Coexistence of Systemic Lupus Erythematosus and Inflammatory Bowel Disease

Shizuma, Toru

doi:10.4172/2165-8048.1000140

Cited by 3 publications

(4 citation statements)

References 18 publications

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“…The diagnosis of SLE preceded the diagnosis of CD in 65% of cases. 21 In this case, the patient fitted the typical characteristic profile. She was diagnosed with SLE complicated with renal involvement at the age of 22.…”

Section: Discussionmentioning

confidence: 88%

“…The coexistence of CD and SLE has been perceived as a rare occurrence, especially when SLE is also complicated with renal involvement (lupus nephritis). 21 A prior multivariate logistic regression study by Shor et al showed a strong positive association between SLE and CD (OR = 2.23; 95% CI: 1.46-3.4; p < 0.001), which can be explained by the fact that SLE and CD share some of genetic loci that are exclusive between the two entities, namely TNSF15, CCNY, ICOSLG, and UBE2L3. 22 These genes are essential for several cytokine ligands expression and immune cells activation.…”

Section: Discussionmentioning

confidence: 98%

“…22 The pooled data indicated that IBD associated with the diagnosis of SLE, diagnosis was determined primarily through endoscopic and histopathological findings as in this case, while an additional abdominal CT-scan may be considered to find for the target sign that is highly associated with lupus enteritis. 10,21 Lupus enteritis has two phenotypes, shown by perforated blood vessels (type 1) or nonspecific ulcers, accompanied by granulomatous colitis (type 2). Among both phenotypes, type 2 was known to be barely perceptible from CD.…”

Section: Discussionmentioning

confidence: 99%

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Diagnostic Challenge in Distinguishing Crohn’s Disease from Lupus Enteritis in Systemic Lupus Erythematosus Patient: A Case Report

Layadi

Pribadi

Ariane

et al. 2023

InaJGHE

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Diagnosing Crohn’s disease in systemic lupus erythematosus patients with gastrointestinal symptoms poses a great challenge, due to its rare occurrence and similarity of clinical characteristics between its differential diagnosis. We herein present a rare case of a patient diagnosed with systemic lupus erythematosus, complicated by renal involvement and conspicuous gastrointestinal manifestations. The non-specific gastrointestinal findings in this patient led to challenge in differentiating lupus enteritis from Crohn's disease, as they share many similar aspects in clinical manifestations, endoscopic findings, and histopathological findings. We herein provide the clinical judgement in reaching Crohn's disease in concurrence with systemic lupus erythematosus as the final working diagnosis through scrutinizing and comparing data from similar case studies in the past.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

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Diagnostic Challenge in Distinguishing Crohn’s Disease from Lupus Enteritis in Systemic Lupus Erythematosus Patient: A Case Report

Layadi

Pribadi

Ariane

et al. 2023

InaJGHE

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“… 71 , 72 IBD can be diagnosed at any time during the SLE course; however, according to published data, SLE has usually been diagnosed first. 73 Drug-induced lupus after IBD treatment with sulfasalazine or TNF inhibitors should also be considered.…”

Section: Involvement By Locationmentioning

confidence: 99%

Gastrointestinal Manifestations in Patients with Systemic Lupus Erythematosus

Alharbi¹

2022

OARRR

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Systemic lupus erythematosus (SLE) is an autoimmune disorder of unknown etiology. Women of childbearing age are affected approximately nine times more often than men. Its presentation and course are highly variable, ranging from mild to fulminant systemic disease. Any organ can be affected by SLE. Although less common than in other systems, such as the skin, joints, and kidneys, 40%–60% of SLE patients have gastrointestinal (GI) involvement. SLE can affect any part of the GI tract, from the mouth to the anus. GI manifestations can be caused by SLE, medication-related side effects, or non-SLE causes including infection. This article reviews the most common types of GI involvement associated with SLE.

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