Radioimmunoguided surgery using the monoclonal antibody B72.3 in colorectal tumors

Abstract

The authors have developed a hand-held gamma-detecting probe (GDP) for intraoperative use that improves the sensitivity of external radioimmunodetection. Radiolabeled monoclonal antibody (MAb) B72.3 was injected in six patients with primary colorectal cancer and 31 patients with recurrent colorectal cancer an average of 16 days preoperatively. The GDP localized the MAb B72.3 in 83 percent of sites. The technique, known as a radioimmunoguided surgery (RIGS) system did not alter the surgical procedure in patients with primary colorectal cancer but did alter the approach in 26 percent (8/31) of patients with recurrent colorectal cancer. Two patients avoided unnecessary liver resections and two underwent extraabdominal approaches to document their disease. The RIGS system may influence the short-term morbidity and mortality of surgery for colorectal cancer. Larger series and longer follow-up are needed to determine whether the RIGS system confers a survival advantage to the patient with colorectal cancer.

Feasibility study of radioimmunoguided surgery of colorectal carcinomas using indium-111 CEA-specific monoclonal antibody

“…The purpose of this study was to evaluate the efficiency of RIGS using a CEA-specific antibody labelled with indium 111 instead of the iodine 125 used in previous studies (Martin et al 1986Nieroda et al 1989;Oredipe et al 1988;Sardi et al 1989;Sickle-Santanello et al 1987). As the long physical half-life of iodine 125 limits its routine clinical use, indium 111 was chosen.…”

“…1986(Martin etal. , 1988O'Dwyer et al 1986;Sickle-Santanello et al 1987;. Various antibodies have been labelled with iodine 125 which has a low-energy radiation easily absorbed by a thin layer of tissue.…”

Localization of human sarcoma with radiolabeled monoclonal antibody — a follow-up report

“…However, low-energy emission from 125I is more suitable for external-probe detection than 1311 and 1251 has been applied in intraoperative detection of colorectal cancer [13,22]. Though surprisingly good imaging results have been obtained to date, other more suitable radiolabels such as 111in are being evaluated.…”

Radioimmunoguided surgery and intraoperative lung cancer staging

“…into the patient. During surgery, a survey is made at the primary and secondary foci of tumor by means of a hand-held gamma-detecting probe (Neoprobe 1000, Neoprobe Co., Dublin, OH) [1][2][3][4]. This method has not been adopted by some authors in the lung field because of interference from the high radioactivity background caused by the heart and large vessels in the thorax [5,6].…”