Systemic juvenile rheumatoid arthritis complicated by two different renal lesions

Abstract

Systemic-onset juvenile rheumatoid arthritis (JRA) is a complex disease which affects many organ systems. Associated renal lesions are unusual, with the possible exception of amyloidosis. We describe a girl with systemic-onset JRA who developed first membranous nephropathy and then, 3.5 years later, a severe crescentic glomerulonephritis. The membranous lesion followed therapy with intravenous immune globulin, and the possibility that this intervention caused the renal disease must be considered. It appears that both of these lesions should be added to the list of possible complications of systemiconset JRA.

Pulmonary fibrosis and other clinical manifestations of small vessel vasculitis in a family with seropositive juvenile rheumatoid arthritis

“…24±26 Severe ANCA-negative crescentic glomerulonephritis in association with systemic onset JRA has also been described. 27 Similar to the ®ndings in previous reports, 22``r heumatoid vasculitis'' could be considered to be the underlying pathology in the reported family. We assume that the vasculitis in the lungs, kidney, and skin in the family described here displays many of the systemic manifestations of JRA.…”

Steroid-responsive nephrotic syndrome in a child with juvenile idiopathic arthritis

“…1 a A renal biopsy showing a light microscopy (LM) picture of mild mesangial hypercellularity with a slightly increased mesangial matrix. b Using immunofluorescence (IF) we detected the presence of mesangial deposits of IgG (+++), granular deposits of C3 (++ to +++), irregular deposits of C1q (++) and irregular granular IgM (++) (arrows) direct consequence of the underlying rheumatic disease [7][8][9][10][11]. NS in JIA is extremely rare and is frequently steroid resistant.…”

“…Renal manifestations associated with JIA are rarely observed, and they include membranous nephropathy [8], mesangial GN [9,10], focal segmental glomerulosclerosis [9] and crescentic GN [11]. Proteinuria and nephritic syndrome (NS) are extremely rare in JIA.…”

Гломерулярные Поражения Почек У Детей С Ювенильным Ревматоидным Артритом (Обзор Литературы)

“…Мембранозная нефропатия описана у трех детей школьного возраста с полиартикулярной и системной формами ЮРА [31][32][33]. Возникновение МН отмечено в течение одного года от дебюта ЮРА и проявилось бессимптомной протеинурией различной степени.…”

“…Возникновение МН отмечено в течение одного года от дебюта ЮРА и проявилось бессимптомной протеинурией различной степени. Кроме этого, у двух пациентов наблюдалось повышение уровня холестерина крови [31,33]. Функциональное состояние почек не было нарушено.…”