1963
DOI: 10.1172/jci104774
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Systemic Lupus Erythematosus. Cryoprecipitation of Sera

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1964
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Cited by 74 publications
(33 citation statements)
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“…(Received for publication 21 August 1967) With the observations of immune complexes or antigens in the circulation of patients with rheumatoid arthritis (1,2), systemic lupus erythematosus (3,4), and other diseases, much attention has been drawn to their possible significance in the pathogenesis of the lesions in these disorders. Abundant data derived from experimental models have shown that the presence of complexes in the circulation coincides temporally with the development of the lesions, e.g., acute glomerulonephritis and vasculitis (5,6) and chronic glomerulonephritis (7).…”
Section: Platzs 21 and 22mentioning
confidence: 99%
“…(Received for publication 21 August 1967) With the observations of immune complexes or antigens in the circulation of patients with rheumatoid arthritis (1,2), systemic lupus erythematosus (3,4), and other diseases, much attention has been drawn to their possible significance in the pathogenesis of the lesions in these disorders. Abundant data derived from experimental models have shown that the presence of complexes in the circulation coincides temporally with the development of the lesions, e.g., acute glomerulonephritis and vasculitis (5,6) and chronic glomerulonephritis (7).…”
Section: Platzs 21 and 22mentioning
confidence: 99%
“…In active systemic lupus erythematosus (SLE) it may be low and correlated with the total serum complement (5)(6)(7). Precipitation of the serum cryoglobulins which are frequently present in SLE was first shown by Christian, Hatfield, and Chase to be dependent on the presence of Clq (8). In addition, some patients with active chronic "hypocomplementemic' nephritis have reduced sertuni Clq (9).…”
Section: Introductionmentioning
confidence: 99%
“…For cryoprecipitation to occur, a heat-labile serum factor is required. This factor is present in normal human serum and has been identified as 11 S material (11 S) (6) or the C'lq fraction of the first component of complement (7).…”
Section: Introductionmentioning
confidence: 99%
“…"Mixed" cryoglobulins, in contrast, consist of IgG and IgM in varying proportions and have been described primarily in SLE (6), in a syndrome of purpura, weakness, and arthralgias (8,9), and in other patients with varying clinical pictures (10)(11)(12)(13).…”
Section: Introductionmentioning
confidence: 99%