Systemic Lupus Erythematosus After Mesotherapy With Acetyl-L-Carnitine

Colón-Soto, Marilú; Peredo-Wende, Ruben; Vilá, Luis M.

doi:10.1097/01.rhu.0000239831.84504.0b

Cited by 14 publications

(11 citation statements)

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“…Other complications reported are: lichenoid eruption, 33 induction of psoriasis, 34 urticaria, 35,36 cutaneous necrosis, systemic lupus erythematosus, 37 panniculitis, 38 acromia, atrophy and others. 2,[39][40][41][42][43] These complications are attributed to poor techniques or to the effects of the medication itself.…”

Section: Literature Reviewmentioning

confidence: 99%

Mesoterapia: uma revisão bibliográfica

Herreros

Moraes²,

Velho³

2011

An. Bras. Dermatol.

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Intradermotherapy is a medical procedure introduced by Pistor in 1958 that consists in the application of intradermal injections of diluted pharmacological substances that are given directly into the region to be treated. There are reports of the use of intradermotherapy to treat painful diseases, skin diseases and unaesthetic conditions. Medical clinics have been recently offering the treatment of intradermotherapy, using the more popular name for this practice -mesotherapy. There is only scant scientific information about this subject published in periodicals indexed on MedLine. Only a few states rigorously pursue this method. Most indexed publications about this subject deal with the complications of this technique. Unaesthetic dermatoses have been a common complaint in dermatologic clinics, and it has become necessary to have scientific evidence to give to patients. Therefore, well-researched scientific studies about this technique are necessary to offer data to medical professionals that will clearly explain to patients both the benefits and the risks of these procedures. A bibliographical review was conducted and we verified the need for new studies with adequate methods to confirm the benefits of intradermotherapy as used in dermatologic treatment. Keywords: Injections, intradermal; Review; Skin; Therapeutics Resumo: A intradermoterapia é um procedimento médico introduzido por Pistor, em 1958, e consiste na aplicação, diretamente na região a ser tratada, de injeções intradérmicas de substâncias farmacológicas muito diluídas. Esse método é capaz de estimular o tecido que recebe os medicamentos tanto pela ação da punctura quanto pela ação dos fármacos, e apregoa-se que sua vantagem é evitar o uso de medicação sistê-mica. Há relatos da utilização da intradermoterapia para tratamento de doenças dolorosas, dermatoses e condições consideradas inestéticas. Atualmente, clínicas médicas oferecem esse tratamento, utilizando, porém, o nome mais popular para essa prática, mesoterapia. Há escassa informação científica sobre o tema publicada em periódicos indexados no MedLine e poucos estudos com metodologia mais rigorosa sobre a eficácia e o mecanismo de ação da via intradérmica. A maioria das publicações indexadas sobre esse tema versa sobre as complicações dessa técnica. As dermatoses inestéticas têm se tornado queixas frequentes nos consultórios dermatológicos, sendo necessário um embasamento científico para lidar com tais pacientes, os quais, muitas vezes, estão em busca das novidades mostradas através da mídia. Assim, há necessidade de estudos cientificamente bem conduzidos sobre essa técnica. Estes estudos deverão oferecer aos médicos elementos para esclarecer os pacientes sobre quais benefícios esperar e quais os riscos de tal abordagem. Desse modo, realizou-se uma revisão bibliográfica sobre o assunto e constatou-se a necessidade de novos estudos com metodologia adequada para a confirmação dos benefícios da intradermoterapia como ferramenta útil no tratamento dermatológico.

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Section: Literature Reviewmentioning

confidence: 99%

Mesoterapia: uma revisão bibliográfica

Herreros

Moraes²,

Velho³

2011

An. Bras. Dermatol.

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“…As such, is a reported induction of severe systemic lupus erythematosus in a 31‐year‐old patient after mesotherapy with acetyl‐ l ‐carnitine, an agent with known immunomodulating effects, which is frequently used for fat reduction purposes . In this dramatic case described by Colon‐Soto et al, an aggressive immunosuppressive regimen with a methylprednisolone pulse therapy, oral prednisone daily, as well as a pulse therapy with intravenous cyclophosphamide, was necessary for disease control …”

Section: Resultsmentioning

confidence: 95%

“…Although this case cannot be characterized as a koebnerization, but rather as a positive pathergy test––which is the hyperreactivity reaction seen in Behcet's disease as a response to cutaneous trauma––it is still an indication that mesotherapy can trigger the eruption of various dermatologic and systemic conditions with several pathogenetic mechanisms, that are not always fully understood . As such, is a reported induction of severe systemic lupus erythematosus in a 31‐year‐old patient after mesotherapy with acetyl‐ l ‐carnitine, an agent with known immunomodulating effects, which is frequently used for fat reduction purposes . In this dramatic case described by Colon‐Soto et al, an aggressive immunosuppressive regimen with a methylprednisolone pulse therapy, oral prednisone daily, as well as a pulse therapy with intravenous cyclophosphamide, was necessary for disease control …”

Section: Resultsmentioning

confidence: 98%

“…44 In this dramatic case described by Colon-Soto et al, an aggressive immunosuppressive regimen with a methylprednisolone pulse therapy, oral prednisone daily, as well as a pulse therapy with intravenous cyclophosphamide, was necessary for disease control. 44 Less frequently seen are mechanical complications due to the migration of the injected substances during mesotherapy. 45,46 Calonge et al describe the case of a 43-year-old woman who developed massive subcutaneous edema on the right flank and anterior abdominal wall up to the submammary fold, following subcutaneous injections of carbon dioxide on both thighs in the previous days.…”

Section: Granulomatous Foreign Body Reactions Have Been Reported Tomentioning

confidence: 93%

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Mesotherapy: Safety profile and management of complications

Plachouri

Georgiou

2019

J of Cosmetic Dermatology

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Background Mesotherapy is a procedure that involves the injection of active substances into the dermis and subcutaneous tissue in order to treat several local medical and cosmetic conditions. Despite being considered as a relatively safe method, a series of adverse reactions can occur due to its wide application and lack of standardization processes. Objectives The aim of this paper is to summarize all the mesotherapy‐related complications published so far, and to provide an insight into their management. Patient/Methods Articles derived from the databases, PubMed, EMBASE, and SCOPUS, and published between 1992 and 2018, were analyzed for this review. The study was conducted according to the PRISMA guidelines. Results In this literature, there is a number of case series and isolated case reports describing various side effects of different severities. The therapeutic management of these complications is—in most cases—individualized. Conclusions Larger systematic studies are needed in order to adequately evaluate the safety profile of mesotherapy, and in order to determine standardized therapy parameters, so as to minimize the risk of potential adverse reactions.

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“…The exact cause of the nephropathy was not discovered, and the herbs used in the mesotherapy were not approved to be safely administered by an injectable route . There is also a report of systemic lupus erythematosus after mesotherapy with acetyl‐L‐carnitine .…”

Section: Safetymentioning

confidence: 99%

Mesotherapy for local fat reduction

Jayasinghe

Guillot

Bissoon³

et al. 2013

Obesity Reviews

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Mesotherapy, which is the injection of substances locally into mesodermally derived subcutaneous tissue, developed from empirical observations of a French physician in the 1950s. Although popular in Europe for many medical purposes, it is used for local cosmetic fat reduction in the United States. This paper reviews manuscripts indexed in PubMed/MEDLINE under 'mesotherapy', which pertains to local fat reduction. The history of lipolytic mesotherapy, the physiology of body fat distribution, the mechanism of action of different lipolytic stimulators and their increased efficacy in combination are reviewed. Mesotherapy falls into two categories. Lipolytic mesotherapy using lipolytic stimulators requires more frequent treatments as the fat cells are not destroyed and can refill over time. Ablative mesotherapy destroys fat cells with a detergent, causes inflammation and scarring from the fat necrosis, but requires fewer treatments. The historic and empiric mixing of sodium channel blocking local anaesthetics in mesotherapy solutions inhibits the intended lipolysis. Major mesotherapy safety concerns include injection site infections from poor sterile technique. Cosmetic mesotherapy directs the area from which fat is lost to improve self-image. Studies were of relatively small number, many with limited sample sizes. Future research should be directed towards achieving a Food and Drug Administration indication rather than continuing expansion of off-label use.

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Systemic Lupus Erythematosus After Mesotherapy With Acetyl-L-Carnitine

Cited by 14 publications

References 10 publications

Mesoterapia: uma revisão bibliográfica

Mesoterapia: uma revisão bibliográfica

Mesotherapy: Safety profile and management of complications

Mesotherapy for local fat reduction

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