Systemic Infusional Chemotherapy for Liver Metastasis: An Improved Schedule for 5-Fluorouracil

Lokich, J. J.

doi:10.1007/978-3-642-82635-1_17

Cited by 3 publications

(1 citation statement)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The prognosis of patients with liver metastasis of colon cancer is still poor. Many modalities of treatment using 5-FU against liver metastases of colon cancer have been tried for these patients and good response rates have been reported, including systemic infusion therapy [20], hepatic arterial infusion therapy [21,22], portal vein infusion therapy [23,24j, intraperitoneal infusion 1251, combination therapy of 5-FU and cisplatin [3], and biochemical modulation of 5-FU by methotrexate [26], leucovorin [26,27], levamisole [28], or interferon [29j. However, at the present time, no major benefit in survival has been disclosed in any of these treatments [ 3 ] .…”

Section: Discussionmentioning

confidence: 99%

Experimental cancer chemotherapy using A liver metastatic model of human colon cancer transplanted into the spleen of severe combined immunodeficient mice

Kuo

Kubota

Nishibori

et al. 1993

Journal of Surgical Oncology

View full text Add to dashboard Cite

We have developed a liver metastatic model of human colon cancer using severe combined immunodeficient (SCID) mice. Liver metastases were observed in all the SCID mice on day 28 after intrasplenic injection with 5 x 10(6) dissociated tumor cells of COL-2-JCK, a human colon cancer strain serially transplanted in nude mice. When this model was applied for chemotherapeutic experiments, 5-fluorouracil (5-FU) demonstrated significant antitumor effects in preventing liver metastases, whereas the efficacy of 5-FU was limited in the currently used sc-ip chemosensitivity assay in nude mice. When the human LDH-5 isozyme was evaluated in the homogenized metastatic liver tissue of SCID mice, a good correlation was obtained between the liver tumor weights and LDH-5 isozyme, suggesting that it could be a promising quantitative indicator for metastases. This model would be useful for further studies on the treatment of liver metastases of colon cancer.

show abstract

Section: Discussionmentioning

confidence: 99%

Experimental cancer chemotherapy using A liver metastatic model of human colon cancer transplanted into the spleen of severe combined immunodeficient mice

Kuo

Kubota

Nishibori

et al. 1993

Journal of Surgical Oncology

View full text Add to dashboard Cite

show abstract

Liver Infusion Chemotherapy

Schlag¹,

Herfarth²

1989

Surgical Oncology

View full text Add to dashboard Cite

Radioimmunoguided surgery using the monoclonal antibody B72.3 in colorectal tumors

Sickle‐Santanello

Mojzisik

et al. 1987

Diseases of the Colon &Amp; Rectum

View full text Add to dashboard Cite

The authors have developed a hand-held gamma-detecting probe (GDP) for intraoperative use that improves the sensitivity of external radioimmunodetection. Radiolabeled monoclonal antibody (MAb) B72.3 was injected in six patients with primary colorectal cancer and 31 patients with recurrent colorectal cancer an average of 16 days preoperatively. The GDP localized the MAb B72.3 in 83 percent of sites. The technique, known as a radioimmunoguided surgery (RIGS) system did not alter the surgical procedure in patients with primary colorectal cancer but did alter the approach in 26 percent (8/31) of patients with recurrent colorectal cancer. Two patients avoided unnecessary liver resections and two underwent extraabdominal approaches to document their disease. The RIGS system may influence the short-term morbidity and mortality of surgery for colorectal cancer. Larger series and longer follow-up are needed to determine whether the RIGS system confers a survival advantage to the patient with colorectal cancer.

show abstract

Systemic Infusional Chemotherapy for Liver Metastasis: An Improved Schedule for 5-Fluorouracil

Cited by 3 publications

References 9 publications

Experimental cancer chemotherapy using A liver metastatic model of human colon cancer transplanted into the spleen of severe combined immunodeficient mice

Experimental cancer chemotherapy using A liver metastatic model of human colon cancer transplanted into the spleen of severe combined immunodeficient mice

Liver Infusion Chemotherapy

Radioimmunoguided surgery using the monoclonal antibody B72.3 in colorectal tumors

Contact Info

Product

Resources

About