasets were finally included, which involved a total of 1,778 SLE patients and 408 healthy controls. A large number of significantly upregulated or downregulated genes were identified through RRA analysis, and some of those genes were novel SLE gene signatures and their molecular roles in etiology of SLE remained vague. WGCNA further successfully identified six main functional modules involved in the pathogenesis of SLE. The most important functional module involved in SLE included 182 genes and mainly enriched in biological processes, including defense response to virus, interferon signaling pathway, and cytokine-mediated signaling pathway. This study identifies a number of key genes and functional coexpression modules involved in SLE, which provides deepening insights into the molecular mechanism of SLE at a systems level and also provides some promising therapeutic targets.

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Section: Discussionmentioning

confidence: 96%

Key genes and functional coexpression modules involved in the pathogenesis of systemic lupus erythematosus

Yan

Wang

Gao

et al. 2018

Journal Cellular Physiology

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“…[95][96][97] Although case reports describing temporal association do not provide proof of causation, these reports are complemented by more recent publications relating to large-scale data. 98,99 Of note, a case-control analysis of reports submitted to the US Vaccine adverse event reporting system compared 48 816 reports of SLE to 21 998 controls (reporting adverse events other than SLE). Subjects with SLE were significantly more likely to have received the HPV quadrivalent vaccine (odds ratio 7.626, 95% confidence interval: 3.385-19.366), with a median onset of symptoms ranging between 3 and 37 days post vaccination.…”

Section: Systemic Lupus Erythematosusmentioning

confidence: 99%

Vaccine-induced autoimmunity: the role of molecular mimicry and immune crossreaction

2018

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Since the early 1800s vaccines have saved numerous lives by preventing lethal infections. However, during the past two decades, there has been growing awareness of possible adverse events associated with vaccinations, cultivating heated debates and leading to significant fluctuations in vaccination rates. It is therefore pertinent for the scientific community to seriously address public concern of adverse effects of vaccines to regain public trust in these important medical interventions. Such adverse reactions to vaccines may be viewed as a result of the interaction between susceptibility of the vaccinated subject and various vaccine components. Among the implicated mechanisms for these reactions is molecular mimicry. Molecular mimicry refers to a significant similarity between certain pathogenic elements contained in the vaccine and specific human proteins. This similarity may lead to immune crossreactivity, wherein the reaction of the immune system towards the pathogenic antigens may harm the similar human proteins, essentially causing autoimmune disease. In this review, we address the concept of molecular mimicry and its application in explaining post vaccination autoimmune phenomena. We further review the principal examples of the influenza, hepatitis B, and human papilloma virus vaccines, all suspected to induce autoimmunity via molecular mimicry. Finally, we refer to possible implications on the potential future development of better, safer vaccines.

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“…As a complex autoimmune disease (1), it is characterized by clinical heterogeneity, more common among women (2) and with an estimated prevalence of 20 to 150 cases per 100,000 population (3,4). The pathogenesis of SLE is not fully understood and believed to be a result of a complex interplay between genetic susceptibility (5) and environmental factors in subjects with primary dysregulation in both innate and adaptive immune system with dysregulation of type -1 interferon being a common denominator (6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Immunogenicity, safety and tolerability of anti-pneumococcal vaccination in systemic lupus erythematosus patients: An evidence-informed and PRISMA compliant systematic review and meta-analysis

Adawi

Bragazzi

McGonagle

et al. 2019

Autoimmunity Reviews

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Vaccinations and risk of systemic lupus erythematosus and rheumatoid arthritis: A systematic review and meta-analysis

Cited by 34 publications

References 85 publications

Key genes and functional coexpression modules involved in the pathogenesis of systemic lupus erythematosus

Key genes and functional coexpression modules involved in the pathogenesis of systemic lupus erythematosus

Vaccine-induced autoimmunity: the role of molecular mimicry and immune crossreaction

Immunogenicity, safety and tolerability of anti-pneumococcal vaccination in systemic lupus erythematosus patients: An evidence-informed and PRISMA compliant systematic review and meta-analysis

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