Systemic Lupus Erythematosus and Crohn's Disease: A Case Report

Rodríguez, Antonia María Fernández; Fernández, Inmaculada Macías; García, Natalia Navas

doi:10.1016/j.reumae.2011.08.001

Cited by 4 publications

(5 citation statements)

References 7 publications

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“…3 The association of SLE and UC is very uncommon and only documented in a limited number of case reports. 26–30 The estimated prevalence of UC in SLE patients is around 0.4%. 1,3,11,25,31…”

Section: Sle and Inflammatory Bowel Diseasementioning

confidence: 99%

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Autoimmune gastrointestinal complications in patients with systemic lupus erythematosus: case series and literature review

Alves¹,

Fasano

Isenberg

2016

Lupus

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The association of systemic lupus erythematosus (SLE) with gastrointestinal autoimmune diseases is rare, but has been described in the literature, mostly as case reports. However, some of these diseases may be very severe, thus a correct and early diagnosis with appropriate management are fundamental. We have analysed our data from the SLE patient cohort at University College Hospital London, established in 1978, identifying those patients with an associated autoimmune gastrointestinal disease. We have also undertaken a review of the literature describing the major autoimmune gastrointestinal pathologies which may be coincident with SLE, focusing on the incidence, clinical and laboratory (particularly antibody) findings, common aetiopathogenesis and complications.

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Section: Sle and Inflammatory Bowel Diseasementioning

confidence: 99%

“…In these cases a colonoscopy with biopsy should be performed. 25,27 Similarly, in patients with IBD and various extra-intestinal manifestations, the coexistence of SLE should be considered. 26,29…”

Section: Sle and Inflammatory Bowel Diseasementioning

confidence: 99%

Autoimmune gastrointestinal complications in patients with systemic lupus erythematosus: case series and literature review

Alves¹,

Fasano

Isenberg

2016

Lupus

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“…We identified 17 patients who developed concomitant SLE and CD; 11 in the English-language literature [1,2,[6][7][8][9][10][11][12][13][14][15] and 6 in the Japanese-language literature [16][17][18][19][20][21]. The patient characteristics are summarized in Table 1.…”

Section: Ibd Subgroup: Cases Of Sle and CDmentioning

confidence: 99%

“…Conversely, only 2% healthy controls and 1.9% CD patients had at least one autoimmune disorder [4,22,23]. The rate of concurrent SLE and UC has been reported to be 0%-0.5% [22], whereas the incidence of UC in SLE patients is approximately 0.4% (2/520) [2,3,12,23].…”

Section: Ibd Subgroup: Cases Of Sle and Ucmentioning

confidence: 99%

“…Gastrointestinal symptoms are common in SLE [2], being present in approximately 50% patients [1]. Occasionally, the gastrointestinal complications of SLE can be difficult to differentiate from those of IBD [6][7][8][9][10][11][12] because these conditions present with similar clinical symptoms; furthermore, there are no clear differentiating criteria. Moreover, some CD patients also meet the criteria for SLE, which further complicates the diagnosis.…”

Section: Differentiation Of Gastrointestinal Complications Of Sle Fromentioning

confidence: 99%

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Coexistence of Systemic Lupus Erythematosus and Inflammatory Bowel Disease

Shizuma¹

2012

Intern Med

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Mucosal healing of Crohn’s disease in a patient with concurrent systemic lupus erythematosus using infliximab

Kagaya

Sakamoto

Yano

et al. 2017

Clin J Gastroenterol

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We describe a patient with Crohn's disease (CD) concurrent with systemic lupus erythematosus (SLE). Continuous prednisolone and cyclosporine treatment resulted in no recurrent symptoms. However, diarrhea, vomiting, and fever occurred for approximately 3 months. A colonoscopy was then performed, which showed a discontinuous cobblestone appearance and longitudinal ulcers extending from the sigmoid colon to the descending colon and distal ileum. A biopsy revealed a noncaseating granulomatous lesion in the colonic mucosa. These findings led to a diagnosis of CD concurrent with SLE. We first attempted treatment with a full elemental diet, mesalazine, and azathioprine, in that order. However, as there was no improvement in inflammation, we started infliximab, a tumor necrosis factor-alpha inhibitor. Transanal double-balloon enteroscopy performed 4 months after starting infliximab showed mucosal healing, suggesting that infliximab was effective. There are few reports of treating patients with CD concurrent with SLE using a tumor necrosis factor-alpha inhibitor. We report our experience with a patient who had mucosal healing with infliximab and review the literature.

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Systemic Lupus Erythematosus and Crohn's Disease: A Case Report

Cited by 4 publications

References 7 publications

Autoimmune gastrointestinal complications in patients with systemic lupus erythematosus: case series and literature review

Autoimmune gastrointestinal complications in patients with systemic lupus erythematosus: case series and literature review

Coexistence of Systemic Lupus Erythematosus and Inflammatory Bowel Disease

Mucosal healing of Crohn’s disease in a patient with concurrent systemic lupus erythematosus using infliximab

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