Systemic lupus erythematosus‐associated neutrophilic dermatosis manifesting as an acneiform eruption and foot pain

Hannah, Claire; Moye, Molly S.; Wanat, Karolyn A.; Liu, V.

doi:10.1111/ced.13900

Cited by 2 publications

(4 citation statements)

References 8 publications

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“…The pattern of pustular lesions in none of these cases was similar to that of our patients. The 24-year-old woman described by Hannah et al 5 who had papules, pustules, and vesicles with hemorrhagic crusts in an annular pattern on the face, the frontal scalp, hard palate, and shins was the only example in which the lesions were almost similar to those of our patient. Nevertheless, in this case, there were dermis-centered scattered eosinophils in the pathology as well as a dense neutrophilic inflammatory infiltrate.…”

Section: Discussionsupporting

confidence: 72%

“…Nevertheless, in this case, there were dermis‐centered scattered eosinophils in the pathology as well as a dense neutrophilic inflammatory infiltrate. 5 Thus, our patient's lesions were located elsewhere and had a distinct pathology.…”

Section: Discussionmentioning

confidence: 77%

“… 15 Moreover, neutrophilic dermatosis might be the first indicator of underlying SLE in up to a third of patients. 14 Likewise, Hannah et al 5 reported a neutrophilic dermatosis linked to SLE which presented as an acneiform eruption in a 24‐year‐old woman. Subcorneal pustular dermatosis has also been reported in a 6‐year‐old boy as a dermatological manifestation antecedent to the diagnosis of SLE.…”

Section: Discussionmentioning

confidence: 99%

“… 1 Interface dermatitis, lichenoid infiltration, basal cell vacuolation, and mucinous deposition are characteristics of the histopathology of LE‐specific lesions. 2 Pustular appearance is one of the least often documented presentations reported in the setting of amicrobial pustulosis of the folds (APF), 3 generalized pustular psoriasis, 4 acneiform eruptions, 5 pustular vasculitis, 6 Wells' syndrome, 7 subcorneal pustular dermatosis, 8 and neutrophilic dermatosis. 9 Here, we describe annular lesions with marginal pustules in a patient whose condition was subsequently identified as SLE.…”

Section: Introductionmentioning

confidence: 99%

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Annular pustular crusted plaques as unusual cutaneous presentation of systemic lupus erythematosus

Gheisari

Baghani

Ganji

et al. 2023

Clinical Case Reports

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Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that affects several organs including the skin. Clinical cutaneous symptoms of SLE come in a broad range, consisting of both non-specific and specific cutaneous lesions. Except for cases of amicrobial pustulosis of the folds, generalized pustular psoriasis, acneiform eruptions, pustular vasculitis, Wells' syndrome, subcorneal pustular dermatosis, and neutrophilic dermatosis, there are no reports of pustular lesions linked to SLE. The unusual cutaneous features of our patient were annular plaques with pustules and crusts on the margins.

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Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Annular pustular crusted plaques as unusual cutaneous presentation of systemic lupus erythematosus

Gheisari

Baghani

Ganji

et al. 2023

Clinical Case Reports

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The Role of Chloroquine and Hydroxychloroquine in Immune Regulation and Diseases

Martínez

Zabaleta

Giulio

et al. 2020

CPD

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: Chloroquine (CQ) and hydroxychloroquine (HCQ) are derivatives of the heterocyclic aromatic compound quinoline. These economical compounds were used as antimalarial agents for many years. Currently, they are used as monotherapy or in conjunction with other therapies for the treatment of autoimmune diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjögren's syndrome (SS) and antiphospholipid antibody syndrome (APS). Based on its effects on the modulation of the autophagy process, various clinical studies suggest that CQ and HCQ could be used in combination with other chemotherapeutics for the treatment of various types of cancer. Furthermore, the antiviral effects showed against Zika, Chikungunya, and HIV are due to the annulation of endosomal/lysosomal acidification. Recently, CQ and HCQ were approved for The U.S. Food and Drug Administration (FDA) for the treatment of infected patients with the coronavirus SARS-CoV-2, causing the disease originated in December 2019, namely COVID-2019. Several mechanisms have been proposed to explain the pharmacological effects of these drugs: 1) disruption of lysosomal and endosomal pH, 2) inhibition of protein secretion/expression, 3) inhibition of antigen presentation, 4) decrease of proinflammatory cytokines, 5) inhibition of autophagy, 6) induction of apoptosis and 7) inhibition of ion channels activation. Thus, evidence has shown that these structures are leader molecules that can be modified or combined with other therapeutic agents. In this review, we will discuss the most recent findings in the mechanisms of action of CQ and HCQ in the immune system, and the use of these antimalarial drugs on diseases.

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Systemic lupus erythematosus‐associated neutrophilic dermatosis manifesting as an acneiform eruption and foot pain

Abstract: Click https://www.wileyhealthlearning.com/ced.aspx for the corresponding questions to this CME article.

Cited by 2 publications

References 8 publications

Annular pustular crusted plaques as unusual cutaneous presentation of systemic lupus erythematosus

Annular pustular crusted plaques as unusual cutaneous presentation of systemic lupus erythematosus

The Role of Chloroquine and Hydroxychloroquine in Immune Regulation and Diseases

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